-
公开(公告)号：US20050004195A1
公开(公告)日：2005-01-06
申请号：US10860336
申请日：2004-06-03
申请人： Kimberly Para , Charles Stankovic , Melean Visnick
发明人： Kimberly Para , Charles Stankovic , Melean Visnick
CPC分类号： C07D403/12
摘要： The present invention provides indoles of Formula I: wherein R1 and R2 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
摘要翻译： 本发明提供式I的吲哚：其中R 1和R 2具有本说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症的试剂，包括 炎性疾病，心血管疾病和癌症。 还提供了包含一种或多种式I化合物的药物组合物。
-
2.发明申请ANTIOXIDANT INFLAMMATION MODULATORS: C-17 HOMOLOGATED OLEANOLIC ACID DERIVATIVES 有权抗氧化剂消炎调节剂：C-17同型异亮氨酸衍生物公开(公告)号：US20100041904A1
公开(公告)日：2010-02-18
申请号：US12426832
申请日：2009-04-20
申请人： Xin Jiang , Xiaofeng Liu , Jack Greiner , Stephen S. Szucs , Melean Visnick
发明人： Xin Jiang , Xiaofeng Liu , Jack Greiner , Stephen S. Szucs , Melean Visnick
IPC分类号： C07D307/77 , C07C229/00 , C07D261/06 , C07D257/04
CPC分类号： C07C255/47 , C07C53/18 , C07D209/48 , C07D257/04 , C07D261/08 , C07D303/36 , C07D317/28 , C07D493/08 , C07F9/09 , C07J63/008
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
摘要翻译： 本发明提供但不限于具有下式的新型齐墩果酸衍生物：其中变量在本文中定义。 还提供了包含这种化合物的药物组合物，试剂盒和制品，用于制备化合物的方法和中间体，以及使用该化合物和组合物的方法。
-
![Halo substituted benzo[b]thiophenes as therapeutic agents](/abs-image/US/2005/05/05/US20050096350A1/abs.jpg.150x150.jpg)
公开(公告)号：US20050096350A1
公开(公告)日：2005-05-05
申请号：US10935356
申请日：2004-09-07
IPC分类号： A61K31/41 , A61K31/454 , C07D409/12 , C07D409/14 , C07D49/14
CPC分类号： C07D409/14 , C07D409/12
摘要： The present invention provides benzo[b]thiophenes of Formula I: wherein R3, R4, R5, R6, R7, Y, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
摘要翻译： 本发明提供式I的苯并[b]噻吩：其中R 3，R 4，R 5，R 6， Y和L具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症（包括炎症）的试剂 疾病，心血管疾病和癌症。 还提供了包含一种或多种式I化合物的药物组合物。
-
4.发明申请公开(公告)号：US20120238767A1
公开(公告)日：2012-09-20
申请号：US13294504
申请日：2011-11-11
IPC分类号： C07C255/47 , C07C255/64 , C07C255/67
CPC分类号： C07J63/008
摘要： Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.
摘要翻译： 本文公开了新的齐墩果酸衍生物。 还公开了制备这些化合物的方法。 本发明的齐墩果酸衍生物可用于治疗和预防许多疾病，包括癌症，神经障碍，炎症和涉及氧化应激的病态。
-
5.发明授权Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring 有权抗氧化剂炎症调节剂：C环中饱和的齐墩果酸衍生物公开(公告)号：US08124656B2
公开(公告)日：2012-02-28
申请号：US13033452
申请日：2011-02-23
申请人： Eric Anderson , Xin Jiang , Xiaofeng Liu , Melean Visnick
发明人： Eric Anderson , Xin Jiang , Xiaofeng Liu , Melean Visnick
IPC分类号： A61K31/21 , C07C61/125
CPC分类号： C07D261/20 , C07C69/757 , C07D207/27 , C07D413/08 , C07J63/008
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
摘要翻译： 本发明提供但不限于具有下式的新型齐墩果酸衍生物：其中变量在本文中定义。 还提供了包含这种化合物的药物组合物，试剂盒和制品，用于制备化合物的方法和中间体，以及使用该化合物和组合物的方法。
-
6.发明申请ANTIOXIDANT INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH SATURATION IN THE C-RING 有权抗氧化剂溶解调节剂：在C环中饱和的油酸衍生物公开(公告)号：US20100056777A1
公开(公告)日：2010-03-04
申请号：US12426737
申请日：2009-04-20
申请人： Eric Anderson , Xin Jiang , Xiaofeng Liu , Melean Visnick
发明人： Eric Anderson , Xin Jiang , Xiaofeng Liu , Melean Visnick
IPC分类号： C07D223/14 , C07C61/08 , C07C233/57 , C07C49/303 , C07C69/74 , C07C243/12 , C07D257/04 , C07D285/12 , C07D271/10 , C07D313/06
