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25 条记录 (耗时 0.016 秒)

    Tumor-inhibiting anellated azepinone derivatives
    1.
    发明申请
    Tumor-inhibiting anellated azepinone derivatives 审中-公开
    抑制肿瘤的氮芥衍生物

    公开(公告)号：US20060009445A1

    公开(公告)日：2006-01-12

    申请号：US11165153

    申请日：2005-06-23

    申请人： Bernhard Keppler

    发明人： Bernhard Keppler

    IPC分类号： C07D487/02 ,  A61K31/55

    CPC分类号： C07D487/04 ,  C07F5/003

    摘要： This invention relates to anellated azepinone derivatives, a method of their production, metal complexes of the anellated azepinone derivatives as well as their use in the treatment of tumor diseases.

    摘要翻译： 本发明涉及茴香吖庚因衍生物，其制备方法，蒽醌衍生物的金属络合物及其在治疗肿瘤疾病中的用途。

    Cytostatic cerium compounds
    2.
    发明授权
    Cytostatic cerium compounds 失效
    细胞抑制性铈化合物

    公开(公告)号：US06921768B2

    公开(公告)日：2005-07-26

    申请号：US10773928

    申请日：2004-02-06

    申请人： Bernhard Keppler

    发明人： Bernhard Keppler

    IPC分类号： C07D213/22 ,  A61K33/24 ,  A61P35/00 ,  C07D471/04 ,  C07F5/00 ,  A61K31/444 ,  A61K31/4375 ,  C07D471/06

    CPC分类号： C07F5/003

    摘要： The invention relates to cerium compounds having general formulas (I) Rni+Yin− and (II) Rb+Yb+ and their application as medicaments in the prophylaxis and/or treatment of cancer diseases. In formula (I), R is a group of general formula (A): and in formula (II), Rb is a group of general formula (B)

    摘要翻译： 本发明涉及具有通式（I）的化合物：其中R 1和R 2各自独立地为氢， ）作为药物用于预防和/或治疗癌症疾病中的应用 。 式（I）中，R为通式（A）的基团：式（II）中，R b为通式（B）的基团，

    Medicament formulations containing ruthenium compounds with an antitumoral action
    4.
    发明授权
    Medicament formulations containing ruthenium compounds with an antitumoral action 失效
    含有具有抗肿瘤作用的钌化合物的药物制剂

    公开(公告)号：US4843069A

    公开(公告)日：1989-06-27

    申请号：US849455

    申请日：1986-04-25

    申请人： Heimo Keller ,  Bernhard Keppler

    发明人： Heimo Keller ,  Bernhard Keppler

    IPC分类号： C07F15/00 ,  A61K33/00 ,  A61K33/24 ,  A61P35/00

    CPC分类号： C07F15/0053

    摘要： A compound of the general formula I(BH.sub.n).sub.m [RuX.sub.3+nm-q-r.sup.(OH).sub.r (BH.sub.p).sub.3-nm+q ].sub.1+p+q IwhereinB denotes a mononuclear or polynuclear basic heterocyclic radical containing one or more nitrogen atoms,X denotes chlorine or bromine,m denotes 1 or 2,n denotes 1 or 2, the sum of n and m being not greater than 3,p denotes 0 or 1, but not 1 if n is 1,q denotes 0 or 1, but not 1 if p is 1 andr denotes 0 or 1,show an antitumoral activity and are therefore suitable as a chemotherapeutic for the treatment of cancers.

    摘要翻译： PCT No.PCT / EP85 / 00369 Sec。 371日期1986年3月21日 102（e）1986年3月21日PCT提交1985年7月24日PCT公布。 公开号WO86 / 00905 1986年2月13日。通式I（BHn）m [RuX 3 + nm-qr（OH）r（BHp）3-nm + q] 1 + p + q I的化合物，其中B表示单核或多核 含有一个或多个氮原子的碱性杂环基，X表示氯或溴，m表示1或2，n表示1或2，n和m的和不大于3，p表示0或1，但不是1，如果 n为1，q表示0或1，如果p为1且r表示0或1，则表示1，表示抗肿瘤活性，因此适合作为治疗癌症的化学治疗剂。

