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公开(公告)号:US20190085014A1
公开(公告)日:2019-03-21
申请号:US16149114
申请日:2018-10-01
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
IPC分类号: C07H19/14 , C12Q1/6869 , C07H21/00 , C12Q1/686 , C12Q1/6872 , C12Q1/6876 , C07H19/10 , C12Q1/68 , C12Q1/6874 , C40B40/00
CPC分类号: C12Q1/6869 , C07B2200/11 , C07H19/10 , C07H19/14 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2525/186 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C12Q2565/501 , C40B40/00
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号:US20190031705A1
公开(公告)日:2019-01-31
申请号:US16150185
申请日:2018-10-02
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
IPC分类号: C07H19/14 , C12Q1/6869 , C07H19/10 , C12Q1/6874 , C12Q1/6876 , C12Q1/6872 , C12Q1/68 , C12Q1/686
CPC分类号: C12Q1/6869 , C07B2200/11 , C07H19/10 , C07H19/14 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2525/186 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C12Q2565/501 , C40B40/00
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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公开(公告)号:US10138514B2
公开(公告)日:2018-11-27
申请号:US15444826
申请日:2017-02-28
发明人: Xiaohai Liu , Xiaolin Wu , Geoffrey Paul Smith
IPC分类号: C12Q1/68 , C07H19/073 , C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/173 , C07H19/20 , C12Q1/6876
CPC分类号: C12Q1/6869 , C07H19/073 , C07H19/10 , C07H19/14 , C07H19/173 , C07H19/20 , C12Q1/6876 , Y02P20/55
摘要: Some embodiments described herein relate to modified nucleotide and nucleoside molecules with novel 3′-hydroxy protecting groups. Also provided herein are methods to prepare such modified nucleotide and nucleoside molecules and sequencing by synthesis processes using such modified nucleotide and nucleoside molecules.
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公开(公告)号:US20180201981A1
公开(公告)日:2018-07-19
申请号:US15851014
申请日:2017-12-21
发明人: Nikolai Romanov
IPC分类号: C12Q1/6816 , C12Q1/6876 , C12Q1/6869 , C07D491/052 , C07H21/00 , C07H19/14 , C07H19/10 , C07D491/147 , C09K11/06
CPC分类号: C12Q1/6816 , C07D491/04 , C07D491/052 , C07D491/147 , C07H19/10 , C07H19/14 , C07H21/00 , C09K11/06 , C09K2211/1018 , C12Q1/6869 , C12Q1/6876
摘要: The present application relates to new coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
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公开(公告)号:US20180086785A1
公开(公告)日:2018-03-29
申请号:US15645685
申请日:2017-07-10
IPC分类号: C07H19/16 , C07H19/23 , C07H19/14 , C07D487/04 , C07H19/048 , C07D473/00 , C07D471/04 , C07D405/04 , C07D473/34
CPC分类号: C07H19/16 , C07D405/04 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07H19/048 , C07H19/14 , C07H19/23
摘要: This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
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公开(公告)号:US09777035B2
公开(公告)日:2017-10-03
申请号:US14669398
申请日:2015-03-26
IPC分类号: A61K31/7064 , A61K45/06 , C07H19/12 , C07H19/14 , C07H19/06 , C07D487/04
CPC分类号: C07H19/14 , A61K31/7064 , A61K45/06 , C07D487/04 , C07H19/06 , C07H19/12
摘要: The present invention is directed to 4′-substituted nucleoside derivatives of Formula I and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.
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公开(公告)号:US20170253628A1
公开(公告)日:2017-09-07
申请号:US15599056
申请日:2017-05-18
发明人: John Henry Bougher, III , Ramamurty V S Changalvala , Aaron Leigh Downey , John C. Drach , Ernest Randall Lanier, JR. , Andrew Louis McIver , Bradley David Robertson , Dean Wallace Selleseth , Phiroze Behram Sethna , Leroy Townsend , Roy W. Ware
CPC分类号: C07H19/14 , A61K31/7052 , A61K31/706 , A61K31/7064 , C07D239/70 , C07H19/16
摘要: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
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公开(公告)号:US09725480B2
公开(公告)日:2017-08-08
申请号:US15167917
申请日:2016-05-27
发明人: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
CPC分类号: C07H19/14 , C07B2200/11 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6872 , C12Q1/6874 , C12Q1/6876 , C12Q2525/117 , C12Q2535/101 , C12Q2535/122 , C12Q2563/107 , C40B40/00 , C12Q2565/501 , C12Q2525/186
摘要: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analog after the nucleotide analog is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogs which comprise unique labels attached to the nucleotide analog through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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9.
公开(公告)号:US09689035B2
公开(公告)日:2017-06-27
申请号:US15188283
申请日:2016-06-21
申请人: LASERGEN, INC.
发明人: Brian P. Stupi , Hong Li , Weidong Wu , Megan N. Hersh , David Hertzog , Sidney E. Morris , Michael L. Metzker
IPC分类号: C12Q1/68 , C07H19/073 , C07H19/10 , C07H19/173 , C07H19/20 , C07H19/14 , B01L3/00
CPC分类号: C12Q1/6869 , B01L3/5027 , B01L2300/0654 , B01L2300/168 , C07H19/073 , C07H19/10 , C07H19/14 , C07H19/173 , C07H19/20 , C12Q1/6874 , C12Q1/6883 , C12Q2525/117 , C12Q2600/156 , C12Q2600/16
摘要: The present invention relates generally to 3′-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.
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公开(公告)号:US20170137878A1
公开(公告)日:2017-05-18
申请号:US15343279
申请日:2016-11-04
发明人: Mong Sano Marma , Jerzy Olejnik , IIia Korboukh
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6869 , C07C323/12 , C07C323/60 , C07C2603/18 , C07D207/46 , C07F7/1804 , C07H19/10 , C07H19/14 , C09B1/00 , C09B5/2436 , C09B11/24 , C09B23/083 , C09B23/166 , C12Q1/6811 , C12Q1/6876 , Y02P20/55
摘要: The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.
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