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公开(公告)号：US20170071736A1
公开(公告)日：2017-03-16
申请号：US15260192
申请日：2016-09-08
发明人： Yidong M. Zhu , Erik Bulman , Baigui Bian , Sam Sok , Pu Zhou
CPC分类号： A61F2/2433 , A61F2/2418 , A61M25/1002 , A61M25/1011 , A61M2025/1086 , A61M2025/1095 , A61M2025/1097
摘要： Disclosed herein are designs for improved inflatable structures for use during minimally invasive cardiovascular procedures. These inflatable structures facilitate the perfusion of blood through an anatomical structure, such as a heart valve, during the cardiovascular procedure. The inflatable structures are formed of a plurality of balloons arranged radially around a central location. The plurality of balloons form a lumen through which blood flows. Each balloon of the plurality is shaped or configured to stabilize the adjacent balloons, limiting their movement relative to each other. For example, some embodiments can feature balloons with a keystone shape that limits movement of the balloons inward toward the lumen. Some implementations can also include a support coil running through the lumen. The support coil holds enables the lumen to be open to perfusion even in the early stages of balloon inflation.
摘要翻译： 本文公开了用于在微创心血管程序中使用的改进的可充气结构的设计。 在心血管手术过程中，这些充气结构有助于通过解剖结构（例如心脏瓣膜）灌注血液。 可膨胀结构由围绕中心位置径向排列的多个气球形成。 多个气球形成血液流过的内腔。 多个的每个气囊被成形或构造成稳定相邻气球，限制它们相对于彼此的运动。 例如，一些实施例可以具有限制气囊朝着内腔向内移动的梯形形状的气球。 一些实施方案还可以包括穿过管腔的支撑线圈。 即使在球囊充气的早期阶段，支撑线圈支架也能使内腔开放以灌注。
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公开(公告)号：US20240358976A1
公开(公告)日：2024-10-31
申请号：US18766277
申请日：2024-07-08
发明人： Pu Zhou , Erik Bulman , Baigui Bian
CPC分类号： A61M25/0662 , A61F2/2436 , A61M25/0023 , A61F2/2433 , A61F2/958 , A61M2025/0024 , A61M25/005
摘要： An expandable delivery sheath includes an elastic outer tubular layer and an inner tubular layer. The inner tubular layer includes a thick wall portion integrally connected to a thin wall portion. The thin wall portion can include longitudinal reinforcing members/rods that facilitate unfolding during the passage of the implant, thus decreasing the push force and increasing the consistency of the push force. The inner tubular layer can have a non-expanded or folded condition wherein the thin wall portion folds onto an outer surface of the thick wall portion under urging of the elastic outer tubular layer. When an implant passes therethrough, the outer tubular layer stretches and the inner tubular layer unfolds into an expanded lumen diameter. Once the implant passes, the outer tubular layer again urges the inner tubular layer into the non-expanded condition with the sheath reassuming its smaller profile.
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公开(公告)号：US11547561B2
公开(公告)日：2023-01-10
申请号：US16996776
申请日：2020-08-18
发明人： Yidong M. Zhu , Pu Zhou , Erik Bulman , Baigui Bian
摘要： The methods and devices disclosed herein promote temporal control of balloon inflation patterns. The devices include a covering for a portion of the balloon that compresses the balloon portion during the inflation process. This enables the distal portion of a balloon to be inflated prior to the proximal portion of a balloon, creating a tapered shape at lower inflation pressures. This is especially useful during transvascular implantation procedures, as it prevents dislodgement of an implant mounted on the balloon. As inflation continues, pressure exerted on the balloon by the covering is overcome such that the proximal region of the balloon inflates, forming a shape with generally straighter sides than the tapered shape, thereby expanding the cardiovascular device.
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公开(公告)号：US11420026B2
公开(公告)日：2022-08-23
申请号：US16550922
申请日：2019-08-26
发明人： Pu Zhou , Erik Bulman , Timothy A. Geiser , Michael G. Valdez , Yidong M. Zhu , Baigui Bian , Sonny Tran , Richard D. White , Thanh Huy Le , Tung T. Le , Alpana Kiran Gowdar , Yong Gao , David Delon Williams
摘要： A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.
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公开(公告)号：US10561496B2
公开(公告)日：2020-02-18
申请号：US15260192
申请日：2016-09-08
发明人： Yidong M. Zhu , Erik Bulman , Baigui Bian , Sam Sok , Pu Zhou
摘要： Disclosed herein are designs for improved inflatable structures for use during minimally invasive cardiovascular procedures. These inflatable structures facilitate the perfusion of blood through an anatomical structure, such as a heart valve, during the cardiovascular procedure. The inflatable structures are formed of a plurality of balloons arranged radially around a central location. The plurality of balloons form a lumen through which blood flows. Each balloon of the plurality is shaped or configured to stabilize the adjacent balloons, limiting their movement relative to each other. For example, some embodiments can feature balloons with a keystone shape that limits movement of the balloons inward toward the lumen. Some implementations can also include a support coil running through the lumen. The support coil holds enables the lumen to be open to perfusion even in the early stages of balloon inflation.
