公开(公告)号：US20180230227A1

公开(公告)日：2018-08-16

申请号：US15951082

申请日：2018-04-11

Applicant: Genentech, Inc.

Inventor： Changchun DU ,  Jeong KIM ,  Jing ZHU ,  Jack BEVERS, III ,  Kevin WALSH ,  Patricia DE ALMEIDA ,  James ANDYA ,  Ye SHEN

IPC: C07K16/28 ,  C07K16/30 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06 ,  C07K16/22

Abstract: The invention provides anti-OX40 antibodies and methods of using the same.

公开(公告)号：US20210147562A1

公开(公告)日：2021-05-20

申请号：US17081784

申请日：2020-10-27

Applicant: Genentech, Inc.

Inventor： Gregory LAZAR ,  Jeong KIM ,  Jing ZHU ,  Yanli YANG ,  Randall BREZSKI

IPC: C07K16/28 ,  C07K16/32 ,  A61K47/68 ,  A61K38/02 ,  A61K39/395

Abstract: Provided herein are antigen binding polypeptides and complexes thereof having agonist activity. Also provided are methods for screening for complexes or polypeptides having agonist activity, enhancing the agonist activity of a polypeptide, and for agonizing a cell surface receptor using the complexes and polypeptide described herein.

公开(公告)号：US20210009705A1

公开(公告)日：2021-01-14

申请号：US16911229

申请日：2020-06-24

Applicant: Genentech, Inc.

Inventor： Changchun DU ,  Jeong KIM ,  Jing ZHU ,  Jack BEVERS, III ,  Kevin WALSH ,  Patricia DE ALMEIDA ,  James ANDYA ,  Ye SHEN

IPC: C07K16/28 ,  C07K16/22 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30

Abstract: The invention provides anti-OX40 antibodies and methods of using the same.

公开(公告)号：US20180022813A1

公开(公告)日：2018-01-25

申请号：US15725208

申请日：2017-10-04

Applicant: Genentech, Inc.

Inventor： Greg LAZAR ,  Jeong KIM ,  Jing ZHU ,  Yanli YANG ,  Randall BREZSKI

IPC: C07K16/28 ,  A61K39/395 ,  A61K38/02 ,  A61K47/68

CPC classification number: C07K16/2875 ,  A61K38/02 ,  A61K39/395 ,  A61K47/6881 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/2863 ,  C07K16/2878 ,  C07K16/32 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/622 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/92

Abstract: Provided herein are antigen binding polypeptides and complexes thereof having agonist activity. Also provided are methods for screening for complexes or polypeptides having agonist activity, enhancing the agonist activity of a polypeptide, and for agonizing a cell surface receptor using the complexes and polypeptide described herein.

公开(公告)号：US20170015755A1

公开(公告)日：2017-01-19

申请号：US15280586

申请日：2016-09-29

Applicant: Genentech, Inc.

Inventor： Kevin WALSH ,  Patricia DE ALMEIDA ,  Changchun DU ,  Jeong KIM ,  Jing ZHU ,  Jack BEVERS, III ,  James ANDYA ,  Ye SHEN

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/22

CPC classification number: C07K16/2878 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/22 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides compositions and methods for treating cancers. The method comprises administering an anti-angiogenesis agent and an OX40 binding agonist.

Abstract translation: 本发明提供了治疗癌症的组合物和方法。 该方法包括施用抗血管发生剂和OX40结合激动剂。