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公开(公告)号：US20080152724A1
公开(公告)日：2008-06-26
申请号：US11963227
申请日：2007-12-21
申请人： Mark Hirsh
发明人： Mark Hirsh
CPC分类号： A61K33/18 , A61K9/0063 , A61K31/79 , A61K33/38 , A61K47/61 , A61K2300/00
摘要： Compositions for the treatment of periodontitis and methods of use thereof are described. The compositions contain a polymer-iodine complex. The polymer-iodine complex can be suspended in a pharmaceutically acceptable carrier in which the complex is stable and the iodine is stable in its elemental form and/or a combined form (e.g., iodine-iodide complex). In one embodiment, the complex is prepared by the reacting a synthetic or semi-synthetic ionic polymer, with iodine and/or an iodide. The complex will preferably deliver iodine over an extended period of time for example over several days (e.g., at least 3 days, preferably at least 4 days, more preferably at least 5 days, most preferably at least 6 days), preferably at least a week, more preferably at least two weeks. In one embodiment, the polymer-iodine complex forms a gel, alone or by the addition of one or more gelling agents, upon administration into a periodontal pocket. The polymer-iodine complex, or a gel containing the complex can also contain one or more additional active agents and/or pharmaceutically acceptable excipients. The composition is preferably formulated so that it can be administered by injection.
摘要翻译： 描述了治疗牙周炎的组合物及其使用方法。 组合物含有聚合物 - 碘络合物。 聚合物 - 碘络合物可以悬浮在药学上可接受的载体中，其中络合物是稳定的，并且碘以其元素形式和/或组合形式（例如碘 - 碘化物络合物）是稳定的。 在一个实施方案中，通过合成或半合成的离子聚合物与碘和/或碘化物反应来制备络合物。 络合物将优选在延长的时间段内递送碘，例如几天（例如，至少3天，优选至少4天，更优选至少5天，最优选至少6天），优选至少 周，更优选至少两周。 在一个实施方案中，聚合物 - 碘络合物在施用到牙周袋中时单独或通过加入一种或多种胶凝剂形成凝胶。 聚合物 - 碘络合物或含有络合物的凝胶也可以含有一种或多种另外的活性剂和/或药学上可接受的赋形剂。 组合物优选配制成可以通过注射给药。
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公开(公告)号：US06827946B2
公开(公告)日：2004-12-07
申请号：US10012202
申请日：2001-12-05
申请人： Mark Hirsh
发明人： Mark Hirsh
IPC分类号： A61K924
CPC分类号： A61K45/06 , A61K9/209 , A61K9/5084 , A61K31/00 , A61K2300/00
摘要： Compositions comprising both a sedative and a non-sedative antihistamine are disclosed as well as methods of inhibiting the release of histamines by administration of the compositions to a mammalian subject.
摘要翻译： 公开了包含镇静剂和非镇静抗组胺剂的组合物以及通过将组合物施用于哺乳动物受试者来抑制组胺释放的方法。
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公开(公告)号：US06312716B1
公开(公告)日：2001-11-06
申请号：US09562178
申请日：2000-05-02
申请人： Kamal K. Midha , Hans E. Junginger , Mark Hirsh
发明人： Kamal K. Midha , Hans E. Junginger , Mark Hirsh
IPC分类号： A61F1302
CPC分类号： A61K47/14 , A61K9/7023 , A61K31/137 , A61K47/12 , A61K47/22
摘要： The invention includes a patch and method for transdermal delivery of bupropion base. In the method of this invention, a patient is administered a bupropion base in an amount effective to alleviate withdrawal symptoms and to prevent or reduce craving of nicotine in said patient. Alternatively, an effective amount of bupropion base is delivered to alleviate depression in a patient or to treat obesity. A transdermal patch includes a bupropion base. The bupropion base can be mixed with an acceptable pharmaceutical carrier.
摘要翻译： 本发明包括用于安非他酮碱的透皮递送的贴剂和方法。 在本发明的方法中，患者以有效减轻戒断症状的量并且预防或减少所述患者中的尼古丁的渴望量施用安非他酮碱。 或者，递送有效量的安非他酮碱以缓解患者的抑郁症或治疗肥胖症。 透皮贴剂包括安非他酮碱。 安非他酮碱可与可接受的药物载体混合。
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公开(公告)号：US20080248135A1
公开(公告)日：2008-10-09
申请号：US11829386
申请日：2007-07-27
申请人： Mark Hirsh , Mark Vecchiotti
发明人： Mark Hirsh , Mark Vecchiotti
摘要： Otitis is treated with a combination of a controlled-release iodine preparation and a pH-lowering preparation. This prevents or delays the onset of antibiotic resistance among causative bacteria and fungi, and, by inhibiting protease activity, improves the rate of healing, and prevents Pseudomonas bacteria from spreading into the temporal bone.
摘要翻译： 用控制释放的碘制剂和pH降低制剂的组合治疗耳炎。 这可以防止或延缓致病菌和真菌之间的抗生素抗性的发生，并通过抑制蛋白酶活性，提高愈合速度，并防止假单胞菌细菌扩散到颞骨中。
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