公开(公告)号：US20160059160A1

公开(公告)日：2016-03-03

申请号：US14839852

申请日：2015-08-28

Applicant: EMD Millipore Corporation

Inventor： Jonathan Steen ,  Mikhail Kozlov ,  Herbert Lutz ,  Joseph Parrella ,  Elizabeth M. Goodrich ,  Bala Raghunath

IPC: B01D29/90 ,  B01D29/52 ,  B01D29/60

CPC classification number: B01D29/908 ,  B01D29/52 ,  B01D29/603 ,  B01D61/142 ,  B01D61/145 ,  B01D61/147 ,  B01D63/04 ,  B01D63/12 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/21 ,  B01D2313/44 ,  B01D2315/10

Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

Abstract translation: 公开了过滤液体进料的方法。 在一个版本中，该方法包括使液体进料通过单通道切向流过滤（SPTFF）系统，并且在分离的容器中从系统中回收渗余物和渗透物，而不通过SPTFF系统再循环。 在另一个版本中，过滤液体进料的方法包括使液体进料通过切向流过滤（TFF）系统，在分离的容器中从体系中回收渗透物和一部分滞留物，而不通过TFF系统再循环 剩余的残留物通过TFF系统至少一次。 该方法可以使用包括歧管段的SPTFF或TFF系统来执行，以串行化进料和滞留物的流动路径，而不需要转向板。