公开(公告)号：US08519602B2

公开(公告)日：2013-08-27

申请号：US13006842

申请日：2011-01-14

Applicant: Kenji Shibata ,  Kazufumi Suenaga ,  Akira Nomoto ,  Kazutoshi Watanabe

Inventor： Kenji Shibata ,  Kazufumi Suenaga ,  Akira Nomoto ,  Kazutoshi Watanabe

IPC: H01L41/187

CPC classification number: H01L41/094 ,  H01L41/1873 ,  H03H9/02031

Abstract: To provide a piezoelectric thin film on a substrate, having an alkali-niobium oxide-based perovskite structure expressed by a composition formula (K1-xNax)yNbO3, wherein the composition ratio x of the piezoelectric thin film expressed by (K1-xNax)yNbO3 is in a range of 0.4≦x≦0.7, and a half width of a rocking curve of (001) plane by X-ray diffraction measurement is in a range of 0.5° or more and 2.5° or less.

Abstract translation: 为了在基板上提供具有由组成式（K1-xNax）yNbO3表示的碱金属氧化铌基钙钛矿结构的压电薄膜，其中由（K1-xNax）yNbO3表示的压电薄膜的组成比x 在0.4 @ x @ 0.7的范围内，并且通过X射线衍射测量的（001）面的摇摆曲线的半宽度在0.5°以上且2.5°以下的范围内。

公开(公告)号：US08518939B2

公开(公告)日：2013-08-27

申请号：US13467302

申请日：2012-05-09

Applicant: Kenji Fukunaga ,  Kazutoshi Watanabe ,  Pascal Barneoud ,  Jesus Benavides ,  Jeremy Pratt

Inventor： Kenji Fukunaga ,  Kazutoshi Watanabe ,  Pascal Barneoud ,  Jesus Benavides ,  Jeremy Pratt

IPC: A61K31/535 ,  C07D413/00

CPC classification number: C07D413/14

Abstract: A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).

Abstract translation: 由式（I）表示的化合物或其药学上可接受的盐：用于预防和/或治疗由tau蛋白激酶1的异常活性（例如神经变性疾病（例如阿尔茨海默病））引起的疾病。

公开(公告)号：US20120304429A1

公开(公告)日：2012-12-06

申请号：US13488230

申请日：2012-06-04

Applicant: Fumimasa HORIKIRI ,  Kenji Shibata ,  Kazufumi Suenaga ,  Kazutoshi Watanabe ,  Akira Nomoto

Inventor： Fumimasa HORIKIRI ,  Kenji Shibata ,  Kazufumi Suenaga ,  Kazutoshi Watanabe ,  Akira Nomoto

IPC: H01L41/22

CPC classification number: H01L41/0815 ,  H01L41/1873 ,  H01L41/316 ,  H01L41/332 ,  Y10T29/42

Abstract: A manufacturing method of a piezoelectric film element includes forming a lower electrode on a substrate, forming a piezoelectric film including a lead-free alkali niobate based compound having a perovskite structure on the lower electrode, forming a mask pattern on the piezoelectric film, dry-etching the piezoelectric film via the mask pattern, removing the mask pattern after the dry etching, and heat-treating the piezoelectric film in an oxidizing atmosphere. A manufacturing method of a piezoelectric device includes forming an upper electrode on the piezoelectric film of the piezoelectric film element formed by the manufacturing method of the piezoelectric film element, and connecting an electric voltage applying means or an electric voltage detecting means to the lower electrode and the upper electrode.

