公开(公告)号：US20050143455A1

公开(公告)日：2005-06-30

申请号：US11011433

申请日：2004-12-14

申请人： Bernhard Keppler

发明人： Bernhard Keppler

IPC分类号： A61K31/282 ,  A61P35/00 ,  C07C55/07 ,  C07C211/36 ,  C07F9/00 ,  C07F15/00 ,  A61K31/28

CPC分类号： C07F9/005

摘要： A tumor-inhibiting platinum (II) oxalate complex and its use as a therapeutic agent are provided, in particular as a tumor-inhibiting medicament. The complex may be compounds of the general formula (I), wherein the substituents R1, R1′, R2, R2′, R3, R3′, R4, and R4′ are independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted aryl and unsubstituted or substituted alkylaryl radicals, the substituents R5, R5′, R6, and R6′ are independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, and unsubstituted or substituted alkenyl radicals, and wherein optionally in each case at least two of the substituents R1, R1′, R2, R2′, R3, R3′, R4, and R4′ can form with one another at least one unsubstituted or substituted alkylene, unsubstituted or substituted alkenylene radical or an unsubstituted or substituted aromatic ring, and wherein optionally at least one of the carbon atoms of the cyclohexane ring bearing the substituents R1, R1′, R2, R2′, R3, R3′, R4, and R4′ is replaced by a heteroatom, and if the heteroatom is oxygen, the substituents R1, R1′, R2, R2′, R3, R3′, R4, and R4′ can additionally be hydroxy radicals, and pharmaceutically compatible salts of them, provided that at least one of the substituents R1, R1′, R2, R2′, R3, R3′, R4, or R4′ is not equal to hydrogen and the substituents R1 or R1′ and R4 or R4′ do not form any unsubstituted C1-2-alkylene radical with one another.

公开(公告)号：US20050032801A1

公开(公告)日：2005-02-10

申请号：US10627519

申请日：2003-07-25

申请人： Bernhard Keppler

发明人： Bernhard Keppler

IPC分类号： C07D231/56 ,  A61K9/08 ,  A61K31/416 ,  A61K33/24 ,  A61K45/06 ,  A61K47/02 ,  A61P35/00 ,  A61P35/04 ,  C07F15/00 ,  A61K31/50 ,  A61K31/4965 ,  A61K31/505

CPC分类号： C07F15/0053 ,  A61K31/28 ,  A61K31/415 ,  A61K31/416 ,  A61K33/00 ,  A61K33/02 ,  A61K33/14 ,  A61K33/24 ,  A61K45/06 ,  C07D231/56 ,  A61K2300/00

摘要： Compositions, containing a ruthenium(III) complex and a heterocycle, methods for their manufacture, medicament containing these compositions and a kit. The invention relates to a composition (A), obtained by reacting a compound of the general formula (I) M3−n−p−2pr[RuX6−n−p−q−2rBn(H2O)p(OH)q(O)r]2r+1  (I)with a compound of the general formula (II) B′(HX′)S  (II).Furthermore, the invention relates to a composition (B), obtained by mixing a compound of the general formula (III) (B′H)3−n−p−2pr[RuX6−n−p−q−2rBn(H2O)p(OH)q(O)r]2r+1  (III)with a compound of the general formula (IV) MX′  (IV).

摘要翻译： 包含钌（III）络合物和杂环的组合物，其制备方法，含有这些组合物的药物和试剂盒。 本发明涉及通过使通式（I）的化合物M3-np-2pr [RuX6-npq-2rBn（H2O）p（OH）q（O）r] 2r + 1（ I）与通式（II）B'（HX'）S（II）的化合物反应。 此外，本发明涉及通过将通式（III）的化合物（B'H）3-np-2pr [RuX6-npq-2rBn（H2O）p（OH）q（O） ）r] 2r + 1（III）与通式（IV）的化合物MX'（IV）反应。

公开(公告)号：US20050026896A1

公开(公告)日：2005-02-03

申请号：US10786924

申请日：2004-02-24

申请人： Bernhard Keppler

发明人： Bernhard Keppler

IPC分类号： A61P35/00 ,  C07F15/00 ,  A61K31/555 ,  A61K31/28

CPC分类号： C07F15/0093

摘要： Platinum(II) complexes are provided selected from the group consisting of compounds of the general formulae I to IV and physiologically acceptable addition salts thereof, wherein the radicals R1 to R4, R1′ to R3′, X, X′, Y, a, i, k and n are defined as in the description, and mixtures of the compounds for use as prophylactic and/or therapeutic agents for the treatment of diseases, and cytostatic platinum complexes with the general formulae [PtII(NH3)n(A)n(Z)2-n] or [PtIV(NH3)n(A)n(Z)2-nX2]and [PtII(A)1(Z)2] or [PtIV(A)1(Z)2X2]wherein A, Z and n are as defined in the description.

摘要翻译： 铂（II）络合物选自由通式I至IV的化合物及其生理上可接受的加成盐组成的组，其中基团R 1至R 4，R 1至R 3 '，X，X'，Y，a，i，k和n如描述中所定义，并且用作治疗疾病的预防和/或治疗剂的化合物和与 通式[Pt II（NH 3）n（A）n（Z）2-n]或[PtⅣ（NH 3）n（A）n（Z）2-nX 2]和[ A）1（Z）2]或[PtⅣ（A）1（Z）2X2]其中A，Z和n如说明书中所定义。