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公开(公告)号：US09598376B2
公开(公告)日：2017-03-21
申请号：US15053441
申请日：2016-02-25
Applicant: Novartis AG , Array BioPharma, Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: C07D235/08 , C07D235/06 , A61K47/26 , A61K47/38 , A61K9/20 , C30B7/08 , C30B29/54 , A61K47/02 , A61K47/12
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro -3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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Patent Agency Ranking
公开(公告)号：US09382212B1
公开(公告)日：2016-07-05
申请号：US14974588
申请日：2015-12-18
Applicant: Novartis AG , Array BioPharma, Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: C07D235/06 , C30B7/08 , C30B29/54
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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23.发明申请公开(公告)号：US20160002210A1
公开(公告)日：2016-01-07
申请号：US14770035
申请日：2014-02-27
Applicant: ARRAY BIOPHARMA INC.
Inventor： Todd C. Eary , Bruno P. Hache , Derrick Juengst , Stacey Renee Spencer , Peter J. Stengel , Daniel John Watson
IPC: C07D403/12 , C07D231/56
CPC classification number: C07D403/12 , C07D231/56
Abstract: Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein.
Abstract translation: 本文提供了制备式（I）化合物以在合成吲唑衍生物的新方法中使用所述化合物作为中间体的新方法，以及通过本文所述的方法制备的吲唑中间体和衍生物。
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公开(公告)号：US10398683B2
公开(公告)日：2019-09-03
申请号：US15842715
申请日：2017-12-14
Applicant: Array BioPharma Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: A61K31/4184 , A61K45/06 , A61K47/26 , A61K9/20 , C07D235/08 , C07D235/06 , A61K47/12 , A61K47/02 , C30B29/54 , C30B7/08 , A61K47/38 , A61K9/00
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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公开(公告)号：US09980944B2
公开(公告)日：2018-05-29
申请号：US15445393
申请日：2017-02-28
Applicant: Array BioPharma, Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: A61K31/4184 , A61K9/00 , A61K9/20 , A61K45/06
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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公开(公告)号：US20160168103A1
公开(公告)日：2016-06-16
申请号：US14974655
申请日：2015-12-18
Applicant: Array BioPharma, Inc. , Novartis Pharma AG
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: C07D235/06 , A61K47/12 , A61K47/02 , A61K47/26 , A61K47/38
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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