Abstract translation: 压电薄膜元件的制造方法包括在基板上形成下电极，在下电极上形成包含具有钙钛矿结构的无铅碱铌酸酯系化合物的压电膜，在压电膜上形成掩模图案， 通过掩模图案蚀刻压电膜，在干蚀刻之后去除掩模图案，并在氧化气氛中对压电膜进行热处理。 压电器件的制造方法包括：在压电膜元件的制造方法形成的压电膜元件的压电膜上形成上电极，将电压施加单元或电压检测单元连接到下电极， 上电极。

公开(公告)号：US20120208797A1

公开(公告)日：2012-08-16

申请号：US13389512

申请日：2010-08-11

Applicant: Kazuki Nakayama ,  Daiki Sakai ,  Kazutoshi Watanabe ,  Toshiyuki Kohara ,  Keiichi Aritomo

Inventor： Kazuki Nakayama ,  Daiki Sakai ,  Kazutoshi Watanabe ,  Toshiyuki Kohara ,  Keiichi Aritomo

IPC: A61K31/55 ,  A61K31/506 ,  C07D413/14 ,  A61K31/5377 ,  C07D265/14 ,  A61K31/536 ,  A61P25/28 ,  A61P25/00 ,  A61P25/16 ,  A61P3/10 ,  A61P3/04 ,  A61P25/24 ,  A61P25/18 ,  A61P35/00 ,  A61P35/02 ,  A61P33/06 ,  C07D403/14

CPC classification number: C07D401/12 ,  C07D233/76 ,  C07D401/14 ,  C07D407/12 ,  C07D409/14 ,  C07D413/14

Abstract: A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom or C—X; X represents hydrogen atom or fluorine atom; R1 is hydrogen atom or a C1-C3 alkyl group; L represents single bond or a C1-C6 alkylene group which may be substituted; Y represents single bond, sulfur atom, oxygen atom, NH, or the like; R2 represents hydrogen atom or a cyclic group which may be substituted, which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).

Abstract translation: 由式（I）表示的化合物或其药学上可接受的盐：其中Z表示氮原子或C-X; X表示氢原子或氟原子; R1是氢原子或C1-C3烷基; L表示单键或可以被取代的C1-C6亚烷基; Y表示单键，硫原子，氧原子，NH等; R2代表氢原子或可被取代的环状基团，其用于预防和/或治疗由tau蛋白激酶1的异常活性如神经变性疾病（例如阿尔茨海默病）引起的疾病。

公开(公告)号：US08106045B2

公开(公告)日：2012-01-31

申请号：US11573476

申请日：2005-09-09

Applicant: Kazutoshi Watanabe ,  Fumiaki Uehara ,  Shinsuke Hiki ,  Toshiyuki Kohara ,  Kenji Fukunaga ,  Satoshi Yokoshima

Inventor： Kazutoshi Watanabe ,  Fumiaki Uehara ,  Shinsuke Hiki ,  Toshiyuki Kohara ,  Kenji Fukunaga ,  Satoshi Yokoshima

IPC: A61K31/535 ,  A61K31/54 ,  C07D413/00 ,  C07D413/14

CPC classification number: C07D413/14

Abstract: A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein X represents CH or N; represents a C1-C12 alkyl; R2 represents a hydrogen atom, or the like; R′ represents a C1-C6 alkyl or the like; q represents 0 or an integer of 1 to 7; Y represents a C1-C6 alkyl or the like; p represents 0 or an integer of 1 to 5; R represents a 2,3-dihydroindolyl or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

Abstract translation: 由式（I）表示的化合物，其光学活性异构体或其药学上可接受的盐：其中X表示CH或N; 表示C1-C12烷基; R2表示氢原子等; R'表示C1-C6烷基等; q表示0或1〜7的整数， Y表示C1-C6烷基等; p表示0或1〜5的整数。 R表示2,3-二氢吲哚基等，其用于预防和/或治疗由tau蛋白激酶1多动症如神经变性疾病（例如阿尔茨海默病）引起的疾病。

公开(公告)号：US07997124B2

公开(公告)日：2011-08-16

申请号：US11879878

申请日：2007-07-19

Applicant: Yoshiteru Shikakura ,  Kazutoshi Watanabe

Inventor： Yoshiteru Shikakura ,  Kazutoshi Watanabe

IPC: G01B5/28

CPC classification number: G01Q30/04 ,  G01Q10/065

Abstract: A scanning probe microscope has a cantilever mounted to undergo oscillation movement over a surface of a sample. The cantilever has a probe on a distal end thereof. A Z-axis controlling amount calculating mechanism calculates a controlling amount for keeping constant an oscillation amount of the cantilever. A Z-axis driving mechanism drives in a Z direction the cantilever or the sample in accordance with the controlling amount from the Z-axis controlling amount calculating mechanism. A driving range limiting device limits a driving range of the Z-axis driving mechanism. A driving range setting device optionally sets the driving range of the Z-axis driving mechanism.

