公开(公告)号：US08857439B2

公开(公告)日：2014-10-14

申请号：US12831913

申请日：2010-07-07

申请人： Anant V. Hegde ,  Kasey Kai-Chi Li

发明人： Anant V. Hegde ,  Kasey Kai-Chi Li

IPC分类号： A61F5/56 ,  A61C5/14

CPC分类号： A61F5/566

摘要： A variably automated tissue retention system generally comprises an oral appliance retractably coupled to a covering which is secured to an anterior portion of the tongue. As the subject moves their tongue naturally or sleeps and the tongue becomes hypotonic, the subject's tongue may move posteriorly. As the covering pulls the tongue anteriorly or maintains a position of the tongue, the base of the tongue may be inhibited or prevented from collapsing posteriorly against the pharyngeal tissue walls and thereby allow the subject to breathe normally by automatically increasing the suction pressure on the tongue to maintain securement of the covering to the tongue as the tongue moves posteriorly.

摘要翻译： 可变地自动化的组织保持系统通常包括可伸缩地联接到覆盖物的口腔器具，其被固定到舌头的前部。 当主体自然地移动舌头或睡觉时，舌头变低，受试者的舌头可能向后移动。 当覆盖物将舌头向前拉或保持舌头的位置时，可以抑制或防止舌头的基部向后折叠到咽组织壁，从而允许受试者通过自动增加舌头上的吸入压力而正常呼吸 当舌头向后移动时，保持覆盖物到舌头的固定。

公开(公告)号：US20110180076A1

公开(公告)日：2011-07-28

申请号：US13045396

申请日：2011-03-10

申请人： Anant V. Hegde ,  Kasey Kai-Chi LI

发明人： Anant V. Hegde ,  Kasey Kai-Chi LI

IPC分类号： A61F5/56

CPC分类号： A61F5/566

摘要： A wearable tissue retention system generally comprises an oral appliance retractably coupled to a covering which is secured to an anterior portion of the tongue. As the subject moves their tongue naturally or sleeps and the tongue becomes hypotonic, the subject's tongue may move posteriorly. As the covering pulls the tongue anteriorly or maintains a position of the tongue, the base of the tongue may be inhibited or prevented from collapsing posteriorly against the pharyngeal tissue walls and thereby allow the subject to breathe normally by automatically increasing the suction pressure on the tongue to maintain securement of the covering to the tongue as the tongue moves posteriorly. The pump and electronics may be comfortably worn directly by the subject to prevent any tubing or wire entanglement.

摘要翻译： 可穿戴组织保持系统通常包括可伸缩地联接到固定到舌头的前部的覆盖物的口腔器具。 当主体自然地移动舌头或睡觉时，舌头变低，受试者的舌头可能向后移动。 当覆盖物将舌头向前拉或保持舌头的位置时，可以抑制或防止舌头的基部向后折叠到咽组织壁，从而允许受试者通过自动增加舌头上的吸入压力而正常呼吸 当舌头向后移动时，保持覆盖物到舌头的固定。 泵和电子设备可以被物体直接舒适地磨损，以防止任何管道或电线缠结。

公开(公告)号：US20110240037A1

公开(公告)日：2011-10-06

申请号：US13160469

申请日：2011-06-14

申请人： Anant V. Hegde ,  Kasey Kai-Chi Li ,  Phil Houle ,  Casidy Hallsten ,  Chris D. Owen

发明人： Anant V. Hegde ,  Kasey Kai-Chi Li ,  Phil Houle ,  Casidy Hallsten ,  Chris D. Owen

IPC分类号： A61F5/56

CPC分类号： A61F2/00 ,  A61B17/320016 ,  A61B17/3209 ,  A61B2017/248 ,  A61F5/56

摘要： Methods and tools are disclosed for inserting an implant device that treats snoring and apnea of a patient by altering the position of a soft palate. Methods and tools can make an incision in patient's soft and hard palate to create a cavity that can house the implant. The tools can have visually observable markings that can be aligned with the incision, thus controlling the depth of the cavity. A needle having an incision edge can be used to make an incision in patient's soft palate. The needle can be bent into a suitable longitudinal shape to allow easier access and visualization of the process. A blade that makes the cavity in the tissue can be housed inside a channel in the needle. The tools may have stoppers to prevent excessive extension and retraction of the blade thus preventing an excessive cavity depth. Some tools may also house the implant device, which may be implanted after the cavity is formed.

