公开(公告)号：US07063833B2

公开(公告)日：2006-06-20

申请号：US10694130

申请日：2003-10-27

申请人： William Michael Glandorf ,  Lori Ann Bacca

发明人： William Michael Glandorf ,  Lori Ann Bacca

IPC分类号： A61K8/46

CPC分类号： A61Q11/00 ,  A61K8/21 ,  A61K8/24 ,  A61K2800/52 ,  A61K2800/88

摘要： Disclosed are methods for reducing the staining of dentifrice composition containing stannous comprising administering to a subject the dentifrice composition. The dentifrice composition is a dual phase dentifrice and is contained in physically separated compartments of a dentifrice dispenser. The first dentifrice composition comprises an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more and has a total water content of up to about 20%. The second dentifrice composition comprises an effective amount of stannous ions. The molar ratio of polyphosphate anion to stannous ion is from about 0.2:1 to about 5:1 and the efficacy of the stannous ion in the dentifrice is not reduced by the polyphosphate. The dentifrice composition may alternatively be a single phase dentifrice. The single phase dentifrice will comprise an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more and an effective amount of a stannous ion. The single phase dentifrice has a total water content of up to about 20%, the stannous ion is not delivered from stannous fluoride, a molar ratio of polyphosphate anion to stannous ion is from about 0.2:1 to about 5:1, and the efficacy of the stannous ion in the dentifrice is not reduced by the polyphosphate.

摘要翻译： 公开了减少含有亚锡的牙粉组合物染色的方法，包括向受试者施用洁齿剂组合物。 洁牙剂组合物是双相洁齿剂，并且包含在洁齿剂分配器的物理分离的隔室中。 第一洁牙剂组合物包含有效量的一种或多种平均链长为约4或更大并且总含水量高达约20％的线性多磷酸盐。 第二洁牙剂组合物包含有效量的亚锡离子。 多磷酸根阴离子与亚锡离子的摩尔比为约0.2:1至约5:1，并且多磷酸盐不会降低洁牙剂中的亚锡离子的功效。 洁齿剂组合物可以替代地是单相洁齿剂。 单相洁齿剂将包含有效量的一种或多种平均链长为约4或更大的线性多磷酸酯和有效量的亚锡离子。 单相洁齿剂的总含水量高达约20％，亚锡离子不会从氟化亚锡输送，多磷酸根阴离子与亚锡离子的摩尔比为约0.2:1至约5:1，效力 的洁齿剂中的亚锡离子不被多磷酸盐还原。

公开(公告)号：US06682722B2

公开(公告)日：2004-01-27

申请号：US10233880

申请日：2002-09-03

申请人： Satyanarayana Majeti ,  Niteen Vasant Bapat ,  Paula Denise Clymer ,  Elizabeth Ann Reno ,  William Michael Glandorf ,  Stephen Andras Kovacs

发明人： Satyanarayana Majeti ,  Niteen Vasant Bapat ,  Paula Denise Clymer ,  Elizabeth Ann Reno ,  William Michael Glandorf ,  Stephen Andras Kovacs

IPC分类号： A61K716

CPC分类号： A61Q11/02 ,  A61K8/24 ,  A61K8/8182 ,  A61Q11/00

摘要： Disclosed are oral care compositions and methods for overall cleaning, whitening and preventing, reducing or removing surface deposited stains on natural teeth and dental prosthesis, the compositions comprising in an orally acceptable carrier at least 0.1% by weight of a water-soluble or water-dispersible copolymer prepared by copolymerizing one or a mixture of vinyl pyrrolidone (VP) monomers with one or a mixture of C1-C19 alkyl carboxylic acid (AC) C2-C12 alkenyl ester monomers. Preferably, the compositions further comprise one or a mixture of other oral care agents selected from a water soluble alkali metal or ammonium tripolyphosphate in an amount at least about 0.5% by weight of the composition, an abrasive, preferably a precipitated silica abrasive, in an amount at least about 6% by weight of the composition and a bleaching agent in an amount at least about 0.1% by weight of the composition. This invention further relates to methods of cleaning, whitening and polishing natural teeth and dental prosthesis and of preventing, reducing or removing surface deposited stains from teeth by administering the present compositions.

