-
公开(公告)号：US5889034A
公开(公告)日：1999-03-30
申请号：US40777
申请日：1998-03-18
Applicant: Gary Louis Bolton , John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti , Terri Stoeber Purchase , Joseph Peter Sanchez , Bharat Kalidas Trivedi
Inventor： Gary Louis Bolton , John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti , Terri Stoeber Purchase , Joseph Peter Sanchez , Bharat Kalidas Trivedi
IPC: C07D275/04 , C07D513/04 , A61K31/41
CPC classification number: C07D275/04 , C07D513/04
Abstract: Isothiazolones having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.
Abstract translation: 具有一般结构
的异噻唑酮，其中A是可以含有至多3个选自O，S和N的杂原子的单环或双环; R1和R2是取代基，例如烷基，烷氧基，羟基，硝基，氰基，氨基和羧基; R5是烷基，环烷基，苯基和Het。 异噻唑酮可用作抗逆转录病毒剂，抗炎剂和抗动脉粥样硬化剂。 -
公开(公告)号：US5733921A
公开(公告)日：1998-03-31
申请号：US757716
申请日：1996-11-26
Applicant: Gary Louis Bolton , John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti , Terri Stoeber Purchase , Joseph Peter Sanchez , Bharat Kalidas Trivedi
Inventor： Gary Louis Bolton , John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti , Terri Stoeber Purchase , Joseph Peter Sanchez , Bharat Kalidas Trivedi
IPC: A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , A61P9/10 , A61P29/00 , A61P31/12 , A61P31/14 , C07D275/04 , C07D417/04 , C07D513/04 , C07D513/14 , A61K31/41
CPC classification number: C07D275/04 , C07D513/04 , C07D513/14
Abstract: Isothiazolones having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.
Abstract translation: 具有一般结构
的异噻唑酮，其中A是可以含有至多3个选自O，S和N的杂原子的单环或双环; R1和R2是取代基，例如烷基，烷氧基，羟基，硝基，氰基，氨基和羧基; R5是烷基，环烷基，苯基和Het。 异噻唑酮可用作抗逆转录病毒剂，抗炎剂和抗动脉粥样硬化剂。 -
公开(公告)号：US6133270A
公开(公告)日：2000-10-17
申请号：US882846
申请日：1997-06-26
Applicant: Gary Louis Bolton , John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti , Terri Stoeber Purchase , Joseph Peter Sanchez , Bharat Kalidas Trivedi
Inventor： Gary Louis Bolton , John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti , Terri Stoeber Purchase , Joseph Peter Sanchez , Bharat Kalidas Trivedi
IPC: A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , A61P9/10 , A61P29/00 , A61P31/12 , A61P31/14 , C07D275/04 , C07D417/04 , C07D513/04 , C07D513/14 , A61K31/505
CPC classification number: C07D275/04 , C07D513/04 , C07D513/14
Abstract: Isothiazolones having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.
Abstract translation: 具有一般结构的异噻唑酮，其中A是可以含有至多3个选自O，S和N的杂原子的单环或双环; R1和R2是取代基，例如烷基，烷氧基，羟基，硝基，氰基，氨基和羧基; R5是烷基，环烷基，苯基和Het。 异噻唑酮可用作抗逆转录病毒剂，抗炎剂和抗动脉粥样硬化剂。
-
![Pyrrolyl Substituted Pyrido[2,3-D]Pyrimidin-7-Ones and Derivatives Thereof as Therapeutic Agents](/abs-image/US/2008/10/16/US20080255162A1/abs.jpg.150x150.jpg)
4.发明申请Pyrrolyl Substituted Pyrido[2,3-D]Pyrimidin-7-Ones and Derivatives Thereof as Therapeutic Agents 审中-公开吡咯基取代的吡啶并[2,3-D]嘧啶-7-酮及其衍生物作为治疗剂公开(公告)号：US20080255162A1
公开(公告)日：2008-10-16
申请号：US11568611
申请日：2005-04-22
Applicant: Michelle Marie Bruendl , Rocco Dean Gogliotti , Annise Paige Goodman , Gregory Adam Reichard
Inventor： Michelle Marie Bruendl , Rocco Dean Gogliotti , Annise Paige Goodman , Gregory Adam Reichard
IPC: A61K31/519 , C07D471/04 , A61P3/00 , A61P19/00 , A61P11/00 , A61P35/04
CPC classification number: C07D471/04
Abstract: The present invention provides pyrimidines of Formula I: wherein R2, R4, R5, R6, R8 and J have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
Abstract translation: 本发明提供式I的嘧啶：其中R 2，R 4，R 5，R 6， R 8和J具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病（包括炎性疾病，心血管疾病和癌症）的药剂。 还提供了包含一种或多种式I化合物的药物组合物。
-
公开(公告)号：US6001863A
公开(公告)日：1999-12-14
申请号：US882845
申请日：1997-06-26
Applicant: Gary Louis Bolton , John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti , Terri Stoeber Purchase , Joseph Peter Sanchez , Bharat Kalidas Trivedi
Inventor： Gary Louis Bolton , John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti , Terri Stoeber Purchase , Joseph Peter Sanchez , Bharat Kalidas Trivedi
IPC: C07D275/04 , C07D513/04 , A61K31/41
CPC classification number: C07D275/04 , C07D513/04
Abstract: Isothiazolones having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.
