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公开(公告)号：US10974041B2
公开(公告)日：2021-04-13
申请号：US15568964
申请日：2016-04-22
发明人： Daniel John Chew , Wouter Jacob De Jonge , Hans Jakob Kristoffer Famm , Sonal Patel , Olaf Welting
摘要： The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.
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公开(公告)号：US12083340B2
公开(公告)日：2024-09-10
申请号：US18141045
申请日：2023-04-28
发明人： Daniel John Chew , Matteo Donega , Isha Gupta
CPC分类号： A61N1/36071 , A61N1/0553 , A61N1/0556 , A61N1/205 , A61N1/36135 , A61N1/3616 , A61N1/36171
摘要： Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.
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公开(公告)号：US11724102B2
公开(公告)日：2023-08-15
申请号：US17872829
申请日：2022-07-25
CPC分类号： A61N1/0556 , A61N1/0553 , A61N1/36053 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36135 , A61N1/36171 , A61N1/3787
摘要： Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
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公开(公告)号：US20220409895A1
公开(公告)日：2022-12-29
申请号：US17872432
申请日：2022-07-25
发明人： Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
摘要： Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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公开(公告)号：US20230271010A1
公开(公告)日：2023-08-31
申请号：US18140387
申请日：2023-04-27
发明人： Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
CPC分类号： A61N1/3606 , A61N1/0556 , A61N1/36139 , A61N1/36178 , A61N1/36135 , A61N1/3614 , A61N1/36171 , A61N2001/083
摘要： Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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公开(公告)号：US11464978B2
公开(公告)日：2022-10-11
申请号：US16955345
申请日：2018-12-20
发明人： Daniel John Chew , Matteo Donega , Isha Gupta
摘要： Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
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公开(公告)号：US10603486B2
公开(公告)日：2020-03-31
申请号：US16309182
申请日：2017-06-12
摘要： Methods for fabricating implantable cuff electrodes for contacting or at least partially surrounding internal body tissue such as, e.g., nerves, smooth muscles, striated muscles, arteries, veins, ligamental tissues, connective tissues, cartilage tissues, bones, or other similar body tissues, structures and organs are disclosed. An example method includes preparing a substrate including an implantable cuff electrode shape, applying a mold material to the substrate, curing the mold material to form a mold, releasing the mold from the substrate, inserting at least one conductor into the mold that penetrates through the channel of the mold, pressing a formable material into the channel of the mold to form a body of an implantable cuff electrode about the at least one conductor, curing the body of the implantable cuff electrode, and releasing the body of the implantable cuff electrode from the mold.
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公开(公告)号：US12121718B2
公开(公告)日：2024-10-22
申请号：US18213964
申请日：2023-06-26
CPC分类号： A61N1/0556 , A61N1/0553 , A61N1/36053 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36135 , A61N1/36171 , A61N1/3787
摘要： Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
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公开(公告)号：US12036413B2
公开(公告)日：2024-07-16
申请号：US17415599
申请日：2019-12-13
CPC分类号： A61N1/36167 , A61N1/0551
摘要： A system (1) for electrically stimulating a nerve (3), the system comprising: a first stimulator (5) and a second stimulator (7) for electrically stimulating the nerve, the first stimulator and the second stimulator spaced apart from one another by a first distance; and a controller (9) arranged to: a) set a time interval as a function of the first distance and the speed of propagation of an action potential in the nerve; b) activate the first stimulator for a first stimulation period, thus inducing electrical activity in the nerve; and c) activate the second stimulator for a second stimulation period after the time interval has elapsed after the end of the first time period. Preferably, the time interval is a sum of the first time period and a buffer time period for allowing the nerve to recover from stimulation.
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公开(公告)号：US20220401734A1
公开(公告)日：2022-12-22
申请号：US17872319
申请日：2022-07-25
发明人： Matteo Donega , Daniel John Chew , Isha Gupta
摘要： Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.
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