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    Method of reducing staining of stannous in dentifrice compositions
    1.
    发明授权
    Method of reducing staining of stannous in dentifrice compositions 有权
    减少洁牙剂组合物中亚锡染色的方法

    公开(公告)号：US06350436B1

    公开(公告)日：2002-02-26

    申请号：US09451420

    申请日：1999-11-30

    申请人： William Michael Glandorf ,  Lori Ann Bacca

    发明人： William Michael Glandorf ,  Lori Ann Bacca

    IPC分类号： A61K716

    CPC分类号： A61Q11/00 ,  A61K8/21 ,  A61K8/24 ,  A61K2800/52 ,  A61K2800/88

    摘要： Disclosed are methods for reducing the staining of dentifrice composition containing stannous comprising administering to a subject the dentifrice composition. The dentifrice composition is a dual phase dentifrice and is contained in physically separated compartments of a dentifrice dispenser. The first dentifrice composition comprises an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more and has a total water content of up to about 20%. The second dentifrice composition comprises an effective amount of stannous ions. The molar ratio of polyphosphate anion to stannous ion is from about 0.2:1 to about 5:1 and the efficacy of the stannous ion in the dentifrice is not reduced by the polyphosphate. The dentifrice composition may alternatively be a single phase dentifrice. The single phase dentifrice will comprise an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more and an effective amount of a stannous anion. The single phase dentifrice has a total water content of up to about 20%, the stannous ion is not delivered from stannous fluoride, a molar ratio of polyphosphate anion to stannous ion is from about 0.2:1 to about 5:1, and the efficacy of the stannous ion in the dentifrice is not reduced by the polyphosphate.

    摘要翻译： 公开了减少含有亚锡的牙粉组合物染色的方法，包括向受试者施用洁齿剂组合物。 洁牙剂组合物是双相洁齿剂，并且包含在洁齿剂分配器的物理分离的隔室中。 第一洁牙剂组合物包含有效量的一种或多种平均链长为约4或更大并且总含水量高达约20％的线性多磷酸盐。 第二洁牙剂组合物包含有效量的亚锡离子。 多磷酸根阴离子与亚锡离子的摩尔比为约0.2:1至约5:1，并且多磷酸盐不会降低洁牙剂中的亚锡离子的功效。 洁齿剂组合物可以替代地是单相洁齿剂。 单相洁齿剂将包含有效量的一种或多种平均链长为约4或更大的线性多磷酸酯和有效量的亚锡阴离子。 单相洁齿剂的总含水量高达约20％，亚锡离子不会从氟化亚锡输送，多磷酸根阴离子与亚锡离子的摩尔比为约0.2:1至约5:1，效力 的洁齿剂中的亚锡离子不被多磷酸盐还原。

    Method of reducing staining of stannous in dentifrice compositions
    2.
    发明授权
    Method of reducing staining of stannous in dentifrice compositions 有权

    公开(公告)号：US06667027B2

    公开(公告)日：2003-12-23

    申请号：US10039620

    申请日：2001-10-24

    申请人： William Michael Glandorf ,  Lori Ann Bacca

    发明人： William Michael Glandorf ,  Lori Ann Bacca

    IPC分类号： A61K716

    CPC分类号： A61Q11/00 ,  A61K8/21 ,  A61K8/24 ,  A61K2800/52 ,  A61K2800/88

    摘要： Disclosed are methods for reducing the staining of dentifrice composition containing stannous comprising administering to a subject the dentifrice composition. The dentifrice composition is a dual phase dentifrice and is contained in physically separated compartments of a dentifrice dispenser. The first dentifrice composition comprises an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more and has a total water content of up to about 20%. The second dentifrice composition comprises an effective amount of stannous ions. The molar ratio of polyphosphate anion to stannous ion is from about 0.2:1 to about 5:1 and the efficacy of the stannous ion in the dentifrice is not reduced by the polyphosphate. The dentifrice composition may alternatively be a single phase dentifrice. The single phase dentifrice will comprise an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more and an effective amount of a stannous anion. The single phase dentifrice has a total water content of up to about 20%, the stannous ion is not delivered from stannous fluoride, a molar ratio of polyphosphate anion to stannous ion is from about 0.2:1 to about 5:1, and the efficacy of the stannous ion in the dentifrice is not reduced by the polyphosphate.

