公开(公告)号：US10948415B2

公开(公告)日：2021-03-16

申请号：US16529463

申请日：2019-08-01

Applicant: LI-COR, Inc.

Inventor： Han-Wei Wang

IPC: G01N21/64 ,  G06F3/0484 ,  G06F3/0485 ,  G06F3/0488 ,  H04N5/225 ,  G06T7/55 ,  G02B21/16 ,  G02B30/50 ,  G06F3/0354 ,  G01N21/17

Abstract: Methods for determining surgical margins using an imaging device are described that use multiple cameras to image a biological sample on a turntable bathed in white light or fluorescing due to a systemically administered dye. Fluorescence farther away from an excitation light source can be compensated upon determining a 3-D position of portions of the sample. The turntable is turned and tilted in order to take enough images to prepare an animation of the sample. In a graphical user interface, the animation can be stopped, zoomed, and tilted per a user's gesture, touch, tablet-tilting, or other commands. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.

公开(公告)号：US10379048B2

公开(公告)日：2019-08-13

申请号：US15192771

申请日：2016-06-24

Applicant: LI-COR, Inc.

Inventor： Han-Wei Wang

IPC: G01N21/64 ,  G06F3/0484 ,  G06F3/0485 ,  G06F3/0488 ,  H04N5/225 ,  G06T7/55 ,  G02B21/16 ,  G02B27/22 ,  G06F3/0354 ,  G01N21/17

Abstract: An imaging device is described that uses multiple cameras to image a biological sample on a turntable bathed in white light or fluorescing due to a systemically administered dye. Fluorescence farther away from an excitation light source can be compensated upon determining a 3-D position of portions of the sample. The turntable is turned and tilted in order to take enough images to prepare an animation of the sample. In a graphical user interface, the animation can be stopped, zoomed, and tilted per a user's gesture, touch, tablet-tilting, or other commands. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.

公开(公告)号：US20170309063A1

公开(公告)日：2017-10-26

申请号：US15494088

申请日：2017-04-21

Applicant: LI-COR, Inc.

Inventor： Han-Wei Wang

IPC: G06T15/20 ,  G01N23/22 ,  G01N23/223 ,  G06F3/0354 ,  G06T19/00 ,  G06F3/0488 ,  G06F3/0484 ,  B43K8/02 ,  G06T19/20

CPC classification number: G06T15/20 ,  B43K8/02 ,  G01N21/1702 ,  G01N21/31 ,  G01N21/4795 ,  G01N21/6456 ,  G01N23/046 ,  G01N23/2204 ,  G01N23/223 ,  G01N29/0672 ,  G01N29/225 ,  G01N29/2418 ,  G01N2223/401 ,  G01N2223/408 ,  G06F3/03545 ,  G06F3/04842 ,  G06F3/04845 ,  G06F3/04886 ,  G06T19/003 ,  G06T19/20 ,  G06T2219/2016

Abstract: Methods and devices are disclosed for the imaging of a biological sample from all rotational perspectives in three-dimensional space and with multiple imaging modalities. A biological sample is positioned on an imaging stage that is capable of full 360-degree rotation in at least one of two orthogonal axes. Positioned about the stage are imaging modules enabling the recording of a series of images in multiple modalities, including reflected visible light, fluorescence, X-ray, ultrasound, and optical coherence tomography. A computer can use the images to construct three-dimensional models of the sample and to render images of the sample conveying information from one or more imaging channels. The rendered images can be displayed for an operator who can manipulate the images to present additional information or viewing angles of the sample. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.