公开(公告)号：US20240293352A1

公开(公告)日：2024-09-05

申请号：US18288617

申请日：2022-05-06

申请人： Ottawa Hospital Research Institute ,  Colorado State University Research Foundation

发明人： Jean-Simon Diallo ,  Debbie C. Crans ,  Rozanne Arulanandam

IPC分类号： A61K31/28 ,  A61K33/42 ,  A61K35/766 ,  A61K35/768 ,  A61P35/00

CPC分类号： A61K31/28 ,  A61K33/42 ,  A61K35/766 ,  A61K35/768 ,  A61P35/00

摘要： The present application relates to vanadium compounds. More specifically, the present application relates to pharmaceutical compositions comprising vanadium salts, use thereof and methods using the same. The present application also includes compositions comprising vanadium compounds and a therapeutic or prophylactic virus providing for increased virus infection, spread, titer, activity, cytotoxicity and/or immunotherapeutic activity.

公开(公告)号：US12070511B2

公开(公告)日：2024-08-27

申请号：US17851454

申请日：2022-06-28

申请人： GE HEALTHCARE AS

发明人： Mikkel Jacob Thaning ,  Andreas Richard Meijer

IPC分类号： A61K49/10 ,  A61K9/00 ,  A61K31/28 ,  C07D257/00

CPC分类号： A61K49/108 ,  A61K9/0019 ,  A61K31/28 ,  A61K49/106 ,  C07D257/00

摘要： The present invention relates to a method of removal of metal ion impurities, such as calcium, from lanthanide metal complexes of macrocyclic chelators. The method uses a scavenger resin to remove metal ions, displaced from chelator, by an excess of lanthanide ions. Also provided is a method of preparation of MRI contrast agents, from the purified lanthanide metal complex, by the addition of a defined excess chelator.

公开(公告)号：US11969477B2

公开(公告)日：2024-04-30

申请号：US17809554

申请日：2022-06-28

申请人： Shenzhen Profound-View Pharma Tech Co., Ltd

发明人： Taolei Sun

IPC分类号： A61P27/02 ,  A61K31/28 ,  A61K33/242 ,  A61K47/54 ,  A61K47/64 ,  A61K47/69 ,  A61P27/06

CPC分类号： A61K47/6929 ,  A61K31/28 ,  A61K33/242 ,  A61K47/54 ,  A61K47/542 ,  A61K47/64 ,  A61K47/69 ,  A61P27/02 ,  A61P27/06

摘要： Disclosed is the use of a gold cluster or a gold cluster-containing substance in the preparation of a drug for preventing and/or treating glaucoma.

公开(公告)号：US20230165838A1

公开(公告)日：2023-06-01

申请号：US17921897

申请日：2021-05-03

申请人： DIMERIX BIOSCIENCE LTD.

发明人： Nina Webster ,  Robert Pearson Shepherd

IPC分类号： A61K31/4184 ,  A61K31/28 ,  A61P11/00

CPC分类号： A61K31/4184 ,  A61K31/28 ,  A61P11/00

摘要： A method for the treatment or amelioration of Acute Respiratory Distress Syndrome (ARDS) comprising the steps of administering to a subject a therapeutically effective amount of at least one chemokine receptor 2 (CCR2) pathway inhibitor or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20180338988A1

公开(公告)日：2018-11-29

申请号：US16025461

申请日：2018-07-02

申请人： PHARNEXT

发明人： Daniel Cohen ,  Ilya Chumakov ,  Serguei Nabirochkin ,  Emmanuel Vial ,  Mickael Guedj

IPC分类号： A61K31/585 ,  A61K45/06 ,  A61K31/137 ,  A61K31/64 ,  A61K31/50 ,  A61K31/4985 ,  A61K31/496 ,  A61K31/495 ,  A61K31/48 ,  A61K31/4709 ,  A61K31/445 ,  A61K31/44 ,  A61K31/423 ,  A61K31/42 ,  A61K31/4164 ,  A61K31/28 ,  A61K31/197 ,  A61K31/185 ,  A61K31/167 ,  A61K31/155 ,  A61K31/138

CPC分类号： A61K31/585 ,  A61K31/137 ,  A61K31/138 ,  A61K31/155 ,  A61K31/167 ,  A61K31/185 ,  A61K31/197 ,  A61K31/28 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/423 ,  A61K31/44 ,  A61K31/445 ,  A61K31/4709 ,  A61K31/48 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/50 ,  A61K31/64 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.