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公开(公告)号：US10391279B2
公开(公告)日：2019-08-27
申请号：US16149636
申请日：2018-10-02
发明人： Pu Zhou , Erik Bulman , Timothy A. Geiser , Michael G. Valdez , Yidong M. Zhu , Baigui Bian , Sonny Tran , Richard D. White , Thanh Huy Le , Tung T. Le , Alpana K. Gowdar , Yong Gao , David D. Williams
摘要： A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.
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公开(公告)号：US10327896B2
公开(公告)日：2019-06-25
申请号：US14880111
申请日：2015-10-09
发明人： Pu Zhou , Yong Gao , Erik Bulman , Baigui Bian , Yidong M. Zhu , David D. Williams
摘要： An expandable introducer sheath for passage of implant delivery catheters, such as catheters for delivery of prosthetic heart valves. The expandable sheath balances the amounts, shapes and positions of various stiff and elastic structures in the sheath to selectively program the expandability and buckling stiffness of the sheath. The expandable sheath can include, for example, an expandable tubular layer that includes alternating stiff and elastic wall portions of a single radial thickness. The combination of stiff and elastic wall portions allow for torque and push strength to advance the expandable sheath while at the same time accommodating temporary expansion. The expandable sheath can also be reinforced with a tubular layer of braided fibers or a stent structure for additional strength. Other embodiments include selective use of slots or gaps at the distal end of a stiff wall portion to enhance expandability and distribute strain.
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公开(公告)号：US20190030298A1
公开(公告)日：2019-01-31
申请号：US16149683
申请日：2018-10-02
发明人： Pu Zhou , Erik Bulman , Timothy A. Geiser , Michael G. Valdez , Yidong M. Zhu , Baigui Bian , Sonny Tran , Richard D. White , Thanh Huy Le , Tung T. Le , Alpana K. Gowdar , Yong Gao , David D. Williams
摘要： A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.
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公开(公告)号：US20170056170A1
公开(公告)日：2017-03-02
申请号：US15248517
申请日：2016-08-26
发明人： Yidong M. Zhu , Pu Zhou , Erik Bulman , Baigui Bian
摘要： The methods and devices disclosed herein promote temporal control of balloon inflation patterns. The devices include a covering for a portion of the balloon that compresses the balloon portion during the inflation process. This enables the distal portion of a balloon to be inflated prior to the proximal portion of a balloon, creating a tapered shape at lower inflation pressures. This is especially useful during transvascular implantation procedures, as it prevents dislodgement of an implant mounted on the balloon. As inflation continues, pressure exerted on the balloon by the covering is overcome such that the proximal region of the balloon inflates, forming a shape with generally straighter sides than the tapered shape, thereby expanding the cardiovascular device.
摘要翻译： 本文公开的方法和装置促进球囊充气模式的时间控制。 这些装置包括用于在膨胀过程期间压缩气囊部分的气囊的一部分的覆盖物。 这使得球囊的远端部分在球囊的近端部分之前被充气，在较低的充气压力下产生锥形形状。 这在经血管植入手术期间特别有用，因为它可防止安装在气囊上的植入物的移位。 当膨胀持续时，通过覆盖物施加在气囊上的压力被克服，使得球囊的近侧区域膨胀，形成具有比锥形形状大致更直的侧面的形状，从而使心血管装置膨胀。
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公开(公告)号：US12053597B2
公开(公告)日：2024-08-06
申请号：US18207076
申请日：2023-06-07
发明人： Pu Zhou , Erik Bulman , Baigui Bian
CPC分类号： A61M25/0662 , A61F2/2436 , A61M25/0023 , A61F2/2433 , A61F2/958 , A61M2025/0024 , A61M25/005
摘要： An expandable delivery sheath includes an elastic outer tubular layer and an inner tubular layer. The inner tubular layer include a thick wall portion integrally connected to a thin wall portion. The thin wall portion can include longitudinal reinforcing members/rods that facilitate unfolding during the passage of the implant, thus decreasing the push force and increasing the consistency of the push force. The inner tubular layer can have a non-expanded or folded condition wherein the thin wall portion folds onto an outer surface of the thick wall portion under urging of the elastic outer tubular layer. When an implant passes therethrough, the outer tubular layer stretches and the inner tubular layer unfolds into an expanded lumen diameter. Once the implant passes, the outer tubular layer again urges the inner tubular layer into the non-expanded condition with the sheath reassuming its smaller profile.
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