Patent search cpc:"C07C309/73" Page 1

1.

发明申请
METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF OREXIN-2 RECEPTOR ANTAGONISTS 审中-公开

公开(公告)号：US20180044285A1

公开(公告)日：2018-02-15

申请号：US15791814

申请日：2017-10-24

Applicant: Eisai R&D Management Co., Ltd.

Inventor： George Anthony Moniz , Annie Zhu Wilcoxen , Farid Benayoud , Toshiaki Tanaka , Keiichi Sorimachi

IPC: C07C309/73 , C12P7/22 , C07C309/66 , C07C303/28 , C07C33/50 , C07D239/34 , C07D401/12 , C07C69/16 , C07C303/44 , C07C29/147

CPC classification number: C07C309/73 , C07B2200/07 , C07C29/147 , C07C69/16 , C07C303/28 , C07C303/44 , C07C309/66 , C07C2601/02 , C07D239/34 , C07D401/12 , C12P7/22 , C07C33/50

Abstract: The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.

2.

发明申请
1-(2-ACYLOXYETHYL)CYCLOPROPYL SULFONATE COMPOUND, 3-HALOMETHYL-3-BUTENYL CARBOXYLATE COMPOUND, AND METHOD FOR PRODUCING 4-ALKYL-3-METHYLENEBUTYL CARBOXYLATE 审中-公开

公开(公告)号：US20170158626A1

公开(公告)日：2017-06-08

申请号：US15436320

申请日：2017-02-17

Applicant: Shin-Etsu Chemical Co., Ltd.

Inventor： Takeshi Kinsho , Naoki Ishibashi , Yusuke Nagae

IPC: C07C309/66 , C07C309/73

CPC classification number: C07C309/66 , C07C67/287 , C07C67/293 , C07C67/297 , C07C69/63 , C07C69/65 , C07C309/73 , C07C315/04 , C07C317/04 , C07C317/14 , C07C2601/02 , C07C69/24 , C07C69/145

Abstract: Provided is a simple, selective and efficient method for producing 4-alkyl-3-methylenebutyl carboxylates such as 7-methyl-3-methylene-7-octenyl propionate. More specifically, provided is, for example, a method for producing a 4-alkyl-3-methylenebutyl carboxylate compound, comprising an acyloxylation step of subjecting a 1-(2-haloethyl)cyclopropyl sulfonate compound (1) to acyloxylation to obtain a 1-(2-acyloxyethyl)cyclopropyl sulfonate compound (2), a halogenation step of subjecting the compound (2) to halogenation involving cyclopropyl-allyl rearrangement to obtain a 3-halomethyl-3-butenyl carboxylate compound (3), and a coupling step of subjecting the compound (3) to a coupling reaction with an organometallic reagent (4) to obtain the 4-alkyl-3-methylenebutyl carboxylate compound (5).

3.

发明申请
PROCESS FOR THE PREPARATION OF (E)-3-(4-((E)-2-(2-CHLORO-4-FLUOROPHENYL)-1-(1H-INDAZOL-5-YL)BUT-1-EN-1-YL)PHENYL)ACRYLIC ACID 审中-公开

公开(公告)号：US20170101380A1

公开(公告)日：2017-04-13

申请号：US15287023

申请日：2016-10-06

Applicant: Genentech, Inc.

Inventor： Stephan Bachmann , Serena Maria Fantasia , Francis Gosselin , Chong Han , Stefan Hildbrand , Theresa Humphries , Christian Jenny , Ngiap-Kie Lim , Andrew McClory , Christian Moessner , Pankaj Rege , Scott Savage , Haiming Zhang

IPC: C07D231/56 , C07C309/73 , C07C69/73 , C07F5/04 , C07D405/04

CPC classification number: C07D231/56 , C07C69/612 , C07C69/73 , C07C69/738 , C07C309/73 , C07D405/04 , C07F5/025 , C07F5/04

Abstract: Processes are described for the preparation of estrogen receptor modulating compound, (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid I: and salts thereof, and intermediates useful for the preparation of I.

4.

发明授权
Sulfonium salt, resist composition and resist pattern forming process 有权

公开(公告)号：US09604921B2

公开(公告)日：2017-03-28

申请号：US14861303

申请日：2015-09-22

Applicant: SHIN-ETSU CHEMICAL CO., LTD.

