公开(公告)号：US07465444B2

公开(公告)日：2008-12-16

申请号：US10472743

申请日：2002-02-18

申请人： Mamoru Watanabe

发明人： Mamoru Watanabe

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/28

CPC分类号： C07K16/2818 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/73

摘要： Antibodies against AILIM (also called ICOS and 8F4) were found to significantly suppress the onset of inflammatory bowel diseases (especially Crohn's disease and colitis (ulcerative colitis and such)), and exhibit a significant therapeutic effect against inflammatory bowel diseases.

摘要翻译： 发现针对AILIM（也称为ICOS和8F4）的抗体显着抑制炎症性肠病（特别是克罗恩病和结肠炎（溃疡性结肠炎等））的发病，并且对炎症性肠病具有显着的治疗作用。

公开(公告)号：US20080205199A1

公开(公告)日：2008-08-28

申请号：US12012832

申请日：2008-02-06

申请人： Mamoru Watanabe

发明人： Mamoru Watanabe

IPC分类号： G04B9/00 ,  G04B1/10

CPC分类号： G04B9/005

摘要： To provide a residual wound quantity display mechanism of a timepiece, in which it is possible to change a way of a display without changing a basic structure, and a timepiece with the mechanism concerned. A residual wound quantity display mechanism of a mechanical timepiece has an output gearwheel rotating in compliance with a change in a residual wound quantity of a mainspring; a drive lever possessing monolithically a fan-shaped gearwheel part meshing with the output gearwheel, and an arm part extending from a rotation center of the fan-shaped gearwheel part in a direction different from a fan-shaped portion of the fan-shaped gearwheel part; a display member possessing a drive gearwheel part rotatably supported to a tip part of the arm part of the drive lever, and a display arbor formed monolithically in the drive gearwheel part in a site separated from a rotation center of the drive gearwheel part; and a fixation gearwheel possessing a fixation tooth part with which a tooth part of the drive gearwheel part of the display member meshes. Typically the fixation gearwheel adopts a form of the internally-toothed gearwheel.

摘要翻译： 提供一种能够改变显示方式而不改变基本结构的钟表的剩余卷绕量显示机构以及具有该机构的钟表。 机械钟表的剩余卷绕量显示机构具有按照发条的剩余卷绕量的变化而旋转的输出齿轮; 具有与输出齿轮啮合的扇形齿轮部分的驱动杆，以及从扇形齿轮部分的旋转中心沿与扇形齿轮部分的扇形部分不同的方向延伸的臂部分 ; 具有可旋转地支撑在所述驱动杆的臂部的前端部的驱动齿轮部的显示部件和与所述驱动齿轮部的旋转中心分离的位置的所述驱动齿轮部中的整体地形成的显示轴; 以及具有固定齿部的固定齿轮，所述显示部件的驱动齿轮部的齿部与所述固定齿部啮合。 通常，固定齿轮采用内齿轮的形式。

公开(公告)号：US20070291593A1

公开(公告)日：2007-12-20

申请号：US11667176

申请日：2004-12-15

申请人： Takeshi Tokoro ,  Kei Hirano ,  Mamoru Watanabe

发明人： Takeshi Tokoro ,  Kei Hirano ,  Mamoru Watanabe

IPC分类号： G04B19/00 ,  G04B35/00

CPC分类号： G04B19/241 ,  G04B19/25

摘要： To realize a multifunctional watch which is constituted so as to be capable of forming a plurality of movement layouts without changing sizes and shapes of components for the movement only by changing positions where the components are incorporated. A movement 201 of a multifunctional watch is provided with a first train wheel rotational center and a second train wheel rotational center. The first train wheel rotational center and the second train wheel rotational center are aligned on a position between a main plate center 202c of a main plate 202 and a main plate outline portion of the main plate 202. On the first train wheel rotational center and the second train wheel rotational center, a train wheel guide portion for rotatably guiding a train wheel member is disposed, respectively. A train wheel for displaying time information or calendar information is aligned rotatably for on of the first train wheel rotational center and the second train wheel rotational center.

