公开(公告)号：US12115186B1

公开(公告)日：2024-10-15

申请号：US18094349

申请日：2023-01-07

申请人： CYNDIE HOLST FAMILY TRUST

发明人： John Edwin Ruyak

IPC分类号： A61K33/30 ,  A61K9/00 ,  A61K31/63 ,  A61K31/635 ,  A61K31/717 ,  A61K31/79 ,  A61K33/18 ,  A61K33/38 ,  A61K35/644 ,  A61K36/28 ,  A61K36/886

CPC分类号： A61K33/30 ,  A61K9/0014 ,  A61K31/63 ,  A61K31/635 ,  A61K31/717 ,  A61K31/79 ,  A61K33/18 ,  A61K33/38 ,  A61K35/644 ,  A61K36/28 ,  A61K36/886

摘要： A topical burn cream includes zinc oxide in an amount equal to about 72 percent by weight; sulfanilamide in an amount equal to about 18 percent by weight; and iodine in an amount equal to about 0.09 percent by weight.

公开(公告)号：US20240197773A1

公开(公告)日：2024-06-20

申请号：US18594231

申请日：2024-03-04

申请人： Harrow IP, LLC

发明人： William Stringer ,  Michael Hanrahan ,  Patrick H. Witham

IPC分类号： A61K31/79 ,  A61F9/00 ,  A61K31/765 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/24 ,  A61K47/26

CPC分类号： A61K31/79 ,  A61F9/0008 ,  A61K31/765 ,  A61K47/02 ,  A61K47/10 ,  A61K47/183 ,  A61K47/24 ,  A61K47/26

摘要： Provided herein are formulations and compositions for ocular diseases or disorders such as dry eye disease. Further provided herein are methods for manufacturing ocular formulations and compositions.

公开(公告)号：US11833161B2

公开(公告)日：2023-12-05

申请号：US17967470

申请日：2022-10-17

申请人： Pedicis Research LLC

发明人： Robert Alonso ,  Lawrence Stoll

IPC分类号： A61K31/60 ,  A61K31/045 ,  A61K31/19 ,  A61K31/197 ,  A61K31/22 ,  A61K31/375 ,  A61K31/79 ,  A61K47/10 ,  A61K47/18 ,  A61P17/12 ,  A61K8/368 ,  A61K8/37 ,  A61Q19/00 ,  A61K8/81 ,  A61K8/20 ,  A61K47/38 ,  A61P31/20 ,  A61K9/00 ,  A61K9/06

CPC分类号： A61K31/60 ,  A61K8/20 ,  A61K8/368 ,  A61K8/37 ,  A61K8/8176 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/045 ,  A61K31/19 ,  A61K31/197 ,  A61K31/22 ,  A61K31/375 ,  A61K31/79 ,  A61K47/10 ,  A61K47/18 ,  A61K47/38 ,  A61P17/12 ,  A61P31/20 ,  A61Q19/005 ,  A61K31/60 ,  A61K2300/00 ,  A61K31/19 ,  A61K2300/00 ,  A61K31/045 ,  A61K2300/00 ,  A61K31/375 ,  A61K2300/00 ,  A61K31/197 ,  A61K2300/00

摘要： A pharmaceutical composition for treating skin infections is described herein. A method using a pharmaceutical composition for treating skin infections is described herein. A pharmaceutical composition for treating skin infections may comprise, in 100 parts of the composition, 1-99 parts of a pharmaceutically acceptable excipient; 99-1 parts of a keratolytic; 99-1 parts ethyl pyruvate; and 99-1 parts povidone iodine. A method for treating skin infections may comprise topical application of a composition to an infected skin cell for a treatment period.

公开(公告)号：US20230345938A1

公开(公告)日：2023-11-02

申请号：US18130042

申请日：2023-04-03

申请人： SMITH & NEPHEW, INC.

发明人： Aleksa JOVANOVIC ,  Lei SHI ,  Eric ROCHE ,  Paul RENICK

IPC分类号： A01N37/02 ,  A01N59/12 ,  A01N59/16 ,  A61L31/16 ,  A61K33/18 ,  A61K33/38 ,  A61L27/54 ,  A61L29/16 ,  A61L31/10 ,  A61L27/34 ,  A61L29/08 ,  A01N37/46 ,  A61L26/00 ,  A01N25/30 ,  A61L31/14 ,  A61L29/14 ,  A61L27/52 ,  A61K31/23 ,  A61K47/26 ,  A61K47/38 ,  A61K45/06 ,  A61K47/14 ,  A61K47/10 ,  A61K9/00 ,  A61K31/625 ,  A61P31/04 ,  A01N25/04 ,  A61K9/06 ,  A61K31/25 ,  A61K31/7036 ,  A61K31/79 ,  A61K38/12 ,  A61L27/02 ,  A61L27/04 ,  A61L27/30 ,  A61L29/02 ,  A61L29/10 ,  A61L31/02 ,  A61L31/08

