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公开(公告)号：US20210181110A1
公开(公告)日：2021-06-17
申请号：US17177583
申请日：2021-02-17
Applicant: LI-COR, Inc.
Inventor： Han-Wei Wang
IPC: G01N21/64 , G06F3/0484 , G06F3/0485 , G06F3/0488 , H04N5/225 , G06T7/55 , G02B21/16 , G02B30/50
Abstract: Methods for determining surgical margins using an imaging device are described that use multiple cameras to image a biological sample on a turntable bathed in white light or fluorescing due to a systemically administered dye. Fluorescence farther away from an excitation light source can be compensated upon determining a 3-D position of portions of the sample. The turntable is turned and tilted in order to take enough images to prepare an animation of the sample. In a graphical user interface, the animation can be stopped, zoomed, and tilted per a user's gesture, touch, tablet-tilting, or other commands. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.
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公开(公告)号：US10775309B2
公开(公告)日：2020-09-15
申请号：US16456511
申请日：2019-06-28
Applicant: LI-COR, Inc.
Inventor： Han-Wei Wang , Lyle R. Middendorf
Abstract: Methods and devices are disclosed for the imaging of a biological sample with a top-down camera and a side-view camera. A biological sample is held on an imaging stage that is capable of rotation in two orthogonal axes. The top-down and side-view cameras can record a series of images of the sample using multiple imaging modalities at different rotational positions of the imaging stage. The top-down camera can be translated along its optical axis to affect the camera zoom and influence the resolution and field of view of the recorded images. Fluorescence excitation light sources can be positioned proximate to each of the top-down and side-view cameras to provide substantially uniform illumination of the sample for imaging with each camera.
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公开(公告)号：US10386301B2
公开(公告)日：2019-08-20
申请号：US15955567
申请日：2018-04-17
Applicant: LI-COR, Inc.
Inventor： Han-Wei Wang , Lyle R. Middendorf
Abstract: Methods and devices are disclosed for the imaging of a biological sample with a top-down camera and a side-view camera. A biological sample is held on an imaging stage that is capable of rotation in two orthogonal axes. The top-down and side-view cameras can record a series of images of the sample using multiple imaging modalities at different rotational positions of the imaging stage. The top-down camera can be translated along its optical axis to affect the camera zoom and influence the resolution and field of view of the recorded images. Fluorescence excitation light sources can be positioned proximate to each of the top-down and side-view cameras to provide substantially uniform illumination of the sample for imaging with each camera.
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公开(公告)号：US20180140197A1
公开(公告)日：2018-05-24
申请号：US15819603
申请日：2017-11-21
Applicant: LI-COR, Inc.
Inventor： Han-Wei Wang , Lyle R. Middendorf
CPC classification number: A61B5/0077 , A61B6/481 , A61B6/50 , G06T1/0007 , H04N5/23216 , H04N5/23245 , H04N5/23254 , H04N5/23267 , H04N5/2354
Abstract: Methods and systems are provided for the detecting and presenting of faint signals from a real-time interactive imager. A real-time view of a subject is controlled by a user by entering commands that move the subject or a camera used to record the real-time view. The rate of this movement is monitored, and when the rate descends below a preset value, a trigger is sent to the camera. In response to the trigger, the camera switches to a lower frame frequency for capturing the real-time view of the subject, thereby increasing the amount of light collected in each frame, and increasing the sensitivity of the camera to faint signals. The methods and systems are particularly relevant for surgical or biopsy imaging, in which both a higher frame rate preview image of a subject for 3D visualization, and a higher sensitivity fluorescence image of the subject for tumor margin assessment, are desired.
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5.发明申请公开(公告)号：US20210259553A1
公开(公告)日：2021-08-26
申请号：US17237430
申请日：2021-04-22
Applicant: LI-COR, Inc.
Inventor： Han-Wei Wang
Abstract: Machine-readable media and computer systems are provided for the highlighting of features in composite images through the alternating of images having complementary colors. An image having a feature of interest is used to generate one or more pseudo color images. A series of a pseudo color images and one or more additional pseudo color or original color images are then alternately displayed so that the differently colored regions among the series of images are easily recognizable to an operator. The differently colored regions differ in having hues that are complementary to one another. The methods are particularly useful for the display of information using two or more imaging modalities and channels, such as is the case for some medical applications in which a natural-light image of pink or light-red tissue with deeper red or blue vasculature is overlaid with another functional image. In these cases, a feature present in the functional image can be more easily perceived when displayed in a composite overlay with an underlying image from another imaging modality or channel.
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Patent Agency Ranking
公开(公告)号：US11051696B2
公开(公告)日：2021-07-06
申请号：US16359852
申请日：2019-03-20
Applicant: LI-COR, Inc.
Inventor： Han-Wei Wang
Abstract: Methods are provided for the highlighting of features in composite images through the alternating of images having complementary colors. An image having a feature of interest is used to generate one or more pseudo color images. A series of a pseudo color images and one or more additional pseudo color or original color images are then alternately displayed so that the differently colored regions among the series of images are easily recognizable to an operator. The differently colored regions differ in having hues that are complementary to one another. The methods are particularly useful for the display of information using two or more imaging modalities and channels, such as is the case for some medical applications in which a natural-light image of pink or light-red tissue with deeper red or blue vasculature is overlaid with another functional image. In these cases, a feature present in the functional image can be more easily perceived when displayed in a composite overlay with an underlying image from another imaging modality or channel.