Inventor： Daisuke Domon , Satoshi Watanabe , Keiichi Masunaga , Masahiro Fukushima

IPC: G03F7/039 , G03F1/76 , G03F7/20 , C07C305/24 , G03F7/004 , G03F7/038 , G03F7/32 , C07C381/12 , C07D327/08 , C07C309/42 , C07D333/76 , C07C309/73 , C07D335/12 , C07D335/16 , C07D339/08 , C07D493/08 , C07D279/20

CPC classification number: C07C305/24 , C07C309/42 , C07C309/73 , C07C381/12 , C07C2601/08 , C07C2601/14 , C07C2601/20 , C07C2603/74 , C07D279/20 , C07D327/08 , C07D333/76 , C07D335/12 , C07D335/16 , C07D339/08 , C07D493/08 , G03F1/76 , G03F1/78 , G03F7/0045 , G03F7/038 , G03F7/0382 , G03F7/039 , G03F7/0392 , G03F7/0395 , G03F7/0397 , G03F7/20 , G03F7/2004 , G03F7/2037 , G03F7/322

Abstract: A sulfonium salt of formula (0-1) is provided wherein W is alkylene or arylene, R01 is a monovalent hydrocarbon group, m is 0, 1 or 2, k is an integer: 0≦k≦5+4m, R101, R102 and R103 are a monovalent hydrocarbon group, or at least two of R101, R102 and R103 may bond together to form a ring with the sulfur atom, and L is a single bond, ester, sulfonic acid ester, carbonate or carbamate bond. A resist composition comprising the sulfonium salt as PAG exhibits a very high resolution when processed by EB and EUV lithography. A pattern with minimal LER is obtainable.

5.

发明申请
COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS 有权

公开(公告)号：US20160362362A1

公开(公告)日：2016-12-15

申请号：US15170848

申请日：2016-06-01

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Ajay Purohit , Pedro Benites , Edward H. Cheesman , Richard R. Cesati , Richard J. Looby , Heike S. Radeke

IPC: C07C303/30 , C07B59/00 , C07C277/08

CPC classification number: C07C303/30 , A61K51/00 , A61K51/04 , A61K51/0406 , C07B59/001 , C07B2200/05 , C07C53/06 , C07C53/10 , C07C53/18 , C07C63/08 , C07C213/02 , C07C217/58 , C07C255/54 , C07C277/00 , C07C277/08 , C07C279/10 , C07C279/24 , C07C303/28 , C07C309/04 , C07C309/30 , C07C309/65 , C07C309/66 , C07C309/73 , C07C279/08

Abstract: The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

6.

发明授权
Polymerizable composition comprising an oxime sulfonate as thermal curing agent 有权
Title translation: 包含肟磺酸盐作为热固化剂的可聚合组合物

公开(公告)号：US09310677B2

公开(公告)日：2016-04-12

申请号：US13981774

申请日：2012-01-27

Applicant: Kazuhiko Kunimoto , Kaori Sameshima , Yuki Matsuoka , Hisatoshi Kura

Inventor： Kazuhiko Kunimoto , Kaori Sameshima , Yuki Matsuoka , Hisatoshi Kura

IPC: G03F7/027 , G03F7/00 , G03F7/032 , G03F7/028 , G02B5/22 , C07D327/06 , C07C309/30 , C07C327/58 , C07D265/32 , C07D277/54 , C07D291/02 , C07D213/59 , C07C309/00 , C07C327/60 , C07D279/12 , C07D307/10 , C07D309/08 , G03F7/029 , G03F7/031 , G03F7/32 , G02B5/20

CPC classification number: G03F7/0007 , C07C309/00 , C07C309/30 , C07C309/67 , C07C309/73 , C07C327/58 , C07C327/60 , C07C2601/14 , C07C2602/42 , C07D213/59 , C07D213/78 , C07D265/32 , C07D277/54 , C07D279/12 , C07D291/02 , C07D295/04 , C07D307/10 , C07D309/08 , C07D327/06 , C08F220/10 , G02B5/201 , G02B5/223 , G03F7/027 , G03F7/028 , G03F7/029 , G03F7/031 , G03F7/032 , G03F7/322

Abstract: The present invention relates to a polymerizable composition comprising at least one ethylenically unsaturated, polymerizable compound and at least one oxime sulfonate compound of the formula (I) QAaBbCc where a is 0, 1, 2, 3, 4 or 6, b is 0, 1, 2, 3, 4 or 6, and c is 0, 1, 2, 3, 4 or 6, where the sum of a+b+c is 1, 2, 3, 4 or 6 where (A) is a group (B) is a group (C) is a group where # denotes the point of attachment to Q; X is S or NR14 and Q, R1, R2, R3 and R14 are as defined in claim 1 and in the description. The present invention also relates to the use of the this composition, to novel oxime sulfonates and the use of the oxime sulfonates as thermal curing promoter.

