公开(公告)号：US20180057598A1

公开(公告)日：2018-03-01

申请号：US15669861

申请日：2017-08-04

Applicant: Genentech, Inc.

Inventor： Greg LAZAR ,  Yanli YANG ,  Erin H. CHRISTENSEN ,  Julie HANG ,  Jeong KIM ,  Seth HARRIS

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/2878 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2818 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/90 ,  C07K2317/92

Abstract: Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.

公开(公告)号：US20220064315A1

公开(公告)日：2022-03-03

申请号：US17322671

申请日：2021-05-17

Applicant: Genentech, Inc.

Inventor： Greg LAZAR ,  Yanli YANG ,  Erin H. CHRISTENSEN ,  Julie HANG ,  Jeong KIM ,  Seth HARRIS

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.

公开(公告)号：US20180022813A1

公开(公告)日：2018-01-25

申请号：US15725208

申请日：2017-10-04

Applicant: Genentech, Inc.

Inventor： Greg LAZAR ,  Jeong KIM ,  Jing ZHU ,  Yanli YANG ,  Randall BREZSKI

IPC: C07K16/28 ,  A61K39/395 ,  A61K38/02 ,  A61K47/68

CPC classification number: C07K16/2875 ,  A61K38/02 ,  A61K39/395 ,  A61K47/6881 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/2863 ,  C07K16/2878 ,  C07K16/32 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/622 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/92

Abstract: Provided herein are antigen binding polypeptides and complexes thereof having agonist activity. Also provided are methods for screening for complexes or polypeptides having agonist activity, enhancing the agonist activity of a polypeptide, and for agonizing a cell surface receptor using the complexes and polypeptide described herein.