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21.发明授权
公开(公告)号：US5843468A
公开(公告)日：1998-12-01
申请号：US644922
申请日：1996-05-13
申请人： Terry L. Burkoth , Lina T. Taskovich , Russell D. Beste , Robert M. Gale , Eun Soo Lee , Richard D. Hamlin , Su LL Yum
发明人： Terry L. Burkoth , Lina T. Taskovich , Russell D. Beste , Robert M. Gale , Eun Soo Lee , Richard D. Hamlin , Su LL Yum
CPC分类号： A61K9/7053 , A61K47/14 , A61K9/0014 , A61K9/7069 , A61K9/7084 , Y10S514/946 , Y10S514/947
摘要： Compositions, devices, and methods for transdermal administration of an active agent are disclosed using a novel dual permeation enhancer mixture comprising lauryl acetate and a monoglyceride, preferably glycerol monolaurate. The dual permeation enhancer mixture comprising lauryl acetate is a potent permeation enhancer and provides stable systems which are more readily characterized.
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公开(公告)号：US5254349A
公开(公告)日：1993-10-19
申请号：US963962
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译： 公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。 剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。
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公开(公告)号：US5189986A
公开(公告)日：1993-03-02
申请号：US764436
申请日：1991-09-23
申请人： Terry L. Burkoth
发明人： Terry L. Burkoth
CPC分类号： A61K9/703 , A01K11/001 , A01K13/003 , A61D7/00
摘要： The present invention is directed to the veterinary transdermal application of an active agent to an animal. More particularly, the invention is directed to an active agent dispenser or apparatus attachable to the ear of an animal for the transdermal delivery of an active agent to the animal. The dispenser comprises an ear tag component and a transdermal device component, wherein the transdermal component is held tightly in active agent-transmitting relation to the ear of an animal by the ear tag component.
摘要翻译： 本发明涉及一种活性剂在动物中的兽医透皮应用。 更具体地说，本发明涉及可附着到动物耳朵的活性剂分配器或装置，用于将活性剂透皮递送至动物。 分配器包括耳标组件和透皮装置组件，其中透皮组分通过耳标构件紧密地保持在与动物耳朵的活性剂传递关系中。
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公开(公告)号：US5126142A
公开(公告)日：1992-06-30
申请号：US641023
申请日：1991-01-11
IPC分类号： A61K9/00
CPC分类号： A61K9/0068 , A61K31/70 , A61K9/0004
摘要： A dispenser is disclosed for delivering a beneficial ionophore to an animal. The dispenser comprises (1) a semipermeable housing defining an internal space, (2) at least one composition comprising an ionophore and a pharmaceutically acceptable carrier in the space, (3) an expandable hydrophilic composition in the space, (4) a dense member in the space, and (5) at least one exit passageway in the housing for delivering the ionophore from the dispenser.
摘要翻译： 公开了用于将有益离子载体输送到动物的分配器。 所述分配器包括（1）限定内部空间的半透性外壳，（2）至少一种组合物，其包含所述空间中的离子载体和药学上可接受的载体，（3）所述空间中的可膨胀的亲水性组合物，（4） 在空间中，和（5）壳体中的至少一个出口通道，用于从分配器输送离子载体。
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公开(公告)号：US3965144A
公开(公告)日：1976-06-22
申请号：US405237
申请日：1973-10-10
IPC分类号： C07C125/06
CPC分类号： C07C271/06
摘要： Compounds are provided for reducing erythemal response which are photoreactive precursors to para-aminobenzoic acid or its physiologically acceptable esters. Upon exposure to ultraviolet radiation of greater than about 280nm, the compounds of this invention undergo a photoreactive degradation to provide a regulated amount of a sunscreen material which screens out ultraviolet radiation which could lead to erythema.The compounds are benzyl esters of p-carboxycarbanilic acid and the dermatological and physiological acceptable esters of the carboxy group.
摘要翻译： 提供化合物用于减少红皮病反应，这是对氨基苯甲酸或其生理上可接受的酯的光反应性前体。 当暴露于大于约280nm的紫外线辐射时，本发明的化合物经历光反应性降解以提供调节量的防晒剂材料，其遮断可导致红斑的紫外线辐射。
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