Abstract translation: 具有一般结构的异噻唑酮，其中A是可以含有至多3个选自O，S和N的杂原子的单环或双环; R1和R2是取代基，例如烷基，烷氧基，羟基，硝基，氰基，氨基和羧基; R5是烷基，环烷基，苯基和Het。 异噻唑酮可用作抗逆转录病毒剂，抗炎剂和抗动脉粥样硬化剂。
-
Patent Agency Ranking
6.发明申请公开(公告)号：US20090227587A1
公开(公告)日：2009-09-10
申请号：US11664975
申请日：2004-10-19
Applicant: Michael Kevin Connolly , Rocco Dean Gogliotti , Mark Stephen Plummer , Melean Visnick
Inventor： Michael Kevin Connolly , Rocco Dean Gogliotti , Mark Stephen Plummer , Melean Visnick
IPC: A61K31/5377 , C07D413/14
CPC classification number: C07D403/04 , C07D403/12
Abstract: The present invention provides pyrimidines of Formula I: wherein R4, R6, and Y have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
Abstract translation: 本发明提供式I的嘧啶：其中R4，R6和Y具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症（包括炎性疾病）的药剂， 心血管疾病和癌症。 还提供了包含一种或多种式I化合物的药物组合物。
-
公开(公告)号：US5929114A
公开(公告)日：1999-07-27
申请号：US857116
申请日：1997-05-15
Applicant: John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti
Inventor： John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti
IPC: C07D295/16 , A61K31/105 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/195 , A61K31/198 , A61K31/215 , A61K31/216 , A61K31/225 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/495 , A61K31/54 , A61K31/63 , A61K38/00 , A61P31/04 , A61P31/12 , C07C323/22 , C07C323/47 , C07C323/62 , C07C323/63 , C07C323/65 , C07C323/67 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/82 , C07D239/42 , C07D239/69 , C07D295/13 , C07D295/18 , C07D295/192 , C07D295/205 , C07D333/20 , C07D333/36 , C07D333/38 , C07D521/00 , C07F9/40 , C07K5/06 , A01N37/20
CPC classification number: C07D207/08 , A61K31/166 , A61K31/167 , A61K31/198 , A61K31/216 , A61K31/225 , A61K31/63 , C07C323/22 , C07C323/47 , C07C323/62 , C07C323/63 , C07C323/65 , C07C323/67 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/62 , C07D213/82 , C07D239/42 , C07D239/69 , C07D295/13 , C07D295/192 , C07D295/205 , C07D333/20 , C07F9/4056 , C07K5/06043 , A61K38/00 , C07C2101/02 , C07C2101/14
Abstract: Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O, S, and N,R.sup.1 and R.sup.2 are substituent groups, X is ##STR2## or SO.sub.2 NR.sup.4 Z, Y is H or SZ when n is 1, a single bond when n is 2; R.sup.4 and Z can be hydrogen or alkyl.
Abstract translation: 芳硫醇和二硫代二芳基酰胺抗菌和抗病毒剂具有以下通式：其中A是可以含有至多3个选自O，S和N的杂原子的单环或双环芳基，R 1和R 2是取代基，X是或SO 2 NR 4 Z，Y是H或 当n为1时为SZ，n为2时为单键; R4和Z可以是氢或烷基。
-
公开(公告)号：US5734081A
公开(公告)日：1998-03-31
申请号：US446917
申请日：1995-06-01
Applicant: John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti
Inventor： John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti
IPC: C07D295/16 , A61K31/105 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/195 , A61K31/198 , A61K31/215 , A61K31/216 , A61K31/225 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/495 , A61K31/54 , A61K31/63 , A61K38/00 , A61P31/04 , A61P31/12 , C07C323/22 , C07C323/47 , C07C323/62 , C07C323/63 , C07C323/65 , C07C323/67 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/82 , C07D239/42 , C07D239/69 , C07D295/13 , C07D295/18 , C07D295/192 , C07D295/205 , C07D333/20 , C07D333/36 , C07D333/38 , C07D521/00 , C07F9/40 , C07K5/06 , C07C303/00
CPC classification number: C07D207/08 , A61K31/166 , A61K31/167 , A61K31/198 , A61K31/216 , A61K31/225 , A61K31/63 , C07C323/22 , C07C323/47 , C07C323/62 , C07C323/63 , C07C323/65 , C07C323/67 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/62 , C07D213/82 , C07D239/42 , C07D239/69 , C07D295/13 , C07D295/192 , C07D295/205 , C07D333/20 , C07F9/4056 , C07K5/06043 , A61K38/00 , C07C2101/02 , C07C2101/14
Abstract: Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O, S, and N, R.sup.1 and R.sup.2 are substituent groups, X is ##STR2## or SO.sub.2 NR.sup.4 Z, Y is H or SZ when n is 1, a single bond when n is 2; R.sup.4 and Z can be hydrogen or alkyl.
