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公开(公告)号：US11738196B2
公开(公告)日：2023-08-29
申请号：US17872432
申请日：2022-07-25
Applicant: Galvani Bioelectronics Limited
Inventor： Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
CPC classification number: A61N1/3606 , A61N1/0556 , A61N1/3614 , A61N1/36135 , A61N1/36139 , A61N1/36171 , A61N1/36178 , A61N2001/083
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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Patent Agency Ranking
公开(公告)号：US20220409890A1
公开(公告)日：2022-12-29
申请号：US17872829
申请日：2022-07-25
Applicant: Galvani Bioelectronics Limited
Inventor： Matteo Donega , Daniel John Chew , Margarita J. Vervoordeldonk , Isha Gupta
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
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公开(公告)号：US11452867B2
公开(公告)日：2022-09-27
申请号：US16955331
申请日：2018-12-20
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Matteo Donega , Daniel John Chew , Margarita J. Vervoordeldonk , Isha Gupta
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
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公开(公告)号：US11446502B2
公开(公告)日：2022-09-20
申请号：US16955264
申请日：2018-12-20
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Matteo Donega , Daniel John Chew , Isha Gupta
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.
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公开(公告)号：US20220080208A1
公开(公告)日：2022-03-17
申请号：US17415599
申请日：2019-12-13
Applicant: Galvani Bioelectronics Limited
Inventor： David Karl Lee Peterson , Daniel John Chew , Matteo Donega , Xu Meng
Abstract: A system (1) for electrically stimulating a nerve (3), the system comprising: a first stimulator (5) and a second stimulator (7) for electrically stimulating the nerve, the first stimulator and the second stimulator spaced apart from one another by a first distance; and a controller (9) arranged to: a) set a time interval as a function of the first distance and the speed of propagation of an action potential in the nerve; b) activate the first stimulator for a first stimulation period, thus inducing electrical activity in the nerve; and c) activate the second stimulator for a second stimulation period after the time interval has elapsed after the end of the first time period. Preferably, the time interval is a sum of the first time period and a buffer time period for allowing the nerve to recover from stimulation.
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公开(公告)号：US10974041B2
公开(公告)日：2021-04-13
申请号：US15568964
申请日：2016-04-22
Applicant: GALVANI BIOELECTRONICS LIMITED , ACADEMISCH MEDISCH CENTRUM
Inventor： Daniel John Chew , Wouter Jacob De Jonge , Hans Jakob Kristoffer Famm , Sonal Patel , Olaf Welting
Abstract: The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.
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