公开(公告)号：US09458076B2

公开(公告)日：2016-10-04

申请号：US14652339

申请日：2013-12-18

Applicant: DSM IP ASSETS B.V.

Inventor： Werner Bonrath ,  Thomas Netscher ,  Jonathan Alan Medlock ,  René Tobias Stemmler ,  Gerardus Karel Maria Verzijl ,  Andreas Hendrikus Maria De Vries

IPC: C07C45/62 ,  C07C43/303 ,  C07D311/58 ,  C07C50/14 ,  C07C45/82

CPC classification number: C07C45/62 ,  C07B2200/07 ,  C07B2200/09 ,  C07C43/303 ,  C07C45/82 ,  C07C50/14 ,  C07D311/58 ,  C07C49/203 ,  C07C49/04 ,  C07C47/02

Abstract: The present invention relates to a process of manufacturing compound having stereogenic centers from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centers. The process involves two asymmetric hydrogenation steps. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.

Abstract translation: 本发明涉及由具有前手性双键的不饱和化合物的E / Z异构体的混合物制造具有立体中心化合物的方法。 氢化产物在立体中心处具有特定的所需构型。 该方法涉及两个不对称氢化步骤。 该方法非常有利，因为它以有效的方式从起始产物的立体异构体的混合物形成所需的手性产物。

公开(公告)号：US20140206905A1

公开(公告)日：2014-07-24

申请号：US14241288

申请日：2012-09-21

Applicant: DSM IP ASSETS B.V.

Inventor： Gerhard Schiefer ,  Thomas Netscher ,  Alexander Lucia Leonardus Duchateau

IPC: C07C46/10 ,  C07C37/00

CPC classification number: C07C46/10 ,  C07B2200/07 ,  C07C37/002 ,  C07C37/14 ,  C07C45/71 ,  C07C46/00 ,  C07C50/06

Abstract: The present invention relates to a process of preparing tocotrienol quinones. It has been found that this process allows the formation of the R-isomer in a high yield in a very efficient and economically interesting way. Said process is particularly useful when implemented in an industrial process. Furthermore, it has been found that this process allows using isomer mixtures as they result from traditional industrial synthesis.

Abstract translation: 本发明涉及一种制备生育三烯酚醌的方法。 已经发现，该方法以非常有效和经济上有趣的方式允许以高产率形成R-异构体。 当在工业过程中实施时，所述方法特别有用。 此外，已经发现，该方法允许使用由传统工业合成得到的异构体混合物。