摘要翻译： 公开了用于整体清洁，增白和预防，减少或去除天然牙齿和假牙上的表面沉积污渍的口腔护理组合物和方法，所述组合物在口腔可接受的载体中包含至少0.1重量％的水溶性或水溶性的， 通过将乙烯基吡咯烷酮（VP）单体的一种或混合物与C1-C19烷基羧酸（AC）C2-C12烯基酯单体的一种或混合物共聚制备的可分散共聚物。 优选地，组合物还包含选自水溶性碱金属或三聚磷酸铵的其它口腔护理剂的一种或其混合物，其量为组合物重量的至少约0.5％，研磨剂，优选沉淀二氧化硅研磨剂， 至少约6重量％的组合物和漂白剂，其量为组合物的至少约0.1重量％。 本发明还涉及通过施用本发明的组合物来清洁，增白和抛光天然牙齿和牙科假体以及防止，减少或去除牙齿表面沉积的污渍的方法。

公开(公告)号：US5820854A

公开(公告)日：1998-10-13

申请号：US829491

申请日：1997-03-27

申请人： William Michael Glandorf

发明人： William Michael Glandorf

IPC分类号： A61K8/19 ,  A61K8/22 ,  A61K8/24 ,  A61K8/73 ,  A61K8/86 ,  A61K8/90 ,  A61Q11/00 ,  A61K7/18

CPC分类号： A61K8/24 ,  A61K8/19 ,  A61K8/22 ,  A61K8/73 ,  A61K8/731 ,  A61K8/86 ,  A61K8/90 ,  A61Q11/00 ,  A61K2800/88

摘要： The present invention relates a dentifrice formulation contained in physically separated compartments of a dispenser, comprising a first dentifrice composition having an ionic strength of from about 1,000 .mu.mho to about 50,000 .mu.mho comprising from about 0.1% to about 8% of a polyoxyethylene having a molecular weight of from about 200,000 to about 7,000,000 and from about 92% to about 99.5% of one or more aqueous carriers; and a second dentifrice composition. The present invention also relates to a dentifrice formulation contained in physically separated compartments of a dispenser, comprising a first dentifrice composition having an ionic strength of from about 1,000 .mu.mho to about 50,000 .mu.mho; and a second dentifrice composition comprising from about 0.1% to about 8% of a polyoxyethylene having a molecular weight of from about 200,000 to about 7,000,000 and from about 92% to about 99.9% of one or more aqueous carriers. The present invention also relates to a dentifrice composition having an ionic strength of from about 1,000 .mu.mho to about 50,000 .mu.mho comprising from about 0.1% to about 8% of a polyoxyethylene having a molecular weight of from about 200,000 to about 7,000,000 and from about 92% to about 99.9% of one or more aqueous carriers.

摘要翻译： 本发明涉及包含在分配器的物理分离的隔室中的洁牙剂制剂，其包含第一洁牙剂组合物，其具有约1,000μm至约50,000μmhoho的离子强度，包含约0.1％至约8％的聚氧乙烯，其具有 分子量为约200,000至约700,000和约92％至约99.5％的一种或多种含水载体; 和第二洁牙剂组合物。 本发明还涉及包含在分配器的物理分离的隔室中的洁牙剂制剂，其包含离子强度为约1,000μm至约50,000μmhoho的第一洁牙剂组合物; 以及第二洁齿剂组合物，其包含约0.1％至约8％的分子量为约200,000至约700,000和约92％至约99.9％的一种或多种含水载体的聚氧乙烯。 本发明还涉及一种洁牙剂组合物，该洁牙剂组合物的离子强度为约1,000μm至约50,000μmho，包含约0.1％至约8％的分子量为约200,000至约700,000的聚氧乙烯和约 92％至约99.9％的一种或多种含水载体。