公开(公告)号：US4272534A

公开(公告)日：1981-06-09

申请号：US134311

申请日：1980-03-26

申请人： Jean-Claude Aloup ,  Jean Bouchaudon ,  Daniel Farge ,  Claude James

发明人： Jean-Claude Aloup ,  Jean Bouchaudon ,  Daniel Farge ,  Claude James

IPC分类号： C07D213/26 ,  C07D213/32 ,  A61K31/44 ,  A61K31/495 ,  C07D413/14

CPC分类号： C07D213/26 ,  C07D213/32

摘要： Compounds of the formula: ##STR1## wherein R represents hydrogen or alkyl of 1 through 4 carbon atoms, and R.sub.1 and R.sub.2 represent hydrogen or alkyl of 1 through 15 carbon atoms, or alkyl of 1 through 15 carbon atoms substituted by one substituent selected from (i) hydroxy, (ii) alkylamino in which the alkyl radical is of 1 through 4 carbon atoms, (iii) dialkylamino in which the alkyl radicals are of 1 through 4 carbon atoms, (iv) phenyl, (v) carboxy, and (vi) alkoxycarbonyl in which the alkoxy radical is of 1 through 4 carbon atoms, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached represent a five- or six-membered heterocyclic radical, are new compounds. They possess pharmacological properties and are particularly useful in the treatment of gastro-intestinal ulcers.

摘要翻译： 下式的化合物：其中R表示氢或1至4个碳原子的烷基，R1和R2表示氢或1至15个碳原子的烷基，或1至15个碳原子的烷基，被一个选自 （i）羟基，（ii）其中烷基为1至4个碳原子的烷基氨基，（iii）烷基具有1至4个碳原子的二烷基氨基，（iv）苯基，（v）羧基和 （vi）其中烷氧基为1至4个碳原子的烷氧基羰基，或R1和R2与它们所连接的氮原子一起代表五或六元杂环基，是新的化合物。 它们具有药理学性质，特别可用于治疗胃肠溃疡。

公开(公告)号：US4959385A

公开(公告)日：1990-09-25

申请号：US299039

申请日：1989-01-19

申请人： David C. Cook ,  Terance W. Hart ,  Iain M. McLay ,  Malcolm N. Palfreyman ,  Roger J. Walsh ,  Jean-Claude Aloup

发明人： David C. Cook ,  Terance W. Hart ,  Iain M. McLay ,  Malcolm N. Palfreyman ,  Roger J. Walsh ,  Jean-Claude Aloup

IPC分类号： A61K8/00 ,  A61K8/11 ,  A61K8/46 ,  A61K31/38 ,  A61K31/381 ,  A61K31/382 ,  A61P9/08 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/02 ,  A61Q5/00 ,  C07D333/38 ,  C07D333/48 ,  C07D335/02 ,  C07D337/04

CPC分类号： C07D333/48 ,  C07D333/38 ,  C07D335/02

摘要： This invention relates to thioformamide derivatives of the formula: ##STR1## wherein R represents alkyl, Ar represents optionally substituted phenyl, Y represents an ethylene or methylene radical or a valency bond, and n represents 0 or 1, bioprecursors thereof and pharmaceutically acceptable salts thereof which possess useful pharmacological properties, processes for their preparation and compositions containing them.

公开(公告)号：US4751234A

公开(公告)日：1988-06-14

申请号：US766199

申请日：1985-08-16

申请人： Jean-Claude Aloup ,  Jean Bouchaudon ,  Daniel Farge ,  Claude James

发明人： Jean-Claude Aloup ,  Jean Bouchaudon ,  Daniel Farge ,  Claude James

IPC分类号： C07D495/04 ,  A61K31/395 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/47 ,  A61K31/50 ,  A61P9/12 ,  C07D409/04 ,  C07D215/60

CPC分类号： C07D409/04

摘要： Thioformamide derivatives of the formula: ##STR1## wherein R is hydrogen or alkyl (1 to 4 C), Het is pyridin-3-yl[optionally substituted by alkyl (1 to 4 C) or a halogen], quinolin-3-yl, pyridazin-4-yl, pyrimidin-5-yl, thiazol-5-yl, thieno[2,3-b]pyridin-5-yl or thieno[3,2-b]pyridin-6-yl, and Y is a valency bond or a methylene radical, are new compounds, which are particularly useful as antihypertensive agents.

摘要翻译： 其中R是氢或烷基（1-4C），Het是任选被烷基（1至4 C）或卤素取代的吡啶-3-基]喹啉-3-基， ，哒嗪-4-基，嘧啶-5-基，噻唑-5-基，噻吩并[2,3-b]吡啶-5-基或噻吩并[3,2-b]吡啶-6-基，Y为 化合键或亚甲基是新的化合物，其特别可用作抗高血压剂。