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公开(公告)号:US06884574B2
公开(公告)日:2005-04-26
申请号:US09966755
申请日:2001-09-28
申请人: David P. Andrew , Brian A. Zabel , Paul D. Ponath
发明人: David P. Andrew , Brian A. Zabel , Paul D. Ponath
IPC分类号: G01N33/50 , A61K39/395 , A61K45/00 , A61P3/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , C07K16/24 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/02 , G01N33/15 , G01N33/566 , G01N33/58 , C12Q1/00
CPC分类号: C07K16/2866 , C07K16/24 , C07K2317/76 , Y10S435/81 , Y10S435/975
摘要: The invention relates to an antibody or antigen-binding fragment thereof which binds to the CC chemokine receptor GPR-9-6 and blocks the binding of a ligand (e.g., TECK) to the receptor. The invention also relates to a method of identifying agents (molecules, compounds) which can bind to GPR-9-6 and inhibit the binding of a ligand (e.g., TECK) and/or modulate a function of GPR-9-6. The invention further relates to a method of modulating a function of GPR-9-6, and to the use of the antibodies, antigen-binding fragments and agents identified by the method of the invention in research, therapeutic, prophylactic and diagnostic methods.
摘要翻译: 本发明涉及与CC趋化因子受体GPR-9-6结合并阻断配体(例如TECK)与受体结合的抗体或其抗原结合片段。 本发明还涉及鉴定可以结合GPR-9-6并抑制配体(例如TECK)结合和/或调节GPR-9-6的功能的试剂(分子,化合物)的方法。 本发明还涉及调节GPR-9-6的功能的方法,以及通过本发明的方法鉴定的抗体,抗原结合片段和试剂在研究,治疗,预防和诊断方法中的用途。