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    ANTIBODIES TO IL-6 AND USE THEREOF
    4.
    发明申请
    ANTIBODIES TO IL-6 AND USE THEREOF 有权
    抗IL-6的抗体及其用途

    公开(公告)号：US20130034554A1

    公开(公告)日：2013-02-07

    申请号：US13511865

    申请日：2010-11-24

    申请人： Leon F. Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Benjamin H. Dutzar ,  John A. Latham ,  Brian Robert Kovacevich ,  Jeffrey T.L. Smith ,  Mark Litton ,  Randall Schatzman

    发明人： Leon F. Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Benjamin H. Dutzar ,  John A. Latham ,  Brian Robert Kovacevich ,  Jeffrey T.L. Smith ,  Mark Litton ,  Randall Schatzman

    IPC分类号： A61K39/395 ,  A61P37/06 ,  C12N5/071 ,  A61P35/00 ,  A61P1/04 ,  A61P35/04 ,  A61P29/00 ,  A61P35/02

    CPC分类号： A61K51/1033 ,  A61K49/0004 ,  A61K49/0058 ,  A61K2039/505 ,  C07K16/248 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6863 ,  Y02A50/412 ,  Y02A50/58

    摘要： The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others. Additional preferred embodiments of the subject invention relate to therapeutic compositions and methods treating or preventing rheumatoid arthritis, especially subcutaneous and intravenous formulations and dosage regimens using IL-6 antagonists according to the invention, as well as methods for preventing or treating GVHD or leukemia relapse in subjects receiving transplanted cells, tissue or organs, use thereof in the treatment or prevention of mucositis, and use thereof to potentiate the cytotoxic, apoptotic, and anti-metastatic or anti-invasive effects of chemotherapeutics and radiation on cancers, especially cancers that have developed a resistance to radiation or chemotherapy, such as an EGFR inhibitor.

    摘要翻译： 本发明涉及使用IL-6拮抗剂例如Ab1抗体或对IL-6具有结合特异性的抗体片段来预防或治疗疾病或改善有需要的患者的生存能力或生活质量的治疗方法。 在优选实施方案中，这些患者将包括显示（或有发展风险）升高的血清C-反应蛋白水平，降低的血清白蛋白水平，升高的D-二聚体或其他凝血级联相关蛋白，恶病质，发热，虚弱和 /或治疗前的疲劳。 主题疗法还可以包括施用其它活性物质，例如化学治疗剂，抗凝血剂，他汀类药物等。 本发明的另外的优选实施方案涉及使用根据本发明的IL-6拮抗剂治疗或预防类风湿性关节炎，特别是皮下和静脉内制剂和剂量方案的治疗组合物和方法，以及用于预防或治疗GVHD或白血病复发的方法 接受移植细胞，组织或器官的受试者在治疗或预防粘膜炎中的用途及其用途来增强化学治疗剂和辐射对癌症尤其是已经发展的癌症的细胞毒性，凋亡和抗转移或抗侵袭作用 抗辐射或化学疗法，如EGFR抑制剂。

    Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
    6.
    发明授权
    Use of anti-IL-6 antibodies having specific binding properties to treat cachexia 有权
    使用具有特异性结合特性的抗IL-6抗体治疗恶病质

    公开(公告)号：US08178101B2

    公开(公告)日：2012-05-15

    申请号：US12391717

    申请日：2009-02-24

    申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

    发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

    IPC分类号： A61K39/395 ,  C12P21/08 ,  C07K16/24

    CPC分类号： C07K16/248 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76

    摘要： The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

    摘要翻译： 本发明涉及对IL-6具有结合特异性的抗体及其片段和人源化形式。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还涉及抗IL-6抗体及其与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗IL-6抗体及其结合片段的方法。 本发明的实施方案还涉及抗IL-6抗体及其结合片段用于诊断，评估和治疗与IL-6相关的疾病和病症的用途。 这些抗体可以结合可溶性IL-6，细胞表面表达的IL-6，IL-6 / IL-6R中的至少一种和/或阻止IL-6和IL-6R的结合，IL-6 / IL -6R和gp130，或者形成IL-6 / IL-6R / gp130多聚体，从而抑制与前述任何相关的生物学作用。

    Antibodies to IL-6 and use thereof
    7.
    发明申请
    Antibodies to IL-6 and use thereof 审中-公开
    IL-6抗体及其用途

    公开(公告)号：US20100290993A1

    公开(公告)日：2010-11-18

    申请号：US12601295

    申请日：2008-05-21

    申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  John Latham ,  Brian Kovacevich ,  Jeffrey T.L. Smith

    发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  John Latham ,  Brian Kovacevich ,  Jeffrey T.L. Smith

    IPC分类号： A61K49/00 ,  A61K39/395 ,  G01N33/53 ,  C12N5/10 ,  C12N1/19 ,  C12N15/63 ,  G01N33/566 ,  C07K16/24 ,  C07H21/04 ,  A61P19/02 ,  A61P17/06 ,  A61P37/06 ,  A61P19/10 ,  A61P35/00 ,  A61P35/04 ,  A61P3/10 ,  A61P3/04 ,  A61P11/06 ,  A61P25/28 ,  A61P7/06 ,  A61P25/24 ,  A61P7/02 ,  A61P29/00

    摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

    摘要翻译： 本发明涉及对IL-6具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还涉及抗IL-6抗体及其与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗IL-6抗体及其结合片段的方法。 本发明的实施方案还涉及抗IL-6抗体及其结合片段用于诊断，评估和治疗与IL-6相关的疾病和病症的用途。 这些抗体可以结合可溶性IL-6，细胞表面表达的IL-6，IL-6 / IL-6R中的至少一种和/或阻止IL-6和IL-6R的结合，IL-6 / IL -6R和gp130，或者形成IL-6 / IL-6R / gp130多聚体，从而抑制与前述任何相关的生物学作用。

    Antibodies to IL-6 and use thereof
    10.
    发明授权
    Antibodies to IL-6 and use thereof 有权
    IL-6抗体及其用途

    公开(公告)号：US07935340B2

    公开(公告)日：2011-05-03

    申请号：US12153612

    申请日：2008-05-21

    申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

    发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

    IPC分类号： A61K39/395 ,  C07K16/24 ,  C12P21/08

    CPC分类号： C07K16/248 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/76 ,  C07K2317/94

    摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

    摘要翻译： 本发明涉及对IL-6具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还涉及抗IL-6抗体及其与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗IL-6抗体及其结合片段的方法。 本发明的实施方案还涉及抗IL-6抗体及其结合片段用于诊断，评估和治疗与IL-6相关的疾病和病症的用途。 这些抗体可以结合可溶性IL-6，细胞表面表达的IL-6，IL-6 / IL-6R中的至少一种和/或阻止IL-6和IL-6R的结合，IL-6 / IL -6R和gp130，或者形成IL-6 / IL-6R / gp130多聚体，从而抑制与前述任何相关的生物学作用。