公开(公告)号：US10781219B2

公开(公告)日：2020-09-22

申请号：US16441765

申请日：2019-06-14

Applicant: Genentech, Inc.

Inventor： Francis Gosselin ,  Chong Han ,  Theresa Cravillion ,  Sean M. Kelly ,  Scott Savage

IPC: C07D498/04

Abstract: Methods of making benzoxazepin oxazolidinone compounds as well as synthetic intermediates are described, including compound 18, having the structure:

公开(公告)号：US20180339997A1

公开(公告)日：2018-11-29

申请号：US15963876

申请日：2018-04-26

Applicant: Genentech, Inc.

Inventor： Paroma Chakravarty ,  Chong Han ,  Sean M. Kelly ,  Karthik Nagapudi ,  Scott Savage

IPC: C07D498/04 ,  A61P35/02 ,  A61P35/04

Abstract: The present invention relates to crystalline polymorph forms of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide (GDC-0077), having the structure, Formula I: or stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, and processes of preparing the polymorph forms.

公开(公告)号：US09975856B2

公开(公告)日：2018-05-22

申请号：US15287023

申请日：2016-10-06

Applicant: Genentech, Inc.

Inventor： Stephan Bachmann ,  Serena Maria Fantasia ,  Francis Gosselin ,  Chong Han ,  Stefan Hildbrand ,  Theresa Humphries ,  Christian Jenny ,  Ngiap-Kie Lim ,  Andrew McClory ,  Christian Moessner ,  Pankaj Rege ,  Scott Savage ,  Haiming Zhang

IPC: C07D231/56 ,  C07D405/04 ,  C07C309/73 ,  C07C69/73 ,  C07F5/04 ,  C07C69/612 ,  C07F5/02

CPC classification number: C07D231/56 ,  C07C69/612 ,  C07C69/73 ,  C07C69/738 ,  C07C309/73 ,  C07D405/04 ,  C07F5/025 ,  C07F5/04

Abstract: Processes are described for the preparation of estrogen receptor modulating compound, (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid I: and salts thereof, and intermediates useful for the preparation of I.

公开(公告)号：US09969735B2

公开(公告)日：2018-05-15

申请号：US15652776

申请日：2017-07-18

Applicant: Genentech, Inc.

Inventor： Ngiap-Kie Lim ,  Haiming Zhang ,  Chong Han

IPC: C07D471/14

CPC classification number: C07D471/14 ,  C07D471/04

Abstract: Processes are described for the preparation of tricyclic lactam compound of Formula (I), having the structure and intermediates useful for the preparation of (I).

公开(公告)号：US20150105557A1

公开(公告)日：2015-04-16

申请号：US14396346

申请日：2013-04-22

Applicant: Genentech, Inc.

Inventor： Chong Han

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The invention provides intermediates and processes of preparation thereof useful in the preparation of compounds that can be used as CHK1 inhibitors.

Abstract translation: 本发明提供了可用于制备可用作CHK1抑制剂的化合物的中间体及其制备方法。