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21.发明申请公开(公告)号：US20120238767A1
公开(公告)日：2012-09-20
申请号：US13294504
申请日：2011-11-11
IPC分类号： C07C255/47 , C07C255/64 , C07C255/67
CPC分类号： C07J63/008
摘要： Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.
摘要翻译： 本文公开了新的齐墩果酸衍生物。 还公开了制备这些化合物的方法。 本发明的齐墩果酸衍生物可用于治疗和预防许多疾病，包括癌症，神经障碍，炎症和涉及氧化应激的病态。
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22.发明申请公开(公告)号：US20100048911A1
公开(公告)日：2010-02-25
申请号：US12426791
申请日：2009-04-20
IPC分类号： C07D257/04 , C07C69/74 , C07C233/57 , C07C49/29
CPC分类号： C07J63/008
摘要： Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.
摘要翻译： 本文公开了新的齐墩果酸衍生物。 还公开了制备这些化合物的方法。 本发明的齐墩果酸衍生物可用于治疗和预防许多疾病，包括癌症，神经障碍，炎症和涉及氧化应激的病态。
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23.发明授权公开(公告)号：US08338618B2
公开(公告)日：2012-12-25
申请号：US13294504
申请日：2011-11-11
IPC分类号： C07D257/04 , C07C69/74 , C07C233/57 , C07C49/29
CPC分类号： C07J63/008
摘要： Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.
摘要翻译： 本文公开了新的齐墩果酸衍生物。 还公开了制备这些化合物的方法。 本发明的齐墩果酸衍生物可用于治疗和预防许多疾病，包括癌症，神经障碍，炎症和涉及氧化应激的病态。
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24.发明授权公开(公告)号：US08071632B2
公开(公告)日：2011-12-06
申请号：US12426791
申请日：2009-04-20
IPC分类号： A61K31/4245 , C07D271/08
CPC分类号： C07J63/008
摘要： Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.
摘要翻译： 本文公开了新的齐墩果酸衍生物。 还公开了制备这些化合物的方法。 本发明的齐墩果酸衍生物可用于治疗和预防许多疾病，包括癌症，神经障碍，炎症和涉及氧化应激的病态。
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![Halo substituted benzo[b]thiophenes as therapeutic agents](/abs-image/US/2005/05/05/US20050096350A1/abs.jpg.150x150.jpg)
公开(公告)号：US20050096350A1
公开(公告)日：2005-05-05
申请号：US10935356
申请日：2004-09-07
IPC分类号： A61K31/41 , A61K31/454 , C07D409/12 , C07D409/14 , C07D49/14
CPC分类号： C07D409/14 , C07D409/12
摘要： The present invention provides benzo[b]thiophenes of Formula I: wherein R3, R4, R5, R6, R7, Y, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
摘要翻译： 本发明提供式I的苯并[b]噻吩：其中R 3，R 4，R 5，R 6， Y和L具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症（包括炎症）的试剂 疾病，心血管疾病和癌症。 还提供了包含一种或多种式I化合物的药物组合物。
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公开(公告)号：US20050004195A1
公开(公告)日：2005-01-06
申请号：US10860336
申请日：2004-06-03
申请人： Kimberly Para , Charles Stankovic , Melean Visnick
发明人： Kimberly Para , Charles Stankovic , Melean Visnick
CPC分类号： C07D403/12
摘要： The present invention provides indoles of Formula I: wherein R1 and R2 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
摘要翻译： 本发明提供式I的吲哚：其中R 1和R 2具有本说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症的试剂，包括 炎性疾病，心血管疾病和癌症。 还提供了包含一种或多种式I化合物的药物组合物。
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27.发明申请Cycloalkyl and heterocycloalkyl substituted benzothiophenes as therapeutic agents 审中-公开环烷基和杂环烷基取代的苯并噻吩作为治疗剂公开(公告)号：US20050020630A1
公开(公告)日：2005-01-27
申请号：US10860524
申请日：2004-06-03
申请人： Michael Connolly , Rocco Gogliotti , Helen Lee , Mark Plummer , Karen Sexton , Melean Visnick
发明人： Michael Connolly , Rocco Gogliotti , Helen Lee , Mark Plummer , Karen Sexton , Melean Visnick
IPC分类号： A61K31/41 , A61K31/454 , A61P11/00 , C07D409/12 , C07D409/14 , C07
CPC分类号： C07D409/12 , C07D409/14
摘要： The present invention provides benzo[b]thiophenes of Formula I: wherein R1, R2, R3, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
摘要翻译： 本发明提供式I的苯并[b]噻吩：其中R 1，R 2，R 3和L具有本说明书中定义的任何值及其药学上可接受的盐，其为 可用作治疗疾病和病症（包括炎性疾病，心血管疾病和癌症）的药剂。 还提供了包含一种或多种式I化合物的药物组合物。
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公开(公告)号：US08778990B2
公开(公告)日：2014-07-15
申请号：US13127551
申请日：2009-10-29
申请人： Tadashi Honda , Michael B. Sporn , Karen T. Liby , Gordon W. Gribble , Robert M. Kral, Jr. , Melean Visnick
发明人： Tadashi Honda , Michael B. Sporn , Karen T. Liby , Gordon W. Gribble , Robert M. Kral, Jr. , Melean Visnick
IPC分类号： A61K31/277 , A61K48/00 , A61N5/00 , A61P35/00
CPC分类号： C07J41/0033 , C07J41/0055
摘要： This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Treatment methods and methods of manufacture are also provided.
摘要翻译： 本发明的特征在于具有下式的桦木酸衍生物：其中变量在本文中定义。 本发明还提供了相关的化合物及其中间体，以及包含这些化合物的药物组合物，试剂盒和制品。 还提供了处理方法和制造方法。
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公开(公告)号：US07074814B2
公开(公告)日：2006-07-11
申请号：US10860336
申请日：2004-06-03
IPC分类号： C07D257/06 , C07D209/12 , A61K31/405 , A61K31/41
CPC分类号： C07D403/12
摘要： The present invention provides indoles of Formula I: wherein R1 and R2 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
摘要翻译： 本发明提供式I的吲哚：其中R 1和R 2 2具有本说明书中定义的任何值及其药学上可接受的盐，其可用作 治疗疾病和病症的药物，包括炎性疾病，心血管疾病和癌症。 还提供了包含一种或多种式I化合物的药物组合物。
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30.发明申请公开(公告)号：US20090227587A1
公开(公告)日：2009-09-10
申请号：US11664975
申请日：2004-10-19
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D403/04 , C07D403/12
摘要： The present invention provides pyrimidines of Formula I: wherein R4, R6, and Y have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
摘要翻译： 本发明提供式I的嘧啶：其中R4，R6和Y具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症（包括炎性疾病）的药剂， 心血管疾病和癌症。 还提供了包含一种或多种式I化合物的药物组合物。
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