Abstract translation: 扫描探针显微镜具有悬臂安装以在样品的表面上经历振荡运动。 悬臂在其远端具有探针。 Z轴控制量计算机构计算用于保持悬臂的振荡量恒定的控制量。 Z轴驱动机构根据来自Z轴控制量计算机构的控制量沿Z方向驱动悬臂或样本。 驱动范围限制装置限制了Z轴驱动机构的驱动范围。 驱动范围设定装置可选地设定Z轴驱动机构的驱动范围。

公开(公告)号：US20090239864A1

公开(公告)日：2009-09-24

申请号：US11576062

申请日：2005-09-29

Applicant: Kazutoshi Watanabe ,  Kenji Fukunaga ,  Toshiyuki Kohara ,  Fumiaki Uehara ,  Shinsuke Hiki ,  Satoshi Yokoshima

Inventor： Kazutoshi Watanabe ,  Kenji Fukunaga ,  Toshiyuki Kohara ,  Fumiaki Uehara ,  Shinsuke Hiki ,  Satoshi Yokoshima

IPC: A61K31/5377 ,  C07D413/14 ,  A61P25/28 ,  A61P27/06 ,  A61P25/16 ,  A61P3/10

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

Abstract: A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein R1 represents a C1-C12 alkyl; R2 represents a hydrogen atom or the like; R3 represents a halogen or the like; q represents an integer of 1 to 7; R4 represents a halogen or the like; p represents 0 or an integer of 1 to 5; R5 represents a C6-C10 aryl, a heterocycle or the like; and X represents oxygen, NH, or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

Abstract translation: 由式（I）表示的化合物，其光学活性异构体或其药学上可接受的盐：其中R1表示C1-C12烷基; R2表示氢原子等; R3表示卤素等; q表示1〜7的整数， R4表示卤素等; p表示0或1〜5的整数， R5表示C6-C10芳基，杂环等; X代表氧，NH等，其用于预防和/或治疗由tau蛋白激酶1多动症如神经变性疾病（例如阿尔茨海默病）引起的疾病。

公开(公告)号：US07504411B2

公开(公告)日：2009-03-17

申请号：US10550299

申请日：2004-03-26

Applicant: Kazutoshi Watanabe ,  Fumiaki Uehara ,  Shinsuke Hiki ,  Satoshi Yokoshima ,  Yoshihiro Usui ,  Masahiro Okuyama ,  Aya Shoda ,  Keiichi Aritomo ,  Toshiyuki Kohara ,  Kenji Fukunaga

Inventor： Kazutoshi Watanabe ,  Fumiaki Uehara ,  Shinsuke Hiki ,  Satoshi Yokoshima ,  Yoshihiro Usui ,  Masahiro Okuyama ,  Aya Shoda ,  Keiichi Aritomo ,  Toshiyuki Kohara ,  Kenji Fukunaga

IPC: C07D401/14 ,  C07D403/14 ,  A61K31/496 ,  A61K31/506 ,  A61P3/10 ,  A61P25/28

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof; useful for prventive and/or therapeutic treatment of diseass such as neurodegenerative diseases (e.g. Alzheimer disease); wherein Q represents CH or nitrogen atom; R represents a C1-C12 alkyl group; the ring of Formula (I): represents piperazine ring or piperidine ring; each X independently represents a C1-C8 alkyl group, an optionally partially hydrogenated C6-C10 aryl ring, an indan ring or the like; m represents an integer of 1 to 3; each independently represents a halogen atom, a hydroxy group, a cyano group, a C1-C6 alkyl group or the like; n represents an integer of 0 to 8; when X and Y or two Y groups are attached on the same carbon atom, they may combine to each other to form a C2-C6 alkylene group.

