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公开(公告)号：US20050130943A1
公开(公告)日：2005-06-16
申请号：US10992470
申请日：2004-11-18
申请人： Eli Wallace , Joseph Lyssikatos , Hong Yang
发明人： Eli Wallace , Joseph Lyssikatos , Hong Yang
IPC分类号： A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
CPC分类号： C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, R10, R20, R21, and R22 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了式I化合物及其药学上可接受的盐和前药，其中R 1，R 2，R 7，R 4， 8，R 9，R 10，R 20，R 21和R SUP > 22 如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物和炎性病症中的过度增殖性疾病，例如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。
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公开(公告)号：US09527865B2
公开(公告)日：2016-12-27
申请号：US13607016
申请日：2012-09-07
IPC分类号： C07D239/94 , C07D498/10 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C04B35/632
摘要： This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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公开(公告)号：US20130245256A1
公开(公告)日：2013-09-19
申请号：US13607016
申请日：2012-09-07
IPC分类号： C07D498/10 , C07D498/04 , C07D413/12 , C07D239/94 , C07D401/12
CPC分类号： C07D498/10 , C04B35/632 , C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04
摘要： This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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公开(公告)号：US08278314B2
公开(公告)日：2012-10-02
申请号：US12249421
申请日：2008-10-10
IPC分类号： C07D239/94 , A61K31/517 , A61P35/00
CPC分类号： C07D239/94 , C04B35/632 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供式I的喹唑啉类似物：其中A与双环的5,6,7或8位上的至少一个碳键合，并且该环被至多两个独立的R 3基团取代。 本发明还包括使用式I化合物作为I型受体酪氨酸激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20050101616A1
公开(公告)日：2005-05-12
申请号：US10642440
申请日：2003-08-14
IPC分类号： C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C07D498/08 , A61K31/517 , A61K31/47 , C07D43/02
CPC分类号： C07D498/10 , C04B35/632 , C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04
摘要： This invention concerns quinazoline analogs of Formula I: where an A group is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to three independent R3 groups. The invention also includes methods of using these compounds as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明涉及式I的喹唑啉类似物：其中A基团与双环的5,6,7或8位上的至少一个碳键合，并且该环被多达三个独立的R“ > 3个组。 本发明还包括使用这些化合物作为I型受体酪氨酸激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20050043334A1
公开(公告)日：2005-02-24
申请号：US10914974
申请日：2004-08-10
IPC分类号： C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C07D498/08 , A61K31/517 , A61K31/47 , C07D215/38
CPC分类号： C07D239/94 , C04B35/632 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供式I的喹唑啉类似物：其中A与双环的5,6,7或8位上的至少一个碳键合，并且该环被至多两个独立的R 3基团取代 。 本发明还包括使用式I化合物作为I型受体酪氨酸激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20090270621A1
公开(公告)日：2009-10-29
申请号：US12496973
申请日：2009-07-02
IPC分类号： C07D413/12 , C07D239/72 , C07D403/12
CPC分类号： C07D498/10 , C04B35/632 , C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04
摘要： This invention concerns quinazoline analogs of Formula I: where an A group is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to three independent R3 groups. The invention also includes methods of using these compounds as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明涉及式I的喹唑啉类似物：其中A基团与双环的5,6,7或8位上的至少一个碳键合，并且该环被多达三个独立的R 3基团取代。 本发明还包括使用这些化合物作为I型受体酪氨酸激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US07585975B2
公开(公告)日：2009-09-08
申请号：US12081725
申请日：2008-04-21
IPC分类号： C07D239/00 , C07D239/70 , C07D471/00 , C07D487/00
CPC分类号： C07D498/10 , C04B35/632 , C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04
摘要： This invention concerns quinazoline analogs of Formula I: where an A group is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to three independent R3 groups. The invention also includes methods of using these compounds as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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公开(公告)号：US07452895B2
公开(公告)日：2008-11-18
申请号：US10914974
申请日：2004-08-10
IPC分类号： A61K31/517 , C07D239/94
CPC分类号： C07D239/94 , C04B35/632 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供式I的喹唑啉类似物：其中A与双环的5,6,7或8位上的至少一个碳键合，并且该环被至多两个独立的R 3取代 组。 本发明还包括使用式I化合物作为I型受体酪氨酸激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20070299063A1
公开(公告)日：2007-12-27
申请号：US11762897
申请日：2007-06-14
申请人： Eli Wallace , Joseph Lyssikatos , Allison Marlow , T. Hurley , Kevin Koch
发明人： Eli Wallace , Joseph Lyssikatos , Allison Marlow , T. Hurley , Kevin Koch
IPC分类号： A61K31/54 , A61P29/00 , A61P35/00 , C07D211/32 , C07D235/04 , C07D401/02 , C07D403/02 , C07D413/02 , C07D417/02
CPC分类号： C07D235/06 , C04B35/632 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12 , C07F9/65068 , C07F9/65586
摘要： Disclosed are amino acid prodrugs of compounds of the formula I and pharmaceutically acceptable salts thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了式I化合物及其药学上可接受的盐的氨基酸前药，其中W 1，R 2，R 2，R 7， R 8，R 9和R 10如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，例如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法，以及含有这些化合物的药物组合物。
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