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公开(公告)号：US12168016B2
公开(公告)日：2024-12-17
申请号：US18606946
申请日：2024-03-15
Applicant: Epizyme, Inc.
Inventor： Kevin W. Kuntz , Richard Chesworth , Kenneth W. Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah K. Knutson , Timothy J. N. Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US12161645B2
公开(公告)日：2024-12-10
申请号：US18606903
申请日：2024-03-15
Applicant: Epizyme, Inc.
Inventor： Kevin W. Kuntz , Richard Chesworth , Kenneth W. Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah K. Knutson , Timothy J. N. Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US11951109B2
公开(公告)日：2024-04-09
申请号：US17526307
申请日：2021-11-15
Applicant: Epizyme, Inc.
Inventor： Heike Keilhack , Sarah Kathleen Knutson , Danielle Johnston Blackwell
IPC: A61K31/5377 , A61K31/4412 , A61K31/444 , A61K31/475 , A61K31/573 , A61K31/675 , A61K31/704 , A61K39/395 , A61K45/06 , A61P35/00 , G01N33/574
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/444 , A61K31/475 , A61K31/573 , A61K31/675 , A61K31/704 , A61K39/39558 , A61K45/06 , A61P35/00 , G01N33/57407 , A61K31/5377 , A61K2300/00 , A61K31/675 , A61K2300/00 , A61K31/704 , A61K2300/00 , A61K31/475 , A61K2300/00 , A61K31/573 , A61K2300/00 , A61K39/39558 , A61K2300/00
Abstract: The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US11370781B2
公开(公告)日：2022-06-28
申请号：US16985404
申请日：2020-08-05
Applicant: Epizyme, Inc.
Inventor： Heike Keilhack , Sarah Kathleen Knutson , Kevin Wayne Kuntz
IPC: A61K31/5355 , C07D213/64 , A61K31/4412 , C07D413/14 , A61P35/00 , C07D405/12 , A61K45/06 , A61K31/436 , A61K31/53 , A61K31/573 , A61K31/704 , A61K31/7068 , A61K31/5377 , A61K31/4439 , A61K31/444 , A61K33/243 , A61K31/4745 , A61K31/675
Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US10786511B2
公开(公告)日：2020-09-29
申请号：US15527375
申请日：2015-11-17
Applicant: Epizyme, Inc. , Eisai R&D Management Co., Ltd.
Inventor： Heike Keilhack , Brett Truitt , Yuta Suzuki , Tsukasa Murase , Futoshi Shikata
IPC: A61K31/5377 , A61K9/00 , A61K9/20 , A61K33/06 , A61K9/28
Abstract: The present invention relates to pharmaceutical compositions comprising inhibitor(s) of human histone methyltransferase EZH2, and methods of cancer therapy using the EZH2 inhibitor(s).
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Patent Agency Ranking
公开(公告)号：US10301290B2
公开(公告)日：2019-05-28
申请号：US14394463
申请日：2013-04-12
Applicant: EPIZYME, INC.
Inventor： Heike Keilhack , Sarah Kathleen Knutson , Kevin Wayne Kuntz
IPC: C07D213/64 , A61K31/4412 , C07D405/12 , A61K31/5377 , A61K45/06 , A61K31/436 , A61K31/53 , A61K31/573 , A61K31/704 , A61K31/7068 , A61K31/4745 , A61K31/675 , A61K33/24
Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US20180133224A1
公开(公告)日：2018-05-17
申请号：US15851978
申请日：2017-12-22
Applicant: Epizyme, Inc.
Inventor： Heike Keilhack
IPC: A61K31/5377 , A61K31/453
CPC classification number: A61K31/5377 , A61K31/45 , A61K31/453 , A61K31/5375 , A61K45/06 , A61P35/00 , A61P37/00
Abstract: The present invention provides a method for treating or alleviating a symptom of a disorder, e.g., immune evasion, cancer-cell induced immune dysfunction, reduced immune response, lowered inflammation, decreased expression of a major histocompatibility complex (MHC), or cancer, characterized by aberrant, misregulated, or increased Enhancer of Zeste Homolog 2 (EZH2) activity in a cell or subject in need thereof by contacting the cell or administering to the subject a therapeutically effective amount of an EZH2 inhibitor.
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公开(公告)号：US09549931B2
公开(公告)日：2017-01-24
申请号：US14742481
申请日：2015-06-17
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: C07D213/64 , C07D405/14 , C07D498/08 , A61K31/5377 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US09522152B2
公开(公告)日：2016-12-20
申请号：US14876658
申请日：2015-10-06
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377 , C07D498/08 , C07D213/64 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D405/14
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20160022693A1
公开(公告)日：2016-01-28
申请号：US14876658
申请日：2015-10-06
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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