CPC分类号： A01N37/02 ,  A01N59/12 ,  A01N59/16 ,  A61L31/16 ,  A61K33/18 ,  A61K33/38 ,  A61L27/54 ,  A61L29/16 ,  A61L31/10 ,  A61L27/34 ,  A61L29/085 ,  A01N37/46 ,  A61L26/0066 ,  A01N25/30 ,  A61L31/145 ,  A61L29/145 ,  A61L27/52 ,  A61K31/23 ,  A61K47/26 ,  A61K47/38 ,  A61K45/06 ,  A61K47/14 ,  A61K47/10 ,  A61K9/0014 ,  A61K31/625 ,  A61P31/04 ,  A01N25/04 ,  A61K9/06 ,  A61K31/25 ,  A61K31/7036 ,  A61K31/79 ,  A61K38/12 ,  A61L27/025 ,  A61L27/047 ,  A61L27/306 ,  A61L29/02 ,  A61L29/106 ,  A61L31/022 ,  A61L31/028 ,  A61L31/088 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2420/04

摘要： The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.

公开(公告)号：US20230321139A1

公开(公告)日：2023-10-12

申请号：US17714465

申请日：2022-04-06

申请人： Mary Crawford ,  Jonathon Crawford

发明人： Mary Crawford ,  Jonathon Crawford

IPC分类号： A61K33/06 ,  A61K31/17 ,  A61K47/46 ,  A61K47/06 ,  A61K31/79 ,  A61K31/473 ,  A61K31/15 ,  A61K31/045 ,  A61K31/345 ,  A61K31/34 ,  A61K9/00 ,  A61P17/02

CPC分类号： A61K33/06 ,  A61K31/17 ,  A61K47/46 ,  A61K47/06 ,  A61K31/79 ,  A61K31/473 ,  A61K31/15 ,  A61K31/045 ,  A61K31/345 ,  A61K31/34 ,  A61K9/0014 ,  A61P17/02

摘要： Wound-care composition and method of use. The composition comprises: a substrate; potassium alum; and urea. The potassium alum makes up 10.27 wt. % of the composition within a tolerance of +/- 50%; and the urea makes up 0.12 wt. % of the composition within a tolerance of +/- 50%. The method comprises applying the composition to a wound on a non-human animal.

公开(公告)号：US11641856B2

公开(公告)日：2023-05-09

申请号：US17545409

申请日：2021-12-08

申请人： SMITH & NEPHEW, INC.

发明人： Aleksa Jovanovic ,  Lei Shi ,  Eric Roche ,  Paul Renick

IPC分类号： A01N59/12 ,  A61L29/16 ,  A01N37/02 ,  A01N59/16 ,  A61L31/16 ,  A61K33/18 ,  A61K33/38 ,  A61L27/54 ,  A61L31/10 ,  A61L27/34 ,  A61L29/08 ,  A01N37/46 ,  A61L26/00 ,  A01N25/30 ,  A61L31/14 ,  A61L29/14 ,  A61L27/52 ,  A61K31/23 ,  A61K47/26 ,  A61K47/38 ,  A61K45/06 ,  A61K47/14 ,  A61K47/10 ,  A61K9/00 ,  A61K31/625 ,  A61P31/04 ,  A01N25/04 ,  A61K9/06 ,  A61K31/25 ,  A61K31/7036 ,  A61K31/79 ,  A61K38/12 ,  A61L27/02 ,  A61L27/04 ,  A61L27/30 ,  A61L29/02 ,  A61L29/10 ,  A61L31/02 ,  A61L31/08

CPC分类号： A01N37/02 ,  A01N25/04 ,  A01N25/30 ,  A01N37/46 ,  A01N59/12 ,  A01N59/16 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/23 ,  A61K31/25 ,  A61K31/625 ,  A61K31/7036 ,  A61K31/79 ,  A61K33/18 ,  A61K33/38 ,  A61K38/12 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38 ,  A61L26/0066 ,  A61L27/025 ,  A61L27/047 ,  A61L27/306 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/02 ,  A61L29/085 ,  A61L29/106 ,  A61L29/145 ,  A61L29/16 ,  A61L31/022 ,  A61L31/028 ,  A61L31/088 ,  A61L31/10 ,  A61L31/145 ,  A61L31/16 ,  A61P31/04 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2420/04 ,  A61K33/38 ,  A61K2300/00 ,  A61K33/18 ,  A61K2300/00 ,  A61K31/7036 ,  A61K2300/00 ,  A61K31/625 ,  A61K2300/00 ,  A61K31/23 ,  A61K2300/00

摘要： The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.