    Method of reducing staining of stannous in dentifrice compositions
    3.
    发明授权
    Method of reducing staining of stannous in dentifrice compositions 失效
    减少洁牙剂组合物中亚锡染色的方法

    公开(公告)号：US07063833B2

    公开(公告)日：2006-06-20

    申请号：US10694130

    申请日：2003-10-27

    申请人： William Michael Glandorf ,  Lori Ann Bacca

    发明人： William Michael Glandorf ,  Lori Ann Bacca

    IPC分类号： A61K8/46

    CPC分类号： A61Q11/00 ,  A61K8/21 ,  A61K8/24 ,  A61K2800/52 ,  A61K2800/88

    摘要： Disclosed are methods for reducing the staining of dentifrice composition containing stannous comprising administering to a subject the dentifrice composition. The dentifrice composition is a dual phase dentifrice and is contained in physically separated compartments of a dentifrice dispenser. The first dentifrice composition comprises an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more and has a total water content of up to about 20%. The second dentifrice composition comprises an effective amount of stannous ions. The molar ratio of polyphosphate anion to stannous ion is from about 0.2:1 to about 5:1 and the efficacy of the stannous ion in the dentifrice is not reduced by the polyphosphate. The dentifrice composition may alternatively be a single phase dentifrice. The single phase dentifrice will comprise an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more and an effective amount of a stannous ion. The single phase dentifrice has a total water content of up to about 20%, the stannous ion is not delivered from stannous fluoride, a molar ratio of polyphosphate anion to stannous ion is from about 0.2:1 to about 5:1, and the efficacy of the stannous ion in the dentifrice is not reduced by the polyphosphate.

    摘要翻译： 公开了减少含有亚锡的牙粉组合物染色的方法，包括向受试者施用洁齿剂组合物。 洁牙剂组合物是双相洁齿剂，并且包含在洁齿剂分配器的物理分离的隔室中。 第一洁牙剂组合物包含有效量的一种或多种平均链长为约4或更大并且总含水量高达约20％的线性多磷酸盐。 第二洁牙剂组合物包含有效量的亚锡离子。 多磷酸根阴离子与亚锡离子的摩尔比为约0.2:1至约5:1，并且多磷酸盐不会降低洁牙剂中的亚锡离子的功效。 洁齿剂组合物可以替代地是单相洁齿剂。 单相洁齿剂将包含有效量的一种或多种平均链长为约4或更大的线性多磷酸酯和有效量的亚锡离子。 单相洁齿剂的总含水量高达约20％，亚锡离子不会从氟化亚锡输送，多磷酸根阴离子与亚锡离子的摩尔比为约0.2:1至约5:1，效力 的洁齿剂中的亚锡离子不被多磷酸盐还原。

    Stannous oral compositions
    5.
    发明授权
    Stannous oral compositions 有权
    亚锡口腔成分

    公开(公告)号：US06821507B2

    公开(公告)日：2004-11-23

    申请号：US10351205

    申请日：2003-01-24

    申请人： William M. Glandorf ,  Lori Ann Bacca ,  Donald J. White, Jr. ,  Henk J. Busscher

    发明人： William M. Glandorf ,  Lori Ann Bacca ,  Donald J. White, Jr. ,  Henk J. Busscher

    IPC分类号： A61K716

    CPC分类号： A61K8/731 ,  A61K8/19 ,  A61K8/21 ,  A61K8/24 ,  A61K8/365 ,  A61K8/73 ,  A61K8/81 ,  A61K8/8147 ,  A61K8/90 ,  A61K2800/88 ,  A61Q11/00

    摘要： The present invention relates to oral compositions comprising a stannous ion source, a fluoride ion source, and a polymeric mineral surface active agent that binds stannous, said compositions providing adequate therapeutic efficacy with minimal side effects of tooth staining and astringency. The composition simultaneously provides reduction and control of supragingival calculus. The present oral care compositions may be formulated as single phase or dual phase compositions. The present invention also provides a method for effective delivery of stannous-containing compositions with minimal side effects of tooth staining or astringency and with effective tartar control by administering to a subject a stable dentifrice composition comprising a clinically effective amount of stannous fluoride and/or other stannous salts in combination with a fluoride ion source and a polymeric mineral surface active agent, preferably a phosphate- or phosphonate-containing polymer.

    摘要翻译： 本发明涉及包含亚锡离子源，氟离子源和结合亚锡的聚合物矿物表面活性剂的口腔组合物，所述组合物提供足够的治疗功效，同时牙齿染色和涩味的副作用最小。 该组合物同时提供减少和控制龈上结石。 本口服护理组合物可以配制成单相或双相组合物。 本发明还提供了一种有效递送含有亚锡的组合物的方法，其具有最少的牙齿染色或涩味的副作用，并且通过向受试者施用稳定的洁牙剂组合物，其包含临床有效量的氟化亚锡和/或其它 亚硝酸盐与氟离子源和聚合物矿物表面活性剂，优选含磷酸盐或膦酸盐的聚合物组合。