Abstract translation: 本发明涉及包含至少一种烯属不饱和的可聚合化合物和至少一种式（I）QAaBbCc的肟磺酸酯化合物的可聚合组合物，其中a是0,1,2,3,4或6，b是0， 1，2，3，4或6，c为0,1,2,3,4或6，其中a + b + c的和为1,2,3,4或6，其中（A）为组（B）是组（C）是其中＃表示与Q的连接点的组; X是S或NR14，Q，R1，R2，R3和R14如权利要求1和说明书中所定义。本发明还涉及该组合物用于制备新型肟磺酸盐和使用肟磺酸盐作为热固化促进剂的用途。

7.

发明授权
Process simplification for precursor compound 有权
Title translation: 前体化合物的工艺简化

公开(公告)号：US09238596B2

公开(公告)日：2016-01-19

申请号：US13994781

申请日：2011-12-19

Applicant: Tom Christian Berg

Inventor： Tom Christian Berg

IPC: C07C227/20 , C07C269/06 , C07C303/28 , C07C227/18 , C07B59/00

CPC classification number: C07B59/001 , C07B2200/05 , C07C227/18 , C07C227/20 , C07C269/06 , C07C303/28 , C07C2601/04 , Y02P20/55 , C07C271/24 , C07C309/65 , C07C309/73 , C07C229/48

Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET tracer.

Abstract translation: 本发明涉及一种制备放射性药物前体的方法，特别是用作生产用于体内成像方法如正电子发射断层摄影（PET）的放射性标记氨基酸的前体的保护的氨基酸衍生物。特别地，本发明涉及制备可用于制备[18 F] -1-氨基-3-氟环丁烷羧酸（[18 F] FACBC））PET示踪剂的前体的方法。

8.

发明授权
Synthesis of lactam based ionic liquid 有权
Title translation: 内酰胺类离子液体的合成

公开(公告)号：US09233928B2

公开(公告)日：2016-01-12

申请号：US14271308

申请日：2014-05-06

Applicant: UOP LLC

Inventor： Erin M. Broderick , Alakananda Bhattacharyya , Alan B. Levy , Lihao Tang

IPC: C07D223/10

CPC classification number: C07D223/10 , C07C309/73

Abstract: Lactamium based ionic liquids are described. They comprise at least one of: the reaction product of a lactam compound having a general formula wherein n is 1 to 8, and a Brønsted acid HX; or a Brønsted acid HX, where X is a halide, and a metal halide; where the reaction product is p-toluenesulfonate, halide, or the halometallate; or the reaction product of a lactam compound having a general formula wherein the ring has at least C—C one double bond, and n is 1 to 8, and a Brønsted acid HX; or a Brønsted acid HX, where X is a halide, and a metal halide; or the reaction product of a lactam compound having a general formula wherein n is 1 to 8, m is 1 to 8, and the rings can be saturated or unsaturated; and a Brønsted acid HX; or a Brønsted acid HX, where X is a halide, and a metal halide.

Abstract translation: 描述了基于乳酸的离子液体。它们包括以下中的至少一种：具有通式其中n为1至8的内酰胺化合物与布朗斯台德酸HX的反应产物; 或布朗斯台德酸HX，其中X为卤化物，和金属卤化物; 其中反应产物是对甲苯磺酸盐，卤化物或卤代金属盐; 或具有通式的内酰胺化合物的反应产物，其中环具有至少C-C一个双键，n为1至8，Brnnsted酸HX; 或布朗斯台德酸HX，其中X为卤化物，和金属卤化物; 或其中n为1〜8，m为1〜8的通式的内酰胺化合物的反应产物，并且所述环可以是饱和或不饱和的; 和布朗斯台德酸HX; 或布朗斯台德酸HX，其中X为卤化物，和金属卤化物。