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公开(公告)号：US5824786A
公开(公告)日：1998-10-20
申请号：US706215
申请日：1996-08-30
申请人： Chaim Manor , Jia Wei , Gordon D. MacFarlane
发明人： Chaim Manor , Jia Wei , Gordon D. MacFarlane
CPC分类号： C07H15/04 , C07K16/18 , G01N33/5308 , G01N33/6887
摘要： Galactosylhydroxylysine is a terminal degradation product of the bone matrix which thus serves as biochemical marker of bone resorption. A method of synthesizing galactosylhydroxylysine is provided. Antibodies against this synthetically prepared galactosylhydroxylysine conjugated to protein carriers were raised to establish methods to measure galactosylhydroxylysine in biological fluids. The antibodies of the invention recognize native galactosylhydroxylysine and are, for example, useful in the measurement of galactosylhydroxylysine as a biochemical marker of bone resorption in biological fluids. Testing of human serum or adolescent urine resulted in dose-dependent increases in signal intensity using the method of the invention.
摘要翻译： 半乳糖羟基赖氨酸是骨基质的终末降解产物，因此用作骨吸收的生物化学标记物。 提供了一种合成半乳糖羟基赖氨酸的方法。 提出了抗这种合成制备的与蛋白质载体结合的半乳糖羟基赖氨酸的抗体，以建立在生物体液中测量半乳糖羟基赖氨酸的方法。 本发明的抗体识别天然半乳糖羟基赖氨酸，并且例如可用于测量半乳糖羟基赖氨酸作为生物流体中骨吸收的生化标志物。 使用本发明的方法，人血清或青少年尿液的测试导致信号强度的剂量依赖性增加。
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2.发明授权Living coordinative chain transfer polymerization with dynamic counterion exchange 有权活性配位链转移聚合与动态抗衡离子交换公开(公告)号：US09175103B2
公开(公告)日：2015-11-03
申请号：US13703212
申请日：2011-06-10
申请人： Lawrence R. Sita , Jia Wei , Wei Zhang
发明人： Lawrence R. Sita , Jia Wei , Wei Zhang
IPC分类号： C08F4/643 , C08F4/6592 , C08F210/00 , C08F210/16 , C08F4/659
CPC分类号： C08F4/643 , C08F4/65908 , C08F4/6592 , C08F210/16 , C08F2410/01 , C08F2420/01 , C08F2420/02 , C08F210/14 , C08F2500/03 , C08F2/38
摘要： Disclosed is a method of producing a polyolefin composition comprising contacting a metal alkyl and a first olefin monomer, then adding a first co-catalyst, a second co-catalyst, a pre-catalyst, and a second olefin monomer. The method allows for the production of a series of copolymers with tunable incorporation ratios of the first olefin monomer. The method also allows for the production of polyolefins of low molecular weights and narrow molecular weight distributions.
摘要翻译： 公开了一种生产聚烯烃组合物的方法，包括使烷基金属和第一烯烃单体接触，然后加入第一助催化剂，第二助催化剂，预催化剂和第二烯烃单体。 该方法允许制备一系列具有可调谐的第一烯烃单体掺入比的共聚物。 该方法还允许生产低分子量和窄分子量分布的聚烯烃。
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3.发明授权Methods for detecting therapeutic effects of anti-cancer drugs by monitoring changes in gut flora 有权通过监测肠道菌群变化来检测抗癌药物的治疗效果的方法公开(公告)号：US08097417B2
公开(公告)日：2012-01-17
申请号：US12380103
申请日：2009-02-23
申请人： Liping Zhao , Wei Hua , Xiaoyan Pang , Jia Wei , Dazheng Wu
发明人： Liping Zhao , Wei Hua , Xiaoyan Pang , Jia Wei , Dazheng Wu
CPC分类号： C12Q1/6886 , C12Q1/6888
摘要： Non-invasive methods for monitoring the effect of an agent for treating colorectal cancer, comprising (1) collecting fecal samples from healthy subjects, subjects having precancerous lesions, and subject having precancerous lesions and being treated with an anti-cancer agent; (2) isolating total microbial genomic DNA from the fecal samples to provide total microbial genomic DNA; (3) comparing the total microbial genomic DNA using fingerprint spectrum analysis; (4) identifying key fingerprint bands correlated with the effect of the anti-cancer agent; (5) identifying key microorganisms associated with the key fingerprint bands; (6) designing microbial sequence-specific primers and probes; and (7) determining the quantitative differences of the key microorganisms in fecal samples to identify an indicator microorganism for monitoring the effect of the anti-cancer agent.
