公开(公告)号：US20210189004A1

公开(公告)日：2021-06-24

申请号：US17196457

申请日：2021-03-09

Applicant: Genentech, Inc.

Inventor： Jeong KIM ,  Jeanne CHEUNG

IPC: C07K16/32 ,  A61K31/337 ,  C07K16/28 ,  A61K45/06 ,  A61K47/64 ,  A61K39/395 ,  A61K31/282 ,  C07K16/30

Abstract: The invention provides methods and compositions for treating cancer and for enhancing immune function in an individual having cancer. The methods comprise administering a PD-1 axis binding antagonist and a taxane.

公开(公告)号：US20200055939A1

公开(公告)日：2020-02-20

申请号：US16345619

申请日：2017-10-27

Applicant: Genentech, Inc.

Inventor： Twyla Noelle LOMBANA ,  Christoph SPIESS ,  Jeong KIM ,  Evangeline TOY ,  Jill SCHARTNER ,  Zhengmao YE ,  Jack BEVERS, III ,  Ryan COOK ,  Marissa MATSUMOTO ,  Amy BERKLEY

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00

Abstract: The invention provides anti-MIC antibodies and methods of using the same.

公开(公告)号：US20180303936A1

公开(公告)日：2018-10-25

申请号：US15886454

申请日：2018-02-01

Applicant: Genentech, Inc.

Inventor： Jeanne CHEUNG ,  Jeong KIM

IPC: A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  A61K38/16 ,  A61K39/00

CPC classification number: A61K39/39558 ,  A61K38/16 ,  A61K45/06 ,  A61K2039/507 ,  A61K2039/55 ,  C07K16/2827 ,  C07K16/2878 ,  C07K2317/75 ,  C07K2317/76

Abstract: The invention provides compositions and methods for treating cancers. The method comprises administering a PD-1 axis binding antagonist and an OX40 binding agonist.

公开(公告)号：US20180230227A1

公开(公告)日：2018-08-16

申请号：US15951082

申请日：2018-04-11

Applicant: Genentech, Inc.

Inventor： Changchun DU ,  Jeong KIM ,  Jing ZHU ,  Jack BEVERS, III ,  Kevin WALSH ,  Patricia DE ALMEIDA ,  James ANDYA ,  Ye SHEN

IPC: C07K16/28 ,  C07K16/30 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06 ,  C07K16/22

Abstract: The invention provides anti-OX40 antibodies and methods of using the same.

公开(公告)号：US20180057598A1

公开(公告)日：2018-03-01

申请号：US15669861

申请日：2017-08-04

Applicant: Genentech, Inc.

Inventor： Greg LAZAR ,  Yanli YANG ,  Erin H. CHRISTENSEN ,  Julie HANG ,  Jeong KIM ,  Seth HARRIS

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/2878 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2818 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/90 ,  C07K2317/92

Abstract: Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.

公开(公告)号：US20170290913A1

公开(公告)日：2017-10-12

申请号：US15625572

申请日：2017-06-16

Applicant: Genentech, Inc.

Inventor： Jeanne CHEUNG ,  Mahrukh HUSENI ,  Jeong KIM

IPC: A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  A61K38/16

CPC classification number: A61K39/39558 ,  A61K38/16 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/507 ,  A61K2039/55 ,  C07K16/2827 ,  C07K16/2878 ,  C07K2317/75 ,  C07K2317/76

Abstract: The invention provides compositions and methods for treating cancers. The method comprises administering a PD-1 axis binding antagonist and an OX40 binding agonist.

公开(公告)号：US20160355597A1

公开(公告)日：2016-12-08

申请号：US15176100

申请日：2016-06-07

Applicant: Genentech, Inc.

Inventor： Ina P. RHEE ,  Jeong KIM ,  Mahrukh HUSENI ,  Eric STEFANICH ,  Sid SUKUMARAN ,  Chi-Chung LI

IPC: C07K16/28 ,  A61K9/00

CPC classification number: C07K16/2878 ,  A61K9/0019 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/75 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

Abstract: The invention provides methods of treating or delaying progression of cancer in an individual comprising administering to the individual an anti-human OX40 agonist antibody. In some embodiments, the antibody is administered in a dose selected from about 0.2 mg, about 0.8 mg, about 3.2 mg, about 12 mg, about 40 mg, about 80 mg, about 130 mg, about 160 mg, about 300 mg, about 320 mg, about 400 mg, about 600 mg, and about 1200 mg.

Abstract translation: 本发明提供治疗或延缓个体中癌症进展的方法，包括向个体施用抗人OX40激动剂抗体。 在一些实施方案中，抗体以约0.2mg，约0.8mg，约3.2mg，约12mg，约40mg，约80mg，约130mg，约160mg，约300mg，约 320mg，约400mg，约600mg和约1200mg。