CPC分类号： C07D261/20 , C07C69/757 , C07D207/27 , C07D413/08 , C07J63/008
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
摘要翻译： 本发明提供但不限于具有下式的新型齐墩果酸衍生物：其中变量在本文中定义。 还提供了包含这种化合物的药物组合物，试剂盒和制品，用于制备化合物的方法和中间体，以及使用该化合物和组合物的方法。
-
7.发明申请Cycloalkyl and heterocycloalkyl substituted benzothiophenes as therapeutic agents 审中-公开环烷基和杂环烷基取代的苯并噻吩作为治疗剂公开(公告)号：US20050020630A1
公开(公告)日：2005-01-27
申请号：US10860524
申请日：2004-06-03
申请人： Michael Connolly , Rocco Gogliotti , Helen Lee , Mark Plummer , Karen Sexton , Melean Visnick
发明人： Michael Connolly , Rocco Gogliotti , Helen Lee , Mark Plummer , Karen Sexton , Melean Visnick
IPC分类号： A61K31/41 , A61K31/454 , A61P11/00 , C07D409/12 , C07D409/14 , C07
CPC分类号： C07D409/12 , C07D409/14
摘要： The present invention provides benzo[b]thiophenes of Formula I: wherein R1, R2, R3, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
摘要翻译： 本发明提供式I的苯并[b]噻吩：其中R 1，R 2，R 3和L具有本说明书中定义的任何值及其药学上可接受的盐，其为 可用作治疗疾病和病症（包括炎性疾病，心血管疾病和癌症）的药剂。 还提供了包含一种或多种式I化合物的药物组合物。
-
公开(公告)号：US08778990B2
公开(公告)日：2014-07-15
申请号：US13127551
申请日：2009-10-29
申请人： Tadashi Honda , Michael B. Sporn , Karen T. Liby , Gordon W. Gribble , Robert M. Kral, Jr. , Melean Visnick
发明人： Tadashi Honda , Michael B. Sporn , Karen T. Liby , Gordon W. Gribble , Robert M. Kral, Jr. , Melean Visnick
IPC分类号： A61K31/277 , A61K48/00 , A61N5/00 , A61P35/00
CPC分类号： C07J41/0033 , C07J41/0055
摘要： This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Treatment methods and methods of manufacture are also provided.
摘要翻译： 本发明的特征在于具有下式的桦木酸衍生物：其中变量在本文中定义。 本发明还提供了相关的化合物及其中间体，以及包含这些化合物的药物组合物，试剂盒和制品。 还提供了处理方法和制造方法。
-
公开(公告)号：US08513436B2
公开(公告)日：2013-08-20
申请号：US13330378
申请日：2011-12-19
申请人： Eric Anderson , Gary L. Bolton , Bradley Caprathe , Xin Jiang , Chitase Lee , William H. Roark , Melean Visnick
发明人： Eric Anderson , Gary L. Bolton , Bradley Caprathe , Xin Jiang , Chitase Lee , William H. Roark , Melean Visnick
IPC分类号： C07D487/00 , C07D239/70 , C07D271/06 , C07D271/10 , C07D261/02 , C07D257/04
CPC分类号： C07C255/47 , C07D231/54 , C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.
-
公开(公告)号：US20120283450A1
公开(公告)日：2012-11-08
申请号：US13552530
申请日：2012-07-18
申请人： Eric Anderson , Gary L. Bolton , Deborah A. Ferguson , Xin Jiang , Robert M. Kral, JR. , Patrick M. O'Brien , Melean Visnick
发明人： Eric Anderson , Gary L. Bolton , Deborah A. Ferguson , Xin Jiang , Robert M. Kral, JR. , Patrick M. O'Brien , Melean Visnick
IPC分类号： C07C255/46 , C07F7/10 , C07J21/00 , C07J71/00 , C07J41/00 , C07D317/30 , C07D311/62
CPC分类号： C07C255/46 , C07C2601/16 , C07D311/74 , C07D317/26 , C07D493/10 , C07F7/1804 , C07J21/003 , C07J41/0055 , C07J41/0094 , C07J53/001 , C07J71/0005
摘要： This invention provides novel compounds comprising the following anti-inflammatory pharmacore: wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
摘要翻译： 本发明提供包含以下抗炎药物的新化合物：其中X，R 1和R 2在本文中定义。 还提供了包含这种化合物的药物组合物，试剂盒和制品，用于制备化合物的方法和中间体，以及使用该化合物和组合物的方法。
-
-
-
-
-
-
-
-
-
搜索结果
33 条记录 (耗时 0.03 秒)