摘要翻译： 用于监测药物治疗结肠直肠癌的效果的非侵入性方法，包括（1）从健康受试者收集粪便样品，患有癌前病变的受试者和患有癌前病变的受试者并用抗癌剂治疗; （2）从粪便样品中分离总微生物基因组DNA以提供总微生物基因组DNA; （3）使用指纹谱分析比较总微生物基因组DNA; （4）识别与抗癌剂作用相关的关键指纹带; （5）识别与关键指纹带相关的关键微生物; （6）设计微生物序列特异性引物和探针; 和（7）确定粪便样品中关键微生物的定量差异，以鉴定用于监测抗癌剂效果的指示剂微生物。
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4.发明授权Auxiliary turn-on mechanism for reducing conduction loss in body-diode of low side MOSFET of coupled-inductor DC-DC converter 失效辅助导通机制，用于降低耦合电感器DC-DC转换器低侧MOSFET体二极管的导通损耗公开(公告)号：US07443146B2
公开(公告)日：2008-10-28
申请号：US11519516
申请日：2006-09-12
CPC分类号： H02M3/1584 , H02M2001/0064
摘要： Conduction loss in the body-diode of a low side MOSFET of a power switching stage of one phase of a coupled-inductor, multi-phase DC-DC converter circuit, associated with current flow in the output inductor of that one phase that is induced by current flow in a mutually coupled output inductor of another phase, during normal switching of that other stage, is effectively prevented by applying auxiliary MOSFET turn-on signals, that coincide with the duration of the induced current, to that low side MOSFET, so that the induced current will flow through the turned-on low side MOSFET itself, thereby by-passing its body-diode.
摘要翻译： 耦合电感器，多相DC-DC转换器电路的一相的功率开关级的低侧MOSFET的体二极管中的导通损耗与引起的该相的输出电感器中的电流相关联 通过在该另一级的正常切换期间在另一相的相互耦合的输出电感器中的电流流动，通过将与感应电流的持续时间相一致的辅助MOSFET导通信号施加到该低侧MOSFET而被有效地防止，因此 感应电流将流过导通的低端MOSFET本身，从而旁路其体二极管。
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公开(公告)号：US09755520B2
公开(公告)日：2017-09-05
申请号：US12651985
申请日：2010-01-04
CPC分类号： H02M3/1584 , H02M3/1588 , H02M2001/0064 , Y02B70/1466
摘要： An embodiment of a power-supply controller includes first and second circuits. The first circuit is operable to cause a first current to flow through a first phase of a power supply. And the second circuit is operable to cause the second phase of the power supply to operate in a reduced-power-dissipation mode for at least a portion of a time period during which a second current magnetically induced by the first current flows through the second phase.
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6.发明授权公开(公告)号：US08570009B2
公开(公告)日：2013-10-29
申请号：US12136014
申请日：2008-06-09
申请人： Jia Wei , Michael Jason Houston
发明人： Jia Wei , Michael Jason Houston
CPC分类号： G05F3/04 , H02M3/156 , H02M3/1584 , H02M7/003
摘要： An embodiment of a power supply includes an input node that receives an input voltage, an output node on which a regulated output voltage is provided, an odd number of magnetically coupled phase paths each coupled between the input and output nodes, and a first magnetically uncoupled phase path coupled between the input and output nodes. Such a power supply can improve its efficiency by activating different combinations of the coupled and uncoupled phase paths depending on the load conditions. For example, the power supply may activate only an uncoupled phase path during light-load conditions, may activate only coupled phase paths during moderate-load conditions, and may activate both coupled and uncoupled phase paths during heavy-load conditions and during a step-up load transient.
摘要翻译： 电源的实施例包括接收输入电压的输入节点，其上提供调节输出电压的输出节点，每个耦合在输入和输出节点之间的奇数个磁耦合相位路径，以及第一磁耦合 相位路径耦合在输入和输出节点之间。 这样的电源可以通过根据负载条件激活耦合和非耦合相位路径的不同组合来提高其效率。 例如，在轻负载状态期间，电源可以仅激活非耦合相位路径，在中等负载状态下仅激活耦合的相位路径，并且可以在重负载状态期间和在步进电压期间激活耦合和非耦合相位路径， up负载瞬变。
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公开(公告)号：US08362752B2
公开(公告)日：2013-01-29
申请号：US12136014
申请日：2008-06-09
申请人： Jia Wei , Michael Jason Houston
发明人： Jia Wei , Michael Jason Houston
摘要： An embodiment of a power supply includes an input node that receives an input voltage, an output node on which a regulated output voltage is provided, an odd number of magnetically coupled phase paths each coupled between the input and output nodes, and a first magnetically uncoupled phase path coupled between the input and output nodes. Such a power supply can improve its efficiency by activating different combinations of the coupled and uncoupled phase paths depending on the load conditions. For example, the power supply may activate only an uncoupled phase path during light-load conditions, may activate only coupled phase paths during moderate-load conditions, and may activate both coupled and uncoupled phase paths during heavy-load conditions and during a step-up load transient.
