公开(公告)号：US4983633A

公开(公告)日：1991-01-08

申请号：US241028

申请日：1988-09-02

申请人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

发明人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

IPC分类号： A61K31/165 ,  C07C233/12 ,  C07C233/73 ,  C07C235/48 ,  C07C311/15 ,  C07D295/08 ,  C07D295/092 ,  C07D317/68

CPC分类号： C07D295/088 ,  C07C255/00 ,  C07D317/68

摘要： Amide-compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino which can be substituted by lower alkyl, nitro, cyano, sulfamoyl which can be substituted by lower alkyl, R.sub.2 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino, nitro, wherein R.sub.1 and R.sub.2 can be combined to form methylenedioxy, R.sub.3 means hydrogen, lower alkyl, halogen, or amino, R.sub.4 and R.sub.5 may be the same or different and each represents lower alkyl or wherein R.sub.4 and R.sub.5 may be combined together with nitrogen to form 1-pyrrolidinyl or piperidino, and pharmacologically-acceptable acid-addition salts thereof, which exhibit excellent effects in the activation of gastric motor function, a process for preparation pharmaceutical compositons thereof, as well as a method for the treatment of a subject suffering from an ailment associated with inadequate gastric motor function by administrating such a compound to the said subject, are all disclosed.

公开(公告)号：US4943581A

公开(公告)日：1990-07-24

申请号：US371392

申请日：1989-06-26

申请人： Hiroyoshi Hidaka ,  Toshio Tanaka ,  Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Kazuya Mitani ,  Shunichiro Sakurai

发明人： Hiroyoshi Hidaka ,  Toshio Tanaka ,  Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Kazuya Mitani ,  Shunichiro Sakurai

IPC分类号： C07D217/02 ,  A61K31/47 ,  A61K31/472 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D217/04

CPC分类号： C07D217/04 ,  Y02P20/55

摘要： An isoquinolinesulfonamide selected from those represented by the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different, and each represent hydrogen or lower-alkyl, and X represents hydrogen or halogen, and pharmacologically-acceptable acid addition salts thereof, pharmaceutical compositions thereof, and use thereof in the treatment of circular disorders, are disclosed.

摘要翻译： 选自由下式表示的异喹啉磺酰胺：其中R 1，R 2和R 3可以相同或不同，并且各自表示氢或低级烷基，X表示氢或卤素，以及其药学上可接受的酸加成盐 ，其药物组合物及其在治疗循环障碍中的用途。

公开(公告)号：US4912116A

公开(公告)日：1990-03-27

申请号：US136912

申请日：1987-12-22

申请人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Kouji Morikawa ,  Toshie Yamauchi

发明人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Kouji Morikawa ,  Toshie Yamauchi

IPC分类号： C07D295/10 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/443 ,  A61K31/445 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P13/02 ,  A61P15/00 ,  C07D307/79 ,  C07D317/58 ,  C07D405/06

CPC分类号： A61K31/535 ,  A61K31/40 ,  A61K31/445 ,  A61K31/55 ,  Y10S514/906

摘要： A method for the treatment of pollakiurea in a subject in need thereof, comprising the step of administering to said subject an effective antipollakiurea amount of a propiophenone of the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each independently represents hydrogen, halogen, lower alkyl- or halogeno-lower-alkyl, lower-alkoxy, or cycloalkyl having 3-8 carbon atoms, two of which R.sub.1, R.sub.2, and R.sub.3 groups may combine to form methylenedioxy or ethyleneoxy, R.sub.4 represents hydrogen or a lower-alkyl, and A represents pyrrolidinyl-, piperidinyl-, morpholinyl-, or azepinyl or a pharmaceutically-acceptable acid addition salt thereof, is disclosed.

公开(公告)号：US4093630A

公开(公告)日：1978-06-06

申请号：US804591

申请日：1977-06-08

申请人： Hideo Kato ,  Tomoyasu Nishikawa ,  Eiichi Koshinaka

发明人： Hideo Kato ,  Tomoyasu Nishikawa ,  Eiichi Koshinaka

IPC分类号： A61K31/495 ,  A61K31/55 ,  A61P43/00 ,  C07D487/04 ,  C07D487/08

CPC分类号： C07D487/04

摘要： Novel diazabicycloalkane derivatives of the formula ##STR1## wherein R is hydrogen or a halogen including acid addition salts thereof are provided including a process for their preparation. These compounds are useful as antihistamines.

摘要翻译： 提供了式（I）的新型二氮杂双环烷烃衍生物，其中R是氢或包括其酸加成盐的卤素包括其制备方法。 这些化合物可用作抗组胺剂。