利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

82 条记录 (耗时 0.047 秒)

    2' and 3'-nucleoside prodrugs for treating Flaviviridae infections
    24.
    发明申请
    2' and 3'-nucleoside prodrugs for treating Flaviviridae infections 审中-公开
    2'和3'-核苷前药用于治疗黄病毒科感染

    公开(公告)号：US20070060541A1

    公开(公告)日：2007-03-15

    申请号：US11005466

    申请日：2004-12-06

    申请人： Gilles Gosselin ,  Richard Storer ,  Paola LaColla ,  Jean-Pierre Sommadossi

    发明人： Gilles Gosselin ,  Richard Storer ,  Paola LaColla ,  Jean-Pierre Sommadossi

    IPC分类号： A61K31/7072 ,  C07H19/04 ,  A61K38/14

    CPC分类号： C07K9/003 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/00 ,  A61K45/06 ,  C07H19/06 ,  C07H19/067 ,  A61K2300/00

    摘要： 2′ and 3′-Prodrugs of 1′, 2′, 3′ or 4′-branched β-D or β-L nucleosides, or their pharmaceutically acceptable salts and derivatives are described, which are useful in the prevention and treatment of Flaviviridae infections and other related conditions. These modified nucleosides provide superior results against flaviviruses and pestiviruses, including hepatitis C virus and viruses generally that replicate through an RNA dependent RNA reverse transcriptase. Compounds, compositions, methods and uses are provided for the treatment of Flaviviridae infection, including HCV infection, that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.

    摘要翻译： 描述了1'，2'，3'或4'-支链β-D或β-L核苷的2'和3'-前药，或其药学上可接受的盐和衍生物，其可用于预防和治疗黄病毒科 感染等相关条件。 这些修饰的核苷对黄病毒和瘟病毒提供了优异的结果，包括丙型肝炎病毒和通常通过RNA依赖性RNA逆转录酶复制的病毒。 提供化合物，组合物，方法和用途用于治疗包括HCV感染在内的黄病毒科感染，包括施用有效量的本发明前药或其药学上可接受的盐或衍生物。 这些药物可以任选地与另外的抗病毒剂组合或改变来施用，以预防或治疗黄病毒科感染和其他相关病症。

    Substituted phenylindoles for the treatment of HIV
    27.
    发明授权
    Substituted phenylindoles for the treatment of HIV 有权
    用于治疗HIV的取代的苯基吲哚

    公开(公告)号：US07365090B2

    公开(公告)日：2008-04-29

    申请号：US10637949

    申请日：2003-08-07

    申请人： Marino Artico ,  Paolo LaColla ,  Romano Silvestri ,  Adel Moussa ,  Jean-Pierre Sommadossi ,  Richard Storer

    发明人： Marino Artico ,  Paolo LaColla ,  Romano Silvestri ,  Adel Moussa ,  Jean-Pierre Sommadossi ,  Richard Storer

    IPC分类号： A61K31/405 ,  C07D209/14

    CPC分类号： C07D403/04 ,  C07D209/42 ,  C07D403/12

    摘要： This invention is in the area of phenylindoles that are useful for the treatment of HIV infection, and, in particular, phenylindoles that exhibit significant activity against resistant strains of HIV. The phenylindoles have at least two substituents other than hydrogen on the benzo ring of the indole function, preferably at the 4′ and 5′, 5′ and 6′ or the 5′ and 7′ positions, optionally in combination with disubstitution at positions 3″ and 5″ on the phenyl ring of the compound, and carboxamide containing moieties at position-2 on the indole group of the compound. Methyl is a preferred group for substitution on the phenyl ring. Preferred substituents for the benzo ring of the indole function include but are not limited to chlorine, fluorine, bromine, iodine, CF3, methoxy, CN, and NO2.

    摘要翻译： 本发明在可用于治疗HIV感染的苯基吲哚的区域中，特别是对抗HIV抗性菌株显示出显着活性的苯基吲哚。 苯吲哚在吲哚官能团的苯并环上具有至少两个除氢之外的取代基，优选在4'和5'，5'和6'或5'和7'位置，任选地与3位的取代基组合 “和5”，化合物的吲哚基上的位置-2的含羧酰胺的部分。 甲基是在苯环上取代的优选基团。 吲哚官能团的苯并环的优选取代基包括但不限于氯，氟，溴，碘，CF 3，甲氧基，CN和NO 2。