摘要翻译： 公开了用于插入通过改变软腭的位置来治疗患者的打鼾和呼吸暂停的植入装置的方法和工具。 方法和工具可以在病人的柔软和硬腭中形成切口，以创建可容纳植入物的腔体。 工具可以具有可与切口对准的视觉上可观察到的标记，从而控制腔的深度。 具有切口边缘的针可用于在患者的软腭中进行切口。 针可以弯曲成适当的纵向形状，以允许更容易地进入和可视化过程。 使得组织中的空腔可以容纳在针的通道内的刀片。 工具可以具有止动件以防止叶片的过度的伸展和缩回，从而防止过大的腔深度。 一些工具还可以容纳植入装置，其可以在腔形成之后植入。

公开(公告)号：US07882842B2

公开(公告)日：2011-02-08

申请号：US11355927

申请日：2006-02-15

申请人： Nikhil D. Bhat ,  Anant V. Hegde ,  George Yoseung Choi

发明人： Nikhil D. Bhat ,  Anant V. Hegde ,  George Yoseung Choi

IPC分类号： A61B19/00

CPC分类号： A61F5/566 ,  A61B5/0031 ,  A61B5/1076 ,  A61B5/4818 ,  A61C7/00 ,  A61F2/00 ,  A61F5/56 ,  A61N1/0519 ,  A61N1/0546 ,  A61N1/0548 ,  A61N1/3601

摘要： An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods of using the device are also disclosed. The airway implant device comprises a deformable element to control the opening of an air passageway. Preferably the deformable element is an electroactive polymer element. Energizing of the electroactive polymer element provides support for the walls of an air passageway, when the walls collapse, and thus, completely or partially opens the air passageway. Some embodiments of the invention include a sensor capable of sensing the possible occurrence of an apneic event and activating the deformable element of the airway implant device. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.

摘要翻译： 公开了一种用于在空气通道中保持和/或形成开口的气道植入装置。 还公开了使用该装置的方法。 气道植入装置包括可变形元件以控制空气通道的开口。 优选地，可变形元件是电活性聚合物元件。 电活性聚合物元件的通电为空气通道的壁提供支撑，当壁崩溃时，从而完全或部分地打开空气通道。 本发明的一些实施例包括能够感测呼吸暂停事件的可能发生并激活气道植入装置的可变形元件的传感器。 本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。

公开(公告)号：US20090173352A1

公开(公告)日：2009-07-09

申请号：US12261968

申请日：2008-10-30

申请人： Nikhil D. Bhat ,  Anant V. Hegde ,  Kasey Li ,  Matthew Goebel ,  HongPeng Wang ,  Ryan Woo

发明人： Nikhil D. Bhat ,  Anant V. Hegde ,  Kasey Li ,  Matthew Goebel ,  HongPeng Wang ,  Ryan Woo

IPC分类号： A61F5/56

CPC分类号： A61F5/566

摘要： The present invention provides an airway implant device having an electroactive polymer element, including: a composite layer having a polymer substrate and a biocompatible conductive material, wherein the composite layer also can be opposing surfaces; and a conductive polymer layer disposed on at least one of the opposing surfaces of the composite layer, wherein the implant device is adapted and configured to modulate an opening of an air passageway. Some embodiments include a housing designed to conform to the shape of the palate. Some embodiments include an attachment element to secure the device to tissue. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.

摘要翻译： 本发明提供一种具有电活性聚合物元件的气道植入装置，包括：具有聚合物基底和生物相容的导电材料的复合层，其中复合层也可以是相对的表面; 以及设置在所述复合层的至少一个相对表面上的导电聚合物层，其中所述植入装置适于和构造成调制空气通道的开口。 一些实施例包括设计成符合腭形状的外壳。 一些实施例包括用于将装置固定到组织的附接元件。 本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。

公开(公告)号：US20090165803A1

公开(公告)日：2009-07-02

申请号：US12261978

申请日：2008-10-30

申请人： NIKHIL D. BHAT ,  Anant V. Hegde ,  Kasey Li ,  Matthew Goebel ,  HongPeng Wang

发明人： NIKHIL D. BHAT ,  Anant V. Hegde ,  Kasey Li ,  Matthew Goebel ,  HongPeng Wang