Abstract translation: 具有由式（I）表示的tau蛋白激酶1抑制活性的嘧啶酮衍生物或其盐或其溶剂合物或其水合物; 可用于疾病的预防和/或治疗性治疗，例如神经变性疾病（例如阿尔茨海默病）; 其中Q表示CH或氮原子; R代表C1-C12烷基; 式（I）的环表示哌嗪环或哌啶环; 每个X独立地表示C1-C8烷基，任选部分氢化的C 6 -C 10芳基环，茚满环等; m表示1〜3的整数， 各自独立地表示卤素原子，羟基，氰基，C1-C6烷基等; n表示0〜8的整数， 当X和Y或两个Y基团连接在同一个碳原子上时，它们可以彼此结合形成C 2 -C 6亚烷基。

公开(公告)号：US07414612B2

公开(公告)日：2008-08-19

申请号：US10890864

申请日：2004-07-14

Applicant: Hirofumi Niitsuma ,  Kazutoshi Watanabe ,  Junichi Inamuara ,  Isao Sato

Inventor： Hirofumi Niitsuma ,  Kazutoshi Watanabe ,  Junichi Inamuara ,  Isao Sato

IPC: G06F3/02 ,  G06G5/00 ,  H01H3/12 ,  H01H1/10

CPC classification number: G06F3/0362 ,  A63F13/06 ,  A63F13/218 ,  A63F13/24 ,  A63F2300/1043 ,  A63F2300/1056

Abstract: In an analog input device, a rubber member is provided between a key top and a movable electrode of an analog-quantity generating unit. A dead zone can be removed or reduced by forming a bottom portion of the rubber member of a flat or curved face. Furthermore, since first round surfaces are connected to an outer side face, the linearity of the input (e.g., a load)-output (voltage) characteristic can be enhanced.

Abstract translation: 在模拟输入装置中，橡胶构件设置在模拟量产生单元的键顶和可动电极之间。 通过形成平坦或曲面的橡胶构件的底部部分可以去除或减少死区。 此外，由于第一圆形表面连接到外侧面，因此可以提高输入（例如，负载） - 输出（电压）特性的线性。

公开(公告)号：US20080049223A1

公开(公告)日：2008-02-28

申请号：US11840549

申请日：2007-08-17

Applicant: Masato Iyoki ,  Hiroyoshi Yamamoto ,  Kazutoshi Watanabe

Inventor： Masato Iyoki ,  Hiroyoshi Yamamoto ,  Kazutoshi Watanabe

IPC: G01J4/00 ,  G01B11/14 ,  G01N21/47

CPC classification number: G01Q20/02

Abstract: The optical displacement-detecting mechanism has: a light source for irradiating a target for measurement with light; a light source-driving circuit for driving the light source; an optical detector made from a semiconductor for receiving light after the irradiation of the target for measurement by the light source and converting the light into an electric signal thereby to detect an intensity of light; and an amplifier including a current-voltage conversion circuit for performing current-to-voltage conversion on a detection signal of the optical detector with a predetermined amplification factor. In the optical displacement-detecting mechanism, a light source having a spectrum half width of 10 nm or larger is used, whereby the light source can be driven with an output power of 2 mW or larger without generating mode hop noise and optical feedback noise.

Abstract translation: 光学位移检测机构具有：用光照射被测物的光源; 用于驱动光源的光源驱动电路; 由半导体制成的光检测器，用于在由光源照射测量目标物之后接收光，并将光转换成电信号从而检测光的强度; 以及放大器，其包括用于以预定的放大系数对光学检测器的检测信号进行电流 - 电压转换的电流 - 电压转换电路。 在光学位移检测机构中，使用光谱半宽度为10nm以上的光源，由此可以以2mW以上的输出功率驱动光源，而不产生模式跳噪声和光反馈噪声。