公开(公告)号：US06223086B1

公开(公告)日：2001-04-24

申请号：US09504768

申请日：2000-02-09

Applicant: James R. Carl ,  G. Dickey Arndt ,  Patrick W. Fink ,  N. Reginald Beer ,  Phillip D. Henry ,  Antonio Pacifico ,  George W. Raffoul

Inventor： James R. Carl ,  G. Dickey Arndt ,  Patrick W. Fink ,  N. Reginald Beer ,  Phillip D. Henry ,  Antonio Pacifico ,  George W. Raffoul

IPC: A61F200

CPC classification number: A61B18/18 ,  A61B18/1206 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00732 ,  A61B2018/00791 ,  A61B2018/1861 ,  A61N1/06

Abstract: Method and apparatus are provided to treat atherosclerosis wherein the artery is partially closed by dilating the artery while preserving the vital and sensitive endothelial layer thereof. Microwave energy having a frequency from 3 GHz to 300 GHz is propagated into the arterial wall to produce a desired temperature profile therein at tissue depths sufficient for thermally necrosing connective tissue and softening fatty and waxy plaque while limiting heating of surrounding tissues including the endothelial layer and/or other healthy tissue, organs, and blood. The heating period for raising the temperature a potentially desired amount, about 20° C. within the atherosclerotic lesion may be less than about one second. In one embodiment of the invention, a radically beveled waveguide antenna is used to deliver microwave energy at frequencies from 25 GHz or 30 GHz to about 300 GHz and is focused towards a particular radial sector of the artery. Because the atherosclerotic lesions are often asymmetrically disposed directable or focussed heating preserves healthy sectors of the artery and applies energy to the asymmetrically positioned lesion faster than a non-directed beam. A computer simulation predicts isothermic temperature profiles for the given conditions and may be used in selecting power, pulse duration, beam width, and frequency of operation to maximize energy deposition and control heat rise within the atherosclerotic lesion without harming healthy tissues or the sensitive endothelium cells.

Abstract translation: 提供了治疗动脉粥样硬化的方法和装置，其中动脉通过扩张动脉而部分闭合，同时保留其重要且敏感的内皮层。 具有频率从3GHz到300GHz的微波能量传播到动脉壁中以在组织深度处产生期望的温度曲线，其组织深度足以热破坏结缔组织和软化脂肪和蜡状斑块，同时限制包括内皮层的周围组织的加热和 /或其他健康的组织，器官和血液。 在动脉粥样硬化病变期间将温度提高至约20℃的潜在期望量的加热期可以小于约1秒。 在本发明的一个实施例中，使用自旋斜面波导天线以25GHz或30GHz至约300GHz的频率传送微波能量，并且朝着动脉的特定径向扇区聚焦。 由于动脉粥样硬化病变通常是不对称地布置的可直接或聚焦的加热保留了动脉的健康部分，并且比非定向的束更快地将能量施加到不对称定位的病变处。 计算机模拟预测给定条件下的等温温度曲线，并且可用于选择功率，脉冲持续时间，波束宽度和操作频率以最大限度地增加能量沉积并控制动脉粥样硬化病变中的热上升而不伤害健康组织或敏感的内皮细胞 。

公开(公告)号：US5741979A

公开(公告)日：1998-04-21

申请号：US556241

申请日：1995-11-09

Applicant: G. Dickey Arndt ,  James R. Carl

Inventor： G. Dickey Arndt ,  James R. Carl

IPC: G01F1/708 ,  G01F1/74

CPC classification number: G01F1/74 ,  G01F1/708

Abstract: Method and apparatus are provided for determining the velocity of individual food particles within a liquid/solid food mixture that is cooked by an aseptic cooking method whereby the food mixture is heated as it flows through a flowline. At least one upstream and at least one downstream microwave transducer are provided to determine the minimum possible travel time of the fastest food particle through the flowline. In one embodiment, the upstream detector is not required. In another embodiment, a plurality of small dipole antenna markers are secured to a plurality of food particles to provide a plurality of signals as the markers pass the upstream and downstream transducers. The dipole antenna markers may also include a non-linear element to reradiate a harmonic frequency of a transmitter frequency. Upstream and downstream transducers include dipole antennas that are matched to the impedance of the food slurry and a signal transmission cable by various impedance matching means including unbalanced feed to the antennas.

Abstract translation: 提供了用于确定通过无菌烹饪方法烹饪的液体/固体食物混合物中的单个食物颗粒的速度的方法和装置，由此当食物混合物流过流线时被加热。 提供至少一个上游和至少一个下游微波换能器以确定最快的食物颗粒通过流线的最小可行程时间。 在一个实施例中，不需要上游检测器。 在另一个实施例中，随着标记通过上游和下游换能器，多个小偶极子天线标记被固定到多个食物颗粒以提供多个信号。 偶极天线标记还可以包括用于重新辐射发射机频率的谐波频率的非线性元件。 上游和下游换能器包括与食物浆料的阻抗相匹配的偶极子天线，以及通过包括对天线的不平衡馈电的各种阻抗匹配装置的信号传输电缆。