    Method to transmit physiological and biometric data of a living being
    7.
    发明申请
    Method to transmit physiological and biometric data of a living being 审中-公开
    传播生活的生理和生物特征数据的方法

    公开(公告)号：US20080045806A1

    公开(公告)日：2008-02-21

    申请号：US11732225

    申请日：2007-04-04

    申请人： Bernhard Keppler

    发明人： Bernhard Keppler

    IPC分类号： A61B5/117

    CPC分类号： A61B5/0002 ,  A61B5/1172 ,  G06K9/00006 ,  G06K9/00885 ,  G06K9/00906 ,  G06K2009/00939 ,  G07C9/00158 ,  G07C2009/00809

    摘要： There is disclosed a method comprising the steps of: 1. sensing biometric characteristic data of an individual; 2. comparing said biometric characteristic data to characteristic data of predetermined registered individuals and determining whether said individual is registered; 3. sensing physiological characteristic data of said individual; 4. comparing said physiological characteristic data with a predetermined range of acceptable values for said physiological characteristic data; and 5. sensing a parameter characteristic of a security condition; 6. comparing said parameter characteristic of a security condition with a predetermined range of acceptable values for said parameter 7. transmitting a signal if said individual is registered, if said physiological characteristic data is within said predetermined range or not and if said parameter characteristic of a security condition is within said range of acceptable values for said parameter.

    摘要翻译： 公开了一种方法，包括以下步骤：1.感测个体的生物特征数据; 2.将所述生物特征数据与预定注册个人的特征数据进行比较并确定所述个人是否被注册; 3.感测所述个人的生理特征数据; 4.将所述生理特征数据与所述生理特征数据的可接受值的预定范围进行比较; 和5.感测安全条件的参数特征; 6.如果所述生理特征数据在所述预定范围内，则所述生物特征数据是否在所述预定范围内，如果所述参数特性为 安全条件在所述参数的可接受值的所述范围内。

    ANTICANCER COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME
    8.
    发明申请
    ANTICANCER COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME 有权
    反应物组合物及其制备方法和使用方法

    公开(公告)号：US20070293557A1

    公开(公告)日：2007-12-20

    申请号：US11696116

    申请日：2007-04-03

    申请人： Bernhard Keppler

    发明人： Bernhard Keppler

    IPC分类号： A61K31/415 ,  A61K31/28 ,  A61P35/00 ,  C07D231/00 ,  C07F15/00

    CPC分类号： C07F15/0053 ,  A61K31/28 ,  A61K31/415 ,  A61K31/416 ,  A61K33/00 ,  A61K33/02 ,  A61K33/14 ,  A61K33/24 ,  A61K45/06 ,  C07D231/56 ,  A61K2300/00

    摘要： Compositions, containing a ruthenium(III) complex and a heterocycle, methods for their manufacture, medicament containing these compositions and a kit. The invention relates to a composition (A), obtained by reacting a compound of the general formula (I) M3−n−p−2pr[RUX6−n−p−q−2rBn(H2O)p(OH)q(O)r]2r+1  (I) with a compound of the general formula (II) B′(HX′)s  (II). Furthermore, the invention relates to a composition (B), obtained by mixing a compound of the general formula (III) (B′H)3−n−p−2pr[RUX6−n−p−q−2rBn(H2O)p(OH)q(O)r]2r+1  (III) with a compound of the general formula (IV) MX′  (IV).

    摘要翻译： 包含钌（III）络合物和杂环的组合物，其制备方法，含有这些组合物的药物和试剂盒。 本发明涉及通过使通式（I）的化合物<？in-line-formula description =“In-Line Formulas”end =“lead”→> np-2pr [RUX 6-npq-2r] N（H 2 O）p N （OH）q（O）R 2] 2r + 1（I）<？在线公式描述=“在线公式 “end =”tail“？>与通式（II）的化合物<？in-line-formula description =”In-line Formulas“end =”lead“？> B'（HX'） （II）。 另外，本发明涉及通过将通式（III）的化合物＆lt;＆lt;＆lt;＆lt; line-formula description =“In-line Formulas”end =“lead”？>（B'H）3-np-2pr （III）<β在线式描述=“In-line formula”end =“tail” line-formula description =“In-line Formulas”end =“lead”？> MX'（IV）。 <？in-line-formula description =“In-line Formulas”end =“tail”？>