Abstract translation: 芳硫醇和二硫代双芳酰胺抗菌和抗病毒剂具有通式
，其中A是可以含有至多3个选自O，S和N的杂原子的单环或双环芳基，R 1和R 2是取代基，X是<或> SO2NR4Z，当n为1时，Y为H或SZ，n为2时为单键; R4和Z可以是氢或烷基。 -
公开(公告)号：US5668291A
公开(公告)日：1997-09-16
申请号：US474875
申请日：1995-06-07
Applicant: John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti
Inventor： John Michael Domagala , Edward Faith Elslager , Rocco Dean Gogliotti
IPC: C07D295/16 , A61K31/105 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/195 , A61K31/198 , A61K31/215 , A61K31/216 , A61K31/225 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/495 , A61K31/54 , A61K31/63 , A61K38/00 , A61P31/04 , A61P31/12 , C07C323/22 , C07C323/47 , C07C323/62 , C07C323/63 , C07C323/65 , C07C323/67 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/82 , C07D239/42 , C07D239/69 , C07D295/13 , C07D295/18 , C07D295/192 , C07D295/205 , C07D333/20 , C07D333/36 , C07D333/38 , C07D521/00 , C07F9/40 , C07K5/06 , C07D213/56
CPC classification number: C07D207/08 , A61K31/166 , A61K31/167 , A61K31/198 , A61K31/216 , A61K31/225 , A61K31/63 , C07C323/22 , C07C323/47 , C07C323/62 , C07C323/63 , C07C323/65 , C07C323/67 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/62 , C07D213/82 , C07D239/42 , C07D239/69 , C07D295/13 , C07D295/192 , C07D295/205 , C07D333/20 , C07F9/4056 , C07K5/06043 , A61K38/00 , C07C2101/02 , C07C2101/14
Abstract: Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O, S, and N, R.sup.1 and R.sup.2 are substituent groups, X is ##STR2## or SO.sub.2 NR.sup.4 Z, Y is H or SZ when n is 1, a single bond when n is 2; R.sup.4 and Z can be hydrogen or alkyl.
Abstract translation: 芳硫醇和二硫代双芳酰胺抗菌和抗病毒剂具有通式
，其中A是可以含有至多3个选自O，S和N的杂原子的单环或双环芳基，R 1和R 2是取代基，X是<或> SO2NR4Z，当n为1时，Y为H或SZ，n为2时为单键; R4和Z可以是氢或烷基。 -
公开(公告)号：US5668178A
公开(公告)日：1997-09-16
申请号：US444974
申请日：1995-05-19
Applicant: Edward Faith Elslager , Rocco Dean Gogliotti
Inventor： Edward Faith Elslager , Rocco Dean Gogliotti
IPC: A61K31/13 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/198 , A61K31/216 , A61K31/225 , A61K31/435 , A61K31/495 , A61K31/66 , A61K38/00 , C07C321/26 , C07C321/28 , C07C323/22 , C07C323/47 , C07C323/62 , C07C323/63 , C07C323/65 , C07C323/67 , C07D207/00 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/62 , C07D213/71 , C07D213/82 , C07D239/42 , C07D239/69 , C07D295/10 , C07D295/13 , C07D295/192 , C07D295/205 , C07D333/20 , C07F9/38 , C07F9/40 , C07K5/06 , A01N37/18
CPC classification number: C07D207/08 , A61K31/166 , A61K31/167 , A61K31/198 , A61K31/216 , A61K31/225 , C07C323/22 , C07C323/47 , C07C323/62 , C07C323/63 , C07C323/65 , C07C323/67 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/62 , C07D213/82 , C07D239/42 , C07D239/69 , C07D295/13 , C07D295/192 , C07D295/205 , C07D333/20 , C07F9/4056 , C07K5/06043 , A61K38/00 , C07C2101/02 , C07C2101/14
Abstract: Phenylthiols and dithiobisbenzamides are potent antibacterial and antiviral agents.
Abstract translation: 苯硫醇和二硫代双苯甲酰胺是有效的抗菌和抗病毒剂。
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.015 seconds)
