公开(公告)号：US20100112564A1

公开(公告)日：2010-05-06

申请号：US12380103

申请日：2009-02-23

申请人： Liping Zhao ,  Wei Hua ,  Xiaoyan Pang ,  Jia Wei ,  Dazheng Wu

发明人： Liping Zhao ,  Wei Hua ,  Xiaoyan Pang ,  Jia Wei ,  Dazheng Wu

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6888

摘要： precancerous lesions, and subject having precancerous lesions and being treated with an anti-cancer agent; (2) isolating total microbial genomic DNA from the fecal samples to provide total microbial genomic DNA; (3) comparing the total microbial genomic DNA using fingerprint spectrum analysis; (4) identifying key fingerprint bands correlated with the effect of the anti-cancer agent; (5) identifying key microorganisms associated with the key fingerprint bands; (6) designing microbial sequence-specific primers and probes; and (7) determining the quantitative differences of the key microorganisms in fecal samples to identify an indicator microorganism for monitoring the effect of the anti-cancer agent.

摘要翻译： 癌前病变和患有癌前病变并且用抗癌剂治疗的受试者; （2）从粪便样品中分离总微生物基因组DNA以提供总微生物基因组DNA; （3）使用指纹谱分析比较总微生物基因组DNA; （4）识别与抗癌剂作用相关的关键指纹带; （5）识别与关键指纹带相关的关键微生物; （6）设计微生物序列特异性引物和探针; 和（7）确定粪便样品中关键微生物的定量差异，以鉴定用于监测抗癌剂效果的指示剂微生物。

公开(公告)号：US07071660B2

公开(公告)日：2006-07-04

申请号：US11018920

申请日：2004-12-22

申请人： Ming Xu ,  Jinghai Zhou ,  Yuancheng Ren ,  Fred C. Lee ,  Jia Wei

发明人： Ming Xu ,  Jinghai Zhou ,  Yuancheng Ren ,  Fred C. Lee ,  Jia Wei

IPC分类号： H02M3/158

CPC分类号： H02M3/156 ,  H02M2001/0019 ,  H02M2001/0032 ,  H02M2001/007 ,  Y02B70/16

摘要： A two-stage power converter that dynamically adjusts to output current requirements includes a first stage regulator that provides power to a second stage regulator. The first stage can be a buck converter, and the second stage can be a multiple-phase buck converter. The output voltage of the first stage (intermediate bus voltage Vbus) is varied according to the load current to optimize conversion efficiency. To provide maximum efficiency, the Vbus voltage is increased as load current increases. The Vbus voltage provided by the first stage can be varied by duty cycle or operating frequency control. In another embodiment, the switching frequency of the second stage is varied as output current changes so that output current ripple is held constant. In an embodiment employing a multiple-phase buck converter in the second stage, the number of operating phases are varied as output current changes.

摘要翻译： 动态调节输出电流要求的两级功率转换器包括为第二级调节器提供电源的第一级稳压器。 第一级可以是降压转换器，第二级可以是多相降压转换器。 第一级（中间总线电压Vbus）的输出电压根据负载电流而变化，以优化转换效率。 为了提供最大的效率，Vbus电压随着负载电流的增加而增加。 第一级提供的Vbus电压可以通过占空比或工作频率控制来改变。 在另一个实施例中，当输出电流改变时，第二级的开关频率变化，使得输出电流纹波保持恒定。 在第二级采用多相降压转换器的实施例中，随着输出电流的变化，工作阶段的数量变化。

公开(公告)号：US5824786A

公开(公告)日：1998-10-20

申请号：US706215

申请日：1996-08-30

申请人： Chaim Manor ,  Jia Wei ,  Gordon D. MacFarlane

发明人： Chaim Manor ,  Jia Wei ,  Gordon D. MacFarlane

IPC分类号： C07H15/04 ,  C07K16/18 ,  G01N33/53 ,  G01N33/68 ,  A61K31/70

CPC分类号： C07H15/04 ,  C07K16/18 ,  G01N33/5308 ,  G01N33/6887

摘要： Galactosylhydroxylysine is a terminal degradation product of the bone matrix which thus serves as biochemical marker of bone resorption. A method of synthesizing galactosylhydroxylysine is provided. Antibodies against this synthetically prepared galactosylhydroxylysine conjugated to protein carriers were raised to establish methods to measure galactosylhydroxylysine in biological fluids. The antibodies of the invention recognize native galactosylhydroxylysine and are, for example, useful in the measurement of galactosylhydroxylysine as a biochemical marker of bone resorption in biological fluids. Testing of human serum or adolescent urine resulted in dose-dependent increases in signal intensity using the method of the invention.

摘要翻译： 半乳糖羟基赖氨酸是骨基质的终末降解产物，因此用作骨吸收的生物化学标记物。 提供了一种合成半乳糖羟基赖氨酸的方法。 提出了抗这种合成制备的与蛋白质载体结合的半乳糖羟基赖氨酸的抗体，以建立在生物体液中测量半乳糖羟基赖氨酸的方法。 本发明的抗体识别天然半乳糖羟基赖氨酸，并且例如可用于测量半乳糖羟基赖氨酸作为生物流体中骨吸收的生化标志物。 使用本发明的方法，人血清或青少年尿液的测试导致信号强度的剂量依赖性增加。