公开(公告)号：US20180228863A1

公开(公告)日：2018-08-16

申请号：US15750460

申请日：2016-08-05

申请人： The Johns Hopkins University

发明人： Thomas Jozefiak ,  Michael Parlato ,  Pratik Patel ,  Kevin Colbert ,  Ashish Nimgaonkar ,  Pankaj Pasricha

IPC分类号： A61K38/02 ,  A61K9/20 ,  A61K47/26 ,  A61K9/16 ,  A61K9/50

CPC分类号： A61K38/02 ,  A61K9/0095 ,  A61K9/06 ,  A61K9/08 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50 ,  A61K31/722 ,  A61K31/79 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38

摘要： The present invention provides compositions and methods for treatment of metabolic syndromes. Namely, the presently disclosed compositions and methods are provided for affecting the function of the gastrointestinal endocrine system in key regions of the gut, thereby, producing therapeutic effects on obesity, diabetes and other metabolic disorders. The compositions include components for forming luminal barriers within the gastrointestinal tract of a subject where the barrier is created in-situ via interaction of resident mucin with the mucin-interacting agent.

公开(公告)号：US20180169138A1

公开(公告)日：2018-06-21

申请号：US15886978

申请日：2018-02-02

申请人： Cytosorbents Corporation

发明人： Humayra Begum Ali ,  Thomas D. Golobish ,  Vincent J. Capponi ,  Phillip P. Chan ,  Wei Tai Young ,  Andrew Robert Scheirer

IPC分类号： A61K31/765 ,  A61K9/00

CPC分类号： A61K31/765 ,  A61K9/0053 ,  A61K31/75 ,  A61K31/79 ,  A61P1/00 ,  A61P1/04 ,  A61P1/06

摘要： Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).

公开(公告)号：US09987297B2

公开(公告)日：2018-06-05

申请号：US13192007

申请日：2011-07-27

申请人： Sébastien Ladet

发明人： Sébastien Ladet

IPC分类号： A61L24/04 ,  C07K2/00 ,  C07K17/02 ,  A61K31/7088 ,  A61K38/02 ,  A61K31/722 ,  C08B37/08 ,  A61K38/39 ,  C07K14/78 ,  A61K31/37 ,  C08B3/00 ,  A61K31/717 ,  A61P17/02 ,  A61P41/00 ,  A61K31/737 ,  A61K31/745 ,  A61K31/765 ,  A61K31/78 ,  A61K31/785 ,  A61K31/79 ,  A61L17/00 ,  A61L24/00 ,  A61L31/04 ,  A61L31/14 ,  D01F11/14

CPC分类号： A61K31/7088 ,  A61K31/717 ,  A61K31/722 ,  A61K31/737 ,  A61K31/745 ,  A61K31/765 ,  A61K31/78 ,  A61K31/785 ,  A61K31/79 ,  A61L17/00 ,  A61L24/001 ,  A61L24/04 ,  A61L31/04 ,  A61L31/14 ,  D01F11/14

摘要： A method for bonding a polymeric fiber to tissue is provided which includes providing a polymeric fiber having a plurality of tissue reactive members linked to a surface of the fiber via a specific binding pair, and contacting the polymeric fiber to biological tissue, to covalently bond the fiber to the tissue.

公开(公告)号：US09907741B2

公开(公告)日：2018-03-06

申请号：US15041200

申请日：2016-02-11

申请人： Luromed LLC

发明人： Adelya K. Leshchiner ,  Nancy E. Larsen ,  Edward G. Parent

IPC分类号： A61K8/73 ,  A61K47/36 ,  A61K8/04 ,  A61K9/06 ,  A61K9/00 ,  A61K31/00 ,  A61K31/4015 ,  A61K31/573 ,  A61K33/18 ,  A61K45/06 ,  A61Q19/00 ,  A61K8/36 ,  A61K8/37 ,  A61K8/60 ,  A61K8/67 ,  A61K31/165 ,  A61K31/79 ,  A61K38/12 ,  A61Q17/04 ,  A61K8/34 ,  A61K8/42 ,  A61K8/49 ,  A61K8/97

CPC分类号： A61K8/735 ,  A61K8/042 ,  A61K8/345 ,  A61K8/36 ,  A61K8/37 ,  A61K8/42 ,  A61K8/4973 ,  A61K8/60 ,  A61K8/676 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/0046 ,  A61K9/06 ,  A61K31/00 ,  A61K31/165 ,  A61K31/4015 ,  A61K31/573 ,  A61K31/79 ,  A61K33/18 ,  A61K38/12 ,  A61K45/06 ,  A61K47/36 ,  A61K2800/10 ,  A61K2800/28 ,  A61K2800/524 ,  A61K2800/592 ,  A61K2800/74 ,  A61Q17/04 ,  A61Q19/00 ,  A61K2300/00

摘要： Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.