摘要翻译： 为了实现多功能手表，其被构造成能够形成多个运动布局，而不改变移动部件的尺寸和形状，仅通过改变其中结合的部件的位置。 多功能表的机芯201具有第一列车轮转动中心和第二列车轮转动中心。 第一列车轮旋转中心和第二列车轮旋转中心在主板202的主板中心202c与主板202的主板轮廓部分之间的位置对准。 在第一列车轮转动中心和第二列车轮转动中心，分别设置有用于可转动地引导轮系构件的轮系引导部。 用于显示时间信息或日历信息的列车轮可旋转地对准第一列车轮转动中心和第二列车轮转动中心。

公开(公告)号：US07269102B2

公开(公告)日：2007-09-11

申请号：US11297586

申请日：2005-12-08

申请人： Kei Hirano ,  Mamoru Watanabe ,  Takeshi Tokoro

发明人： Kei Hirano ,  Mamoru Watanabe ,  Takeshi Tokoro

IPC分类号： G04B19/24

CPC分类号： G04C17/00 ,  G04B19/24 ,  G04B19/241

摘要： To realize a small-sized analog multifunction timepiece by adopting a fan shape moving hand mechanism which does not use a hairspring. A multifunction timepiece of the invention is provided with a day display mechanism for operating a small hand moving in a fan shape. The day display mechanism is provided with a day indicator driving wheel, a day jumper, a small day wheel for displaying calendar information, a hammer constituted to rotate based on rotation of a day indicator transmission wheel, and a day return spring for exerting a rotational force to the small day wheel. By bringing a cam contact portion of the hammer to a transmission cam outer periphery portion and exerting an elastic force to a return cam outer shape portion by a return spring portion of the day return spring, the small day wheel is constituted to be exerted with a rotational force in a constant direction.

摘要翻译： 通过采用不使用游丝的扇形移动手机来实现小型模拟多功能手表。 本发明的多功能钟表设置有用于操作以扇形移动的小手的日显示机构。 日间显示机构设置有日指示器驱动轮，日间跳线，用于显示日历信息的小日轮，基于日指示器传动轮的旋转而构成的旋转锤和用于施加旋转的日复位弹簧 力量到小天轮。 通过将锤的凸轮接触部分通过变速器凸轮外周部分引导并通过日复位弹簧的复位弹簧部分向返回凸轮外形部分施加弹力，小型日轮被构造成施加有 恒定方向的旋转力。

公开(公告)号：US06755567B2

公开(公告)日：2004-06-29

申请号：US10339071

申请日：2003-01-09

申请人： Mamoru Watanabe ,  Yuichi Shino ,  Tamotsu Ono ,  Kei Hirano

发明人： Mamoru Watanabe ,  Yuichi Shino ,  Tamotsu Ono ,  Kei Hirano

IPC分类号： G04B500

CPC分类号： G04B35/00 ,  G04F7/0866

摘要： To provide a hand motion irregularity suppressed timepiece whose ability has been improved. As to a spring having a flat portion and a bent portion, the flat portion is disposed between a second chronograph wheel and a center wheel, and the bent portion is sandwiched and supported under a pressurized state by a train wheel bridge and a bottom plate. By this, the spring portion prevents a hand motion irregularity of the second chronograph wheel by the fact that the second chronograph wheel is pressure-contacted with the train wheel bridge. Further, by forming a gap between the second chronograph wheel and the center wheel, an accompanying rotation between the second center wheel and the center wheel is prevented.

摘要翻译： 提供能力提高的手动不规则抑制钟表。 对于具有平坦部分和弯曲部分的弹簧，平坦部分设置在第二计时轮和中心轮之间，并且弯曲部分通过轮系桥和底板在加压状态下被夹持和支撑。 由此，弹簧部分通过第二计时轮与轮系桥压力接触的事实来防止第二计时轮的手运动不规则。 此外，通过在第二计时轮和中心轮之间形成间隙，防止第二中心轮与中心轮之间的伴随旋转。

公开(公告)号：US06687191B2

公开(公告)日：2004-02-03

申请号：US09814519

申请日：2001-03-22

申请人： Mamoru Watanabe ,  Shigeo Suzuki ,  Kenichi Nakajima

发明人： Mamoru Watanabe ,  Shigeo Suzuki ,  Kenichi Nakajima

IPC分类号： G04B1924

CPC分类号： G04B19/25353

摘要： A calendar timepiece has a main plate having a guide portion and a date indicator driving wheel mounted on the main plate to undergo rotation. A date feed finger is connected to the date indicator driving wheel for rotation therewith to engage the guide portion of the main plate so that the date feed finger is displaced in a generally thickness direction of the main plate. A date indicator has a tooth portion for meshing engagement with the date feed finger when the date feed finger engages the guide portion of the main plate and is displaced in the thickness direction of the main plate so that the date indicator undergoes rotation relative to the main plate to indicate date information during rotation of the date feed finger. A day feed finger is connected to the date indicator driving wheel for rotation therewith. A day indicator is connected to the day feed finger for rotation therewith to indicate a day of the week.