IPC分类号： A61F5/56

CPC分类号： A61F5/566

摘要： The present invention provides an implant for stabilizing the tongue, including: a first anchoring portion for securing a first end of the implant with the mandibula; a control portion connected with the anchoring portion, configured for selectively activating the implant; a flexible portion connected at its proximal end with the control portion, the flexible portion having three-dimensional flexibility in a non-energized state and the flexible portion having a lesser three-dimensional flexibility in a energized state, the flexible portion being selectively switchable between the non-energized and energized states by the control portion, wherein the flexible portion can be an electroactive polymer element having: a composite layer having a polymer substrate and a biocompatible conductive material, wherein the composite layer also can be opposing surfaces; and a conductive polymer layer disposed on at least one of the opposing surfaces of the composite layer; and a second anchoring portion connected with the flexible portion, the second anchoring portion being configured for connecting the implant with the base of the tongue. Some embodiments include a housing designed to conform to the shape of the palate. Some embodiments include an attachment element to secure the device to tissue. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.

摘要翻译： 本发明提供了一种用于稳定舌头的植入物，包括：第一锚固部分，用于固定植入物的第一端与下颌骨; 与所述锚定部分连接的控制部分，被配置为选择性地启动所述植入物; 其柔性部分在其近端处与控制部分连接，柔性部分具有处于非通电状态的三维柔性，并且柔性部分在通电状态下具有较小的三维柔性，柔性部分可选择性地在 所述柔性部分可以是电活性聚合物元件，所述电活性聚合物元件具有：具有聚合物基底和生物相容的导电材料的复合层，其中所述复合层也可以是相对的表面; 以及设置在复合层的至少一个相对表面上的导电聚合物层; 以及与所述柔性部分连接的第二锚固部分，所述第二锚固部分构造成用于将所述植入物与所述舌头的基部连接。 一些实施例包括设计成符合腭形状的外壳。 一些实施例包括用于将装置固定到组织的附接元件。 本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。

公开(公告)号：US20090259093A1

公开(公告)日：2009-10-15

申请号：US12420744

申请日：2009-04-08

申请人： Nikhil D. Bhat ,  Anant V. Hegde ,  George Yoseung Choi ,  Wally S. Buch

发明人： Nikhil D. Bhat ,  Anant V. Hegde ,  George Yoseung Choi ,  Wally S. Buch

IPC分类号： A61F2/02

CPC分类号： A61F2/0036 ,  A61F2250/0002 ,  A61F2250/001

摘要： A biologically implantable artificial sphincter system and methods of using the same is disclosed. The artificial sphincter system disclosed herein comprises a sphincter band and a piezoelectric element, both of which are adapted and configured for coordinated operation to open and/or close a body cavity. The artificial sphincter systems are useful in the treatment of urinary incontinence, fecal incontinence, and reflux disorders. The implanted artificial sphincter can also provide a signal to the recipient to urinate or defecate.

摘要翻译： 公开了一种生物可植入人造括约肌系统及其使用方法。 本文公开的人造括约肌系统包括括约肌带和压电元件，两者都适于和构造成用于协调操作以打开和/或关闭体腔。 人造括约肌系统可用于治疗尿失禁，大便失禁和反流疾病。 植入的人造括约肌还可以向接受者提供小便或排便的信号。

公开(公告)号：US07836888B2

公开(公告)日：2010-11-23

申请号：US10946435

申请日：2004-09-21

申请人： Anant V. Hegde ,  George Y. Choi ,  Wally S. Buch

发明人： Anant V. Hegde ,  George Y. Choi ,  Wally S. Buch

IPC分类号： A61F5/56

CPC分类号： A61L31/125 ,  A61B2017/248 ,  A61C7/00 ,  A61F2/00 ,  A61F5/56 ,  A61F5/566 ,  A61F2210/0023 ,  A61L31/14 ,  A61N1/0517 ,  A61N1/0519 ,  A61N1/0548 ,  A61N1/3601 ,  Y10S602/902

摘要： A system and device for maintaining and/or creating patency in airways is disclosed. The methods of using the system and device are also disclosed. The system includes a power source that energizes a electro-active polymer implant. The energized polymer implant provides stiffness and shape to the airway, thereby minimizing collapse or deformation of the airway. A method of making the device is also disclosed.

