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公开(公告)号：US20050049274A1
公开(公告)日：2005-03-03
申请号：US10894940
申请日：2004-07-20
申请人： Mark Wall , Mark Player , Raymond Patch , Sanath Meegalla , Jian Liu , Carl Illig , Wing Cheung , Jinsheng Chen , Davoud Asgari
发明人： Mark Wall , Mark Player , Raymond Patch , Sanath Meegalla , Jian Liu , Carl Illig , Wing Cheung , Jinsheng Chen , Davoud Asgari
IPC分类号： A61P35/00 , C07D215/22 , C07D215/227 , C07D401/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/02 , A61K31/47 , C07D215/36
CPC分类号： C07D215/227 , C07D401/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , Y02P20/582
摘要： The invention is directed to compounds of Formulae I and II: wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.
摘要翻译： 本发明涉及式I和II的化合物：其中R 1，R 2，R 3，R 5，R 6，Y 1，Y 2， 3>，Y 4和X在说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-fms激酶的溶剂合物，水合物，互变异构体或其药学上可接受的盐。
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公开(公告)号：US08198062B2
公开(公告)日：2012-06-12
申请号：US12202119
申请日：2008-08-29
申请人： Timothy Hitchman , Christopher L. G. Dayton , Katie A. Kline , Jonathan Lyon , Mark Wall , Nelson R. Barton
发明人： Timothy Hitchman , Christopher L. G. Dayton , Katie A. Kline , Jonathan Lyon , Mark Wall , Nelson R. Barton
CPC分类号： C12N9/20 , A23L29/06 , A23V2002/00 , A61K8/64 , A61K8/66 , A61K2800/10 , A61Q19/00 , C11D3/386 , C11D3/38681 , C12N9/16 , C12Y301/01021
摘要： Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils.
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