摘要翻译： 日历表具有主板，其具有安装在主板上的引导部分和日期指示器驱动轮以进行旋转。 日期进给指状物连接到日期指示器驱动轮上以与其一起旋转，以与主板的引导部分接合，使得日期进给指在主板的大致厚度方向上移位。 日期指示器具有用于与日期进给手指啮合的齿部分，当日期进给手指接合主板的引导部分并且在主板的厚度方向上移位时，日期指示器相对于主体进行旋转 在日期进纸手指旋转期间指示日期信息。 日日期指针驱动轮连接到日期指示器驱动轮上以与之一起旋转。 日指示器连接到日饲料手指以与其一起旋转以指示一周中的某一天。

公开(公告)号：US06612734B1

公开(公告)日：2003-09-02

申请号：US09787854

申请日：2001-04-27

申请人： Mamoru Watanabe ,  Takeshi Tokoro

发明人： Mamoru Watanabe ,  Takeshi Tokoro

IPC分类号： G04B1500

CPC分类号： G04B17/32 ,  G04B17/34 ,  G04B18/023

摘要： A mechanical timepiece movement has a mainspring serving as a power source, a wheel train rotated by a rotational force produced by the mainspring for driving a display, and an escapement and speed control apparatus for controlling rotation of the wheel train and having a balance with hairspring, an escape wheel and pinion and a pallet fork. A stud holder is rotatably mounted with respect to a central axis of the balance with hairspring and a hairspring holder is attached to the stud holder to undergo movement in a direction orthogonal to the central axis of the balance with hairspring. A hairspring has a central portion fixed to the balance with hairspring and an outer portion fixed to the hairspring holder. The hairspring is adjustable by pivoting the hairspring holder.

摘要翻译： 机械钟表机构具有作为动力源的主发条，由用于驱动显示器的发条产生的旋转力旋转的轮系，以及用于控制轮系的旋转并具有游丝的平衡的擒纵机构和速度控制装置 ，擒纵轮和小齿轮以及托盘叉。 螺柱保持器相对于具有游丝的平衡体的中心轴线可旋转地安装，并且游丝保持器附接到螺柱保持器以在与游丝的平衡体的中心轴线正交的方向上运动。 游丝具有固定在游丝的平衡物上的中央部分和固定在游丝架上的外部部分。 游丝可以通过旋转游丝架来调节。

公开(公告)号：US06295249B1

公开(公告)日：2001-09-25

申请号：US09582016

申请日：2000-08-29

申请人： Masaaki Takahashi ,  Mamoru Watanabe

发明人： Masaaki Takahashi ,  Mamoru Watanabe

IPC分类号： G04B1920

CPC分类号： G04B27/06

摘要： A correction device for a timepiece comprises a setting wheel which has a rotational center and which is rotatably mountable to a movement of a timepiece for undergoing rotation in accordance with rotation of a winding stem. A rocking bar has a rotational center on an axis line coinciding with an axis line of the rotational center of the setting wheel and is mounted for undergoing rocking movement in a first rotational direction relative to the movement of the timepiece and undergoing rocking movement in a second rotational direction different from the first rotational direction. The rocking bar has a first portion extended in a first direction from the rotational center and a second portion extended in a second direction from the rotational center. At least one first correction transfer wheel is disposed at the first portion of the rocking bar for undergoing rotation in accordance with rotation of the setting wheel. At least one second correction transfer wheel is disposed at the second portion of the rocking bar for undergoing rotation in accordance with rotation of the setting wheel.

摘要翻译： 一种钟表的校正装置，包括具有旋转中心的调节轮，该调节轮可旋转地安装到根据上条杆的旋转进行旋转的钟表的运动。 摇杆具有与设置轮的旋转中心的轴线重合的轴线上的旋转中心，并且安装成相对于钟表的运动在第一旋转方向上进行摇摆运动，并且在第二旋转中进行摇摆运动 旋转方向与第一旋转方向不同。 摇杆具有从旋转中心沿第一方向延伸的第一部分和从旋转中心沿第二方向延伸的第二部分。 至少一个第一校正传递轮设置在摇杆的第一部分处，以根据调节轮的旋转进行旋转。 至少一个第二校正传递轮设置在摇杆的第二部分处，以根据调节轮的旋转进行旋转。

公开(公告)号：US5863514A

公开(公告)日：1999-01-26

申请号：US593810

申请日：1996-01-30

申请人： Takayoshi Sasaki ,  Mamoru Watanabe ,  Masayuki Tsutsumi

发明人： Takayoshi Sasaki ,  Mamoru Watanabe ,  Masayuki Tsutsumi

IPC分类号： A61K8/30 ,  A61K8/19 ,  A61K8/29 ,  A61Q1/02 ,  B01J21/06 ,  B01J35/02 ,  C01G23/04 ,  C01G23/047 ,  C01G23/053 ,  C09D7/12 ,  D21H19/38 ,  C01G23/46 ,  C01G23/47