公开(公告)号：US20180251477A1

公开(公告)日：2018-09-06

申请号：US15972723

申请日：2018-05-07

申请人： King Fahd University of Petroleum and Minerals

发明人： Anvarhusein A. Isab ,  Muhammad Altaf

IPC分类号： C07F1/00 ,  A61K31/28 ,  A61K45/06 ,  A61K9/00

CPC分类号： C07F1/005 ,  A61K9/0053 ,  A61K31/28 ,  A61K45/06 ,  A61K47/50 ,  A61P35/00

摘要： A method for treating a proliferative disease, disorder, or condition comprising administering a gold(III) complex such as [Au(npen)Cl2]Cl.2H2O (1) or [Au(npen)2]Cl3 (2); the complexes, and methods for making them.

公开(公告)号：US10058569B2

公开(公告)日：2018-08-28

申请号：US15191025

申请日：2016-06-23

申请人： LUPIN LIMITED

发明人： Makarand Krishnakumar Avachat ,  Nikhil P. Malewar ,  Anirudha B. Kute ,  Girish Purushottam Bang

IPC分类号： A61K33/24 ,  A61K9/00 ,  A61K9/16

CPC分类号： A61K33/24 ,  A61K9/0053 ,  A61K9/1623 ,  A61K31/28

摘要： The invention relates to stable oral pharmaceutical compositions comprising lanthanum carbonate compounds and pharmaceutically acceptable excipients. The compositions of the present invention are formulated without the use of flow aids or lubricants. The compositions of the present invention have physical properties & flowability indicators comparable to that of the powders containing flow aids or lubricants and these compositions can be filled in sachets without any difficulty.

公开(公告)号：US20180209984A1

公开(公告)日：2018-07-26

申请号：US15742454

申请日：2016-07-07

申请人： ACCELERATED MEDICAL DIAGNOSTICS, INC. ,  LAWRENCE LIVERMORE NATIONAL SECURITY, LLC ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Paul Henderson ,  George D. Cimino ,  Chong-Xian Pan ,  Ralph William de Vere White ,  Maike Zimmermann ,  Kenneth W. Turteltaub

IPC分类号： G01N33/574 ,  A61K31/28 ,  A61K31/395 ,  G01N33/96 ,  G01N33/53 ,  G01N33/68 ,  G01N33/60

CPC分类号： G01N33/57484 ,  A61K31/28 ,  A61K31/395 ,  A61K31/555 ,  A61K31/7068 ,  A61K33/24 ,  A61K2300/00 ,  G01N33/5308 ,  G01N33/60 ,  G01N33/6848 ,  G01N33/96 ,  G01N2800/52 ,  G01N2800/56

摘要： The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.

公开(公告)号：US20180177826A1

公开(公告)日：2018-06-28

申请号：US15576062

申请日：2016-05-20

申请人： Arizona Board of Regents on Behalf of the University of Arizona

发明人： Vance G. NIELSEN ,  Leslie V. BOYER

IPC分类号： A61K33/26 ,  A61K33/24 ,  A61P39/02 ,  A61K45/06

CPC分类号： A61K33/26 ,  A61K31/28 ,  A61K31/295 ,  A61K31/69 ,  A61K33/24 ,  A61K45/06 ,  A61P39/02

摘要： This invention relates to compositions and methods for treating, ameliorating and preventing the toxic effects of venom poisoning. In particular, the invention provides compositions comprising carbon monoxide releasing molecules (CORM) or compositions comprising CORM and iron releasing molecules (IRM) for one or more of enhancing coagulation, reducing fibrinolysis, and/or inactivating venom related metalloproteinase activity in a subject suffering from or at risk of suffering from venom poisoning.

公开(公告)号：US20180169062A1

公开(公告)日：2018-06-21

申请号：US15576939

申请日：2016-05-26

申请人： Garnett McKeen Laboratory

发明人： Merrill Garnett

IPC分类号： A61K31/381 ,  A61K33/24 ,  A61P35/00 ,  A61K9/00 ,  A61N5/10

CPC分类号： A61K31/381 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/198 ,  A61K31/28 ,  A61K31/385 ,  A61K33/24 ,  A61N5/10 ,  A61N2005/1098 ,  A61P35/00 ,  A61K2300/00

摘要： The present invention provides a method for enhancing the anti-tumor effects of radiation therapy in a subject in need thereof. The method includes administering an effective amount of a composition comprising a palladium lipoic acid complex prior to, or along with, radiation therapy.