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120 条记录 (耗时 0.046 秒)

    BICYCLIC ANILIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS
    21.
    发明申请
    BICYCLIC ANILIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS 有权
    双相抗体异源CGRP受体拮抗剂

    公开(公告)号：US20100093759A1

    公开(公告)日：2010-04-15

    申请号：US12595874

    申请日：2008-04-11

    申请人： Ian M. Bell ,  Harold G. Selnick ,  Craig A. Stump

    发明人： Ian M. Bell ,  Harold G. Selnick ,  Craig A. Stump

    IPC分类号： A61K31/438 ,  C07D471/20 ,  A61K31/437 ,  A61K31/506 ,  A61P25/00

    CPC分类号： C07D471/20 ,  C07D519/00

    摘要： Compounds of formula I: I (wherein variables A1, A2, B, m, n, J, R4, G1, G2, G3 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译： 式I：I（其中变量A1，A2，B，m，n，J，R4，G1，G2，G3和Y如本文所述）是CGRP受体的拮抗剂，其可用于治疗或预防 涉及CGRP的疾病，如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    CGRP RECEPTOR ANTAGONISTS
    26.
    发明申请
    CGRP RECEPTOR ANTAGONISTS 有权
    CGRP受体拮抗剂

    公开(公告)号：US20110224201A1

    公开(公告)日：2011-09-15

    申请号：US13121784

    申请日：2009-09-29

    申请人： Donnette D. Staas ,  Ian M. Bell ,  Harold G. Selnick

    发明人： Donnette D. Staas ,  Ian M. Bell ,  Harold G. Selnick

    IPC分类号： A61K31/537 ,  C07D498/20 ,  C07D498/04 ,  A61P25/06 ,  A61P25/00

    CPC分类号： C07D498/20 ,  C07D498/04 ,  C07D498/10

    摘要： Compounds of Formula (I), (wherein variables A1, A2, A3, A4, A5, A6, A7, A8, L, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG, W, Y and Z are as described herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.

    摘要翻译： 式（I）化合物（其中变量A1，A2，A3，A4，A5，A6，A7，A8，L，J，Q，R4，Ea，Eb，Ec，R6，R7，Re，Rf， W，Y和Z如本文所述）可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP受体的疾病，例如头痛，特别是偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP受体的疾病中的用途。

    CGRP receptor antagonists
    27.
    发明授权
    CGRP receptor antagonists 有权
    CGRP受体拮抗剂

    公开(公告)号：US08685965B2

    公开(公告)日：2014-04-01

    申请号：US13121784

    申请日：2009-09-29

    申请人： Donnette D. Staas ,  Ian M. Bell ,  Harold G. Selnick

    发明人： Donnette D. Staas ,  Ian M. Bell ,  Harold G. Selnick

    IPC分类号： A61K31/537

    CPC分类号： C07D498/20 ,  C07D498/04 ,  C07D498/10

    摘要： Compounds of Formula (I), (wherein variables A1, A2, A3, A4, A5, A6, A7, A8, L, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG, W, Y and Z are as described herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.

    摘要翻译： 式（I）化合物（其中变量A1，A2，A3，A4，A5，A6，A7，A8，L，J，Q，R4，Ea，Eb，Ec，R6，R7，Re，Rf， W，Y和Z如本文所述）可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP受体的疾病，例如头痛，特别是偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP受体的疾病中的用途。

    CONSTRAINED SPIROCYCLIC COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS
    28.
    发明申请
    CONSTRAINED SPIROCYCLIC COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS 有权
    作为CGRP受体拮抗剂的约束螺旋化合物

    公开(公告)号：US20100069359A1

    公开(公告)日：2010-03-18

    申请号：US12517674

    申请日：2007-12-05

    申请人： Ian M. Bell ,  Harold G. Selnick

    发明人： Ian M. Bell ,  Harold G. Selnick

    IPC分类号： A61K31/55 ,  C07D487/00 ,  A61P43/00

    CPC分类号： C07D487/04

    摘要： Compounds of formula I: (wherein variables A1, A2, A3, G1, G2, G3, J, m, n, p, R1, R2, R3, R4 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译： 式I化合物（其中变量A1，A2，A3，G1，G2，G3，J，m，n，p，R1，R2，R3，R4和Y如本文所述），其是CGRP受体的拮抗剂， 可用于治疗或预防涉及CGRP的疾病，如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    BENZAZEPINE COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS
    29.
    发明申请
    BENZAZEPINE COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS 审中-公开
    苯并噻唑化合物作为CGRP受体拮抗剂

    公开(公告)号：US20120065190A1

    公开(公告)日：2012-03-15

    申请号：US12520146

    申请日：2007-12-14

    申请人： Ian M. Bell ,  Harold G. Selnick

    发明人： Ian M. Bell ,  Harold G. Selnick

    IPC分类号： A61K31/55 ,  C07D487/04 ,  A61P25/08 ,  A61P25/06 ,  A61P9/12 ,  C07D519/00 ,  A61P29/00

    CPC分类号： C07D487/04 ,  A61K31/55 ,  A61K45/06 ,  C07D471/10 ,  C07D471/20 ,  C07D498/20 ,  C07D519/00

    摘要： Compounds of formula I: (wherein variables A1, m, R1, R2, R3, R4 and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    摘要翻译： 式I化合物（其中变量A1，m，R1，R2，R3，R4和Z如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病， 如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。