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公开(公告)号：US08179116B2
公开(公告)日：2012-05-15
申请号：US12136023
申请日：2008-06-09
申请人： Jia Wei , Michael Jason Houston
发明人： Jia Wei , Michael Jason Houston
IPC分类号： H01F29/14
CPC分类号： G05F3/04 , H02M3/156 , H02M3/1584 , H02M7/003
摘要： An embodiment of an inductor assembly includes a core, a first conductor, and a second conductor. The core includes first and second members, a first group of one or more forms extending between the members, a second group of one or more forms extending between the members, and an isolating region that magnetically isolates the first group of forms from the second group of forms. The first conductor is wound about a first one of the forms in the first group, and the second conductor is wound about a second one of the forms in the second group. Such an inductor assembly may allow both coupled and uncoupled inductors to be disposed on a common core, thus potentially reducing the cost and size of the inductors as compared to the coupled inductors being disposed on one core and the uncoupled inductors being disposed on another core.
摘要翻译： 电感器组件的实施例包括芯，第一导体和第二导体。 芯包括第一和第二构件，在构件之间延伸的一种或多种形式的第一组，在构件之间延伸的一种或多种形式的第二组，以及将第一组形式与第二组磁隔离的隔离区 的形式。 第一导体围绕第一组中的第一形式缠绕，并且第二导体围绕第二组中的第二形式缠绕。 这样的电感器组件可以允许耦合和非耦合的电感器被布置在公共芯上，因此与设置在一个芯上的耦合电感器和未耦合的电感器设置在另一个芯上相比，潜在地降低了电感器的成本和尺寸。
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公开(公告)号：US20080067990A1
公开(公告)日：2008-03-20
申请号：US11903185
申请日：2007-09-19
申请人： Jia Wei
发明人： Jia Wei
CPC分类号： H01F27/2804 , H01F38/00 , H01F41/046 , H01F2027/2814 , H02M3/1584
摘要： An embodiment of a coupled-inductor structure includes a core and a conductor. The core includes first and second members, and spaced-apart forms extending between the members, and the conductor is partially wound about one of the forms. Because the conductor is only partially wound about a form of the core, the conductor may be shorter, wider, or both shorter and wider, and thus may have a smaller resistance, than a conductor that forms a winding of a conventional coupled-inductor structure. Consequently, a coupled-inductor structure incorporating one or more of such partially wound conductors may consume less power and generate less heat than a conventional coupled-inductor structure for given winding currents and voltages.
摘要翻译： 耦合电感器结构的实施例包括芯和导体。 芯包括第一和第二构件，并且在构件之间延伸的间隔开的形式，并且导体围绕其中一个形式被部分地缠绕。 由于导体仅部分地围绕芯的形式缠绕，导体可以比形成常规耦合电感器结构的绕组的导体更短，更宽或更短和更宽，因此可以具有更小的电阻 。 因此，对于给定的绕组电流和电压，结合一个或多个这种部分缠绕的导体的耦合电感器结构可以消耗较少的功率并且比常规耦合电感器结构产生的热量更少。
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10.发明授权公开(公告)号：US09416069B2
公开(公告)日：2016-08-16
申请号：US13520389
申请日：2011-01-04
申请人： Lawrence R. Sita , Jia Wei
发明人： Lawrence R. Sita , Jia Wei
CPC分类号： C07C2/30 , C08F10/00 , C08F2410/01 , C08F2420/04 , C08F110/06 , C08F4/6592 , C08F4/64044 , C08F2/38 , C08F210/06 , C08F210/14 , C08F2500/02
摘要： Disclosed is a method of producing a polyolefin composition comprising contacting a metallocene pre-catalyst, a co-catalyst, a primary surrogate, and a secondary surrogate; adding a first olefin monomer; and polymerizing the first monomer for a time sufficient to form the polyolefin. Also disclosed is a method of producing a block polyolefin composition comprising contacting a metallocene pre-catalyst, a co-catalyst, a primary surrogate, and a secondary surrogate; polymerizing the first monomer for a time sufficient to form the polyolefin; adding a second monomer; and polymerizing the second olefin monomer for a time sufficient to form said block polyolefin composition. The method allows for the production of polyolefins of low molecular weights and narrow molecular weight distributions.
摘要翻译： 公开了一种生产聚烯烃组合物的方法，包括使茂金属预催化剂，助催化剂，主代替物和次级代理物接触; 加入第一种烯烃单体; 并使第一单体聚合足以形成聚烯烃的时间。 还公开了一种制备嵌段聚烯烃组合物的方法，包括使茂金属预催化剂，助催化剂，主代理和次级代理接触; 使第一单体聚合足以形成聚烯烃的时间; 加入第二单体; 并使第二烯烃单体聚合足以形成所述嵌段聚烯烃组合物的时间。 该方法允许生产低分子量和窄分子量分布的聚烯烃。
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