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    Method for Diagnosing, Prognosing and Treating Glioma
    29.
    发明申请
    Method for Diagnosing, Prognosing and Treating Glioma 审中-公开
    诊断，预后和治疗胶质瘤的方法

    公开(公告)号：US20070141066A1

    公开(公告)日：2007-06-21

    申请号：US11609071

    申请日：2006-12-11

    申请人： Heidi Phillips ,  William Forrest ,  Samir Kharbanda ,  Thomas Wu

    发明人： Heidi Phillips ,  William Forrest ,  Samir Kharbanda ,  Thomas Wu

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  G06F19/00 ,  A61K39/395 ,  A61K33/24

    CPC分类号： C12Q1/6886 ,  A61K45/06 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2500/00

    摘要： The invention provides generally a method of monitoring, diagnosing, prognosing and treating glioma. Specifically, the invention provides for three (3) prognostic subclasses of glioma, which are differentially associated with activation of the akt and notch signaling pathways. Tumor displaying neural or proneural PN lineage markers (including notch pathway elements) show longer median patient survival, while the two remaining tumor markers Prolif and Mes are associated with shortened survival. Tumors classified in this manner may also be treated with the appropriate PN- Prolif- or Mes-therapeutic corresponding to the subclassification in combination with anti-mitotic agents, anti-angiogenic agents, Akt antagonists, and neural differentiation agents. Alternatively, the invention also provides for method of prognosing and diagnosing glioma with a two-gene model based on the expression levels of PTEN and DLL3.

    摘要翻译： 本发明提供一种监测，诊断，预后和治疗胶质瘤的方法。 具体而言，本发明提供了三（3）个胶质瘤的预后亚类，其与akt和缺口信号传导途径的激活差异相关。 显示神经或倾向性PN谱系标志物（包括切口通路元件）的肿瘤显示较长的患者中位数，而剩余的两个肿瘤标志物Prolif和Mes与生存期缩短相关。 以这种方式分类的肿瘤也可以用与抗有丝分裂剂，抗血管生成剂，Akt拮抗剂和神经分化剂组合的对应于分类的适当的PN- Prolif-或Mes-治疗来治疗。 或者，本发明还提供了基于PTEN和DLL3的表达水平用双基因模型预测和诊断胶质瘤的方法。