    ANTICANCER COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME
    9.
    发明申请
    ANTICANCER COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME 有权
    反应物组合物及其制备方法和使用方法

    公开(公告)号：US20070293468A1

    公开(公告)日：2007-12-20

    申请号：US11696114

    申请日：2007-04-03

    申请人： Bernhard Keppler

    发明人： Bernhard Keppler

    IPC分类号： A61K31/555 ,  A61P35/00 ,  C07F15/00

    CPC分类号： C07F15/0053 ,  A61K31/28 ,  A61K31/415 ,  A61K31/416 ,  A61K33/00 ,  A61K33/02 ,  A61K33/14 ,  A61K33/24 ,  A61K45/06 ,  C07D231/56 ,  A61K2300/00

    摘要： Compositions, containing a ruthenium(III) complex and a heterocycle, methods for their manufacture, medicament containing these compositions and a kit. The invention relates to a composition (A), obtained by reacting a compound of the general formula (I) M3-n-p-2pr[RuX6-n-p-q-2rBn(H2O)p(OH)q(O)r]2r+1   (I) with a compound of the general formula (II) B′(HX′)S   (II). Furthermore, the invention relates to a composition (B), obtained by mixing a compound of the general formula (III) (B′H)3-n-p-2pr[RuX6-n-p-q-2rBn(H2O)p(OH)q(O)r]2r+1   (III) with a compound of the general formula (IV) MX′  (IV).

    摘要翻译： 包含钌（III）络合物和杂环的组合物，其制备方法，含有这些组合物的药物和试剂盒。 本发明涉及通过使通式（I）的化合物<？in-line-formula description =“In-Line Formulas”end =“lead”→> np-2pr [RuX 6-npq-2r] B n（H 2 O）p（n） （OH）q（O）R 2] 2r + 1（I）<？在线公式描述=“在线公式 “end =”tail“？>与通式（II）的化合物<？in-line-formula description =”In-line Formulas“end =”lead“？> B'（HX'） （II）。 另外，本发明涉及通过将通式（III）的化合物＆lt;＆lt;＆lt;＆lt; line-formula description =“In-line Formulas”end =“lead”？>（B'H）3-np-2pr （III）<β在线式描述=“In-line formula”end =“tail” line-formula description =“In-line Formulas”end =“lead”？> MX'（IV）。<？in-line-formula description =“In-line Formulas”end =“tail”？>

    Tumor-inhibiting platinum (II) oxalate complexes
    10.
    发明授权
    Tumor-inhibiting platinum (II) oxalate complexes 失效

    公开(公告)号：US07057059B2

    公开(公告)日：2006-06-06

    申请号：US11011433

    申请日：2004-12-14

    申请人： Bernhard Keppler

    发明人： Bernhard Keppler

    IPC分类号： C07F15/00 ,  A61K31/28

    CPC分类号： C07F9/005

    摘要： A tumor-inhibiting platinum (II) oxalate complex and its use as a therapeutic agent are provided, in particular as a tumor-inhibiting medicament. The complex may be compounds of the general formula (I), wherein the substituents R1, R1′, R2, R2′, R3, R3′, R4, and R4′ are independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted aryl and unsubstituted or substituted alkylaryl radicals, the substituents R5, R5′, R6, and R6′ are independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, and unsubstituted or substituted alkenyl radicals, and wherein optionally in each case at least two of the substituents R1, R1′, R2, R2′, R3, R3′, R4, and R4′ can form with one another at least one unsubstituted or substituted alkylene, unsubstituted or substituted alkenylene radical or an unsubstituted or substituted aromatic ring, and wherein optionally at least one of the carbon atoms of the cyclohexane ring bearing the substituents R1, R1′, R2, R2′, R3, R3′, R4, and R4′ is replaced by a heteroatom, and if the heteroatom is oxygen, the substituents R1, R1′, R2, R2′, R3, R3′, R4, and R4′ can additionally be hydroxy radicals, and pharmaceutically compatible salts of them, provided that at least one of the substituents R1, R1′, R2, R2′, R3, R3′, R4, or R4′ is not equal to hydrogen and the substituents R1 or R1′ and R4 or R4′ do not form any unsubstituted C1-2-alkylene radical with one another.