摘要翻译： 公开了一种用于在气道中维持和/或产生通畅的系统和装置。 还公开了使用该系统和装置的方法。 该系统包括为电活性聚合物植入物通电的电源。 通电的聚合物植入物为气道提供刚度和形状，从而最小化气道的塌陷或变形。 还公开了制造该器件的方法。

公开(公告)号：US20100004659A1

公开(公告)日：2010-01-07

申请号：US12168825

申请日：2008-07-07

申请人： Anant V. Hegde ,  Adrian McVicker ,  Jerry Sung Woo Choe ,  James B. Ross

发明人： Anant V. Hegde ,  Adrian McVicker ,  Jerry Sung Woo Choe ,  James B. Ross

IPC分类号： A61B17/58 ,  A61F5/56 ,  A61F13/20

CPC分类号： A61F5/566

摘要： Methods and tools that insert implants for the treatment of snoring and sleep apnea in a cavity created in the patient's tissue are disclosed. Some tools and methods can additionally verify that the cavity has proper cavitation depth and does not have unwanted perforations. The tools include: a sheath having a substantially flat portion for housing an implant, the sheath having a distal end and a proximal end, the sheath having a hollow collar on the proximal end, an insertion depth mark near the distal end, and a slit on the distal end, the slit being in fluid communication with the hollow collar; a substantially rigid pusher configured to be disposed within and in slidable engagement with the sheath, the pusher having a distal end and a proximal end, the pusher having a rigid body having an outside diameter for slidably engaging with the hollow collar of the sheath, a tip on the distal end for engaging a proximal end of an implant, and a lumen extending from said proximal side to said distal side of said rigid body, the lumen configured for fluid communication with a syringe at the proximal end and in fluid communication with the sheath at the distal end.

摘要翻译： 公开了在患者组织中产生的腔中插入用于治疗打鼾和睡眠呼吸暂停的植入物的方法和工具。 一些工具和方法可以另外验证空腔具有适当的空化深度并且不具有不需要的穿孔。 所述工具包括：护套，其具有用于容纳植入物的基本上平坦的部分，所述护套具有远端和近端，护套在近端具有中空的环，在远端附近具有插入深度标记， 在所述远端处，所述狭缝与所述中空轴环流体连通; 一个基本上刚性的推动器，其构造成设置在护套内并与护套滑动接合，该推动器具有远端和近端，该推动器具有刚体，该刚体具有用于与护套的空心环滑动接合的外径， 在远端上的尖端用于接合植入物的近端，以及从所述刚体的所述近侧延伸到所述远端侧的内腔，所述内腔构造成用于在近端处与注射器流体连通并且与所述近端流体连通 护套在远端。

公开(公告)号：US06893437B2

公开(公告)日：2005-05-17

申请号：US10241183

申请日：2002-09-10

申请人： David K. Swanson ,  Huy D. Phan ,  Anant V. Hegde

发明人： David K. Swanson ,  Huy D. Phan ,  Anant V. Hegde

IPC分类号： A61B18/14 ,  A61B18/16

CPC分类号： A61B18/1492 ,  A61B2018/00065 ,  A61B2018/00214 ,  A61B2018/00238 ,  A61B2018/1472

摘要： An electrode assembly adapted to transmit electrical energy for ablating body tissue includes an expandable and collapsible non-compliant body made of a durable material and defining an interior adapted to receive a medium containing ions. The body includes a porous region, an electrode adapted to transmit electrical energy located in the interior of the body, a microporous membrane located on the porous region of the non-compliant body, and the microporous membrane is sized to pass ions contained in the medium without substantial medium perfusion therethrough, to thereby enable ionic transport of electrical energy from the ion-containing medium to the exterior of the electrode assembly to ablate body tissue.

摘要翻译： 适于传递用于烧蚀身体组织的电能的电极组件包括由耐用材料制成并且限定适于接收含有离子的介质的内部的可膨胀和可折叠的非柔顺体。 主体包括多孔区域，适于透射位于身体内部的电能的电极，位于非顺应性体的多孔区域上的微多孔膜，并且微多孔膜的尺寸设定为使包含在介质中的离子 无需通过其进行实质的介质灌注，从而使电能从电离离子的介质到电极组件的外部离子转运以烧蚀身体组织。