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公开(公告)号：US20160377545A1
公开(公告)日：2016-12-29
申请号：US15192771
申请日：2016-06-24
Applicant: LI-COR, Inc.
Inventor： Han-Wei Wang
IPC: G01N21/64 , G06F3/0354 , G06F3/0488 , G06T7/00
CPC classification number: G01N21/6456 , G01N21/6458 , G01N21/6486 , G01N2021/1776 , G02B21/16 , G02B27/2271 , G06F3/03545 , G06F3/04845 , G06F3/04847 , G06F3/0485 , G06F3/04886 , G06T7/55 , G06T2207/10064 , G06T2207/30096 , G06T2207/30204 , H04N5/2251 , H04N5/2256
Abstract: An imaging device is described that uses multiple cameras to image a biological sample on a turntable bathed in white light or fluorescing due to a systemically administered dye. Fluorescence farther away from an excitation light source can be compensated upon determining a 3-D position of portions of the sample. The turntable is turned and tilted in order to take enough images to prepare an animation of the sample. In a graphical user interface, the animation can be stopped, zoomed, and tilted per a user's gesture, touch, tablet-tilting, or other commands. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.
Abstract translation: 描述了一种成像装置，其使用多个相机来将生物样品成像在由白色光沐浴的转台上或由于全身施用的染料而发荧光。 在确定样品部分的3-D位置时，可以补偿远离激发光源的荧光。 转盘转动并倾斜，以便拍摄足够的图像来准备样品的动画。 在图形用户界面中，可以根据用户的手势，触摸，平板电脑倾斜或其他命令来停止，缩放和倾斜动画。 图像处理可以是使用可消毒或一次性触摸笔输入的触摸手势。
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公开(公告)号：US20160245753A1
公开(公告)日：2016-08-25
申请号：US15049970
申请日：2016-02-22
Applicant: LI-COR, Inc.
Inventor： Han-Wei Wang
CPC classification number: G01N21/6458 , G01N21/6428 , G01N21/6456 , G01N2021/1787 , G01N2021/6439 , G01N2201/06113 , G01N2201/12 , G02B21/367 , G06T7/0012 , G06T7/55 , G06T11/60 , G06T15/205 , G06T17/20 , G06T2207/10024 , G06T2207/10048 , G06T2207/10056 , G06T2207/10064 , G06T2207/30024 , G06T2207/30096 , G06T2207/30196 , H04N5/2256 , H04N5/332 , H04N7/181
Abstract: Biopsy imaging devices with an imaging stage configured to rotate and tilt a biological sample, as well as a method for using it, are described. The stage can use rotating bearings or extendible, telescoping arms. The device has a white light for taking normal pictures and a near-infrared laser light for causing a fluorescence-biomolecule probed sample to fluoresce for fluorescence images in a light-tight housing. A set of both types of pictures are taken from angles around, above, and below the biopsy sample with one or more cameras to generate a 3-D model in a computer of the biopsy with fluorescence markings. The 3-D model can then be rendered and viewed on a display by a surgeon to determine if sufficient margins were removed from the patient.
Abstract translation: 描述了具有被配置为旋转和倾斜生物样品的成像台的活组织检查成像装置，以及其使用方法。 舞台可以使用旋转轴承或可伸缩的伸缩臂。 该装置具有用于拍摄正常图像的白光和近红外激光，用于使荧光 - 生物分子探测的样品在无光外壳中的荧光图像发荧光。 使用一个或多个相机从活检样本周围，上方和下方的角度拍摄一组两种类型的图像，以在具有荧光标记的活检的计算机中产生3-D模型。 然后可以由外科医生在显示器上呈现和观看3-D模型，以确定是否从患者中移除了足够的边缘。
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公开(公告)号：US10993622B2
公开(公告)日：2021-05-04
申请号：US15819603
申请日：2017-11-21
Applicant: LI-COR, Inc.
Inventor： Han-Wei Wang , Lyle R. Middendorf
Abstract: Methods and systems are provided for the detecting and presenting of faint signals from a real-time interactive imager. A real-time view of a subject is controlled by a user by entering commands that move the subject or a camera used to record the real-time view. The rate of this movement is monitored, and when the rate descends below a preset value, a trigger is sent to the camera. In response to the trigger, the camera switches to a lower frame frequency for capturing the real-time view of the subject, thereby increasing the amount of light collected in each frame, and increasing the sensitivity of the camera to faint signals. The methods and systems are particularly relevant for surgical or biopsy imaging, in which both a higher frame rate preview image of a subject for 3D visualization, and a higher sensitivity fluorescence image of the subject for tumor margin assessment, are desired.
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公开(公告)号：US20190323966A1
公开(公告)日：2019-10-24
申请号：US16456511
申请日：2019-06-28
Applicant: LI-COR, Inc.
Inventor： Han-Wei Wang , Lyle R. Middendorf
Abstract: Methods and devices are disclosed for the imaging of a biological sample with a top-down camera and a side-view camera. A biological sample is held on an imaging stage that is capable of rotation in two orthogonal axes. The top-down and side-view cameras can record a series of images of the sample using multiple imaging modalities at different rotational positions of the imaging stage. The top-down camera can be translated along its optical axis to affect the camera zoom and influence the resolution and field of view of the recorded images. Fluorescence excitation light sources can be positioned proximate to each of the top-down and side-view cameras to provide substantially uniform illumination of the sample for imaging with each camera.
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