CPC分类号： C01G23/047 ,  C01G23/053 ,  C01P2002/02 ,  C01P2004/03 ,  C01P2004/20 ,  C01P2004/50 ,  C01P2004/54 ,  C01P2006/12 ,  C01P2006/17

摘要： Titanium oxide, comprising lamina shaped titanium oxide particles having a thickness of 10-30 nm and a width of 0.5 to 1 .mu.m, may be prepared by exfoliating a layered titanic acid powder having a formula H.sub.x Ti.sub.2-x/4 O.sub.4.nH.sub.2 O, where x=0.60-0.75, to form a titania sol; followed by drying and heating, to obtain a titanium oxide. The layered titanic acid powder may be prepared by contacting cesium titanate having an orthorhombic layered structure with an aqueous acid solution.

摘要翻译： 包括厚度为10-30nm，宽度为0.5-1μm的层状氧化钛颗粒的氧化钛可以通过剥离具有式H x Ti 2-x / 4 O 4·nH 2 O的层状钛酸粉末来制备，其中x = 0.60-0.75，形成二氧化钛溶胶; 然后干燥和加热，得到氧化钛。 层状钛酸粉末可以通过使具有正交层状结构的钛酸铯与酸水溶液接触来制备。

公开(公告)号：US5479247A

公开(公告)日：1995-12-26

申请号：US238540

申请日：1994-05-05

申请人： Mamoru Watanabe ,  Michihiro Fujii

发明人： Mamoru Watanabe ,  Michihiro Fujii

IPC分类号： G03G21/10 ,  G03G15/08 ,  G03G21/00 ,  G03G15/06

CPC分类号： G03G15/0844 ,  G03G15/0868 ,  G03G2215/0665 ,  G03G2215/067 ,  G03G2215/0675 ,  G03G2215/0685

摘要： A developer cartridge designed to permit discrimination of whether the cartridge is used or unused, and an image forming apparatus using this cartridge. The developer cartridge includes a cylindrical body whose rotational axis extends in a direction perpendicular to a developer carrying direction of the developing unit; a first developer storage room, provided at the cylindrical body, for storing an unused developer; an opening formed in the first developer storage room; a case having a cylinder for rotatably retaining the cylindrical body, the cylinder having an injection port provided in association with the opening of the first developer storage room; a second developer storage room, provided at a lower portion of the cylinder of the case, for storing a used developer from the developing unit; and a setting device selectively movable to a first position indicating an unused share of the developer cartridge and a second position indicating a used state of the developer cartridge to detect if the developer cartridge is unused or used. The image forming apparatus includes an endless latent carrier; an apparatus for forming an electrostatic latent image on the endless latent carrier; developing means for developing the electrostatic latent image on the endless latent carrier; a developer cartridge detachably attached to the developing means for exchanging developers, and having the same components as the above-described cartridge; drive apparatus for driving the cylindrical body of the developer cartridge for developer exchange; a detecting unit for detecting the setting device of the developer cartridge to detect if the developer cartridge is unused or used; and a control circuit for controlling the drive apparatus in accordance with a detection result from the detecting unit.

摘要翻译： 一种设计用于允许辨别墨盒是否被使用或不使用的显影剂盒，以及使用该盒的图像形成装置。 显影剂盒包括圆柱体，其旋转轴线在垂直于显影单元的显影剂输送方向的方向上延伸; 设置在圆柱体上的第一显影剂储存室，用于存储未使用的显影剂; 在第一显影剂储藏室中形成的开口; 具有用于可旋转地保持所述圆柱体的圆筒的壳体，所述圆筒具有与所述第一显影剂储藏室的开口相关联地设置的注射口; 第二显影剂储藏室，设置在所述壳体的圆柱体的下部，用于从所述显影单元存储用过的显影剂; 以及设置装置，其选择性地可移动到指示显影剂盒的未使用份额的第一位置，以及指示显影剂盒的使用状态以检测显影剂盒未被使用或使用的第二位置。 图像形成装置包括无端潜载体; 用于在无端潜载体上形成静电潜像的装置; 显影装置，用于在无端潜载体上显影静电潜像; 可拆卸地附接到显影装置的显影剂盒，用于交换显影剂，并且具有与上述盒相同的部件; 用于驱动用于显影剂交换的显影剂盒的圆筒体的驱动装置; 检测单元，用于检测显影剂盒的设置装置以检测显影剂盒是否未使用或使用; 以及控制电路，用于根据来自检测单元的检测结果来控制驱动装置。