-
公开(公告)号：US09745373B2
公开(公告)日：2017-08-29
申请号：US13476465
申请日：2012-05-21
申请人： Brian Robert Kovacevich , Leon F. Garcia-Martinez , Katie Olson , Benjamin H. Dutzar , Jens J. Billgren , John A. Latham , Danielle M. Mitchell , Patricia Dianne Mcneill , Nicole M. Janson , Maria-Cristina Loomis
发明人： Brian Robert Kovacevich , Leon F. Garcia-Martinez , Katie Olson , Benjamin H. Dutzar , Jens J. Billgren , John A. Latham , Danielle M. Mitchell , Patricia Dianne Mcneill , Nicole M. Janson , Maria-Cristina Loomis
CPC分类号： C07K16/18 , A61K31/485 , A61K39/3955 , A61K49/00 , A61K2039/505 , C07K16/26 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.
-
公开(公告)号：US20120294797A1
公开(公告)日：2012-11-22
申请号：US13476465
申请日：2012-05-21
申请人： Brian Robert Kovacevich , Leon F. Garcia-Martinez , Katie Olson , Benjamin H. Dutzar , Jens J. Billgren , John A. Latham , Danielle M. Mitchell , Patricia Dianne Mcneill , Nicole M. Janson , Maria-Cristina Loomis
发明人： Brian Robert Kovacevich , Leon F. Garcia-Martinez , Katie Olson , Benjamin H. Dutzar , Jens J. Billgren , John A. Latham , Danielle M. Mitchell , Patricia Dianne Mcneill , Nicole M. Janson , Maria-Cristina Loomis
IPC分类号： C07K16/18 , C12N15/63 , C12N1/19 , A61K39/395 , A61K49/00 , A61K51/00 , C12Q1/68 , C12N5/10 , C12N1/15 , C12N1/21 , A61P25/06 , A61P3/00 , A61P35/00 , A61P25/00 , A61P29/00 , A61P19/08 , A61P1/16 , A61P13/12 , A61P13/00 , A61P3/10 , A61P37/00 , A61P9/00 , A61P19/02 , A61P11/00 , A61P11/06 , A61P25/36 , A61P15/00 , A61P17/00 , A61P17/06 , A61P25/08 , A61P25/28 , A61P17/04 , A61P1/00 , A61P37/08 , A61P31/00 , C12N15/13
CPC分类号： C07K16/18 , A61K31/485 , A61K39/3955 , A61K49/00 , A61K2039/505 , C07K16/26 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.
摘要翻译： 本发明涉及对CGRP具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还考虑了抗CGRP抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗CGRP抗体及其结合片段的方法。 本发明的实施方案还涉及抗CGRP抗体及其结合片段用于诊断，评估和治疗与CGRP相关的疾病和病症的用途。
-
搜索结果
22 条记录 (耗时 0.04 秒)
