Method of Determining Surgical Margins Using Fluorescence Biopsy Specimen Imager

    公开(公告)号:US20210181110A1

    公开(公告)日:2021-06-17

    申请号:US17177583

    申请日:2021-02-17

    Applicant: LI-COR, Inc.

    Inventor: Han-Wei Wang

    Abstract: Methods for determining surgical margins using an imaging device are described that use multiple cameras to image a biological sample on a turntable bathed in white light or fluorescing due to a systemically administered dye. Fluorescence farther away from an excitation light source can be compensated upon determining a 3-D position of portions of the sample. The turntable is turned and tilted in order to take enough images to prepare an animation of the sample. In a graphical user interface, the animation can be stopped, zoomed, and tilted per a user's gesture, touch, tablet-tilting, or other commands. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.

    Top-down and rotational side view biopsy specimen imager and methods

    公开(公告)号:US10775309B2

    公开(公告)日:2020-09-15

    申请号:US16456511

    申请日:2019-06-28

    Applicant: LI-COR, Inc.

    Abstract: Methods and devices are disclosed for the imaging of a biological sample with a top-down camera and a side-view camera. A biological sample is held on an imaging stage that is capable of rotation in two orthogonal axes. The top-down and side-view cameras can record a series of images of the sample using multiple imaging modalities at different rotational positions of the imaging stage. The top-down camera can be translated along its optical axis to affect the camera zoom and influence the resolution and field of view of the recorded images. Fluorescence excitation light sources can be positioned proximate to each of the top-down and side-view cameras to provide substantially uniform illumination of the sample for imaging with each camera.

    Top-down and rotational side view biopsy specimen imager and methods

    公开(公告)号:US10386301B2

    公开(公告)日:2019-08-20

    申请号:US15955567

    申请日:2018-04-17

    Applicant: LI-COR, Inc.

    Abstract: Methods and devices are disclosed for the imaging of a biological sample with a top-down camera and a side-view camera. A biological sample is held on an imaging stage that is capable of rotation in two orthogonal axes. The top-down and side-view cameras can record a series of images of the sample using multiple imaging modalities at different rotational positions of the imaging stage. The top-down camera can be translated along its optical axis to affect the camera zoom and influence the resolution and field of view of the recorded images. Fluorescence excitation light sources can be positioned proximate to each of the top-down and side-view cameras to provide substantially uniform illumination of the sample for imaging with each camera.

    Motion-Adaptive Interactive Imaging Method
    4.
    发明申请

    公开(公告)号:US20180140197A1

    公开(公告)日:2018-05-24

    申请号:US15819603

    申请日:2017-11-21

    Applicant: LI-COR, Inc.

    Abstract: Methods and systems are provided for the detecting and presenting of faint signals from a real-time interactive imager. A real-time view of a subject is controlled by a user by entering commands that move the subject or a camera used to record the real-time view. The rate of this movement is monitored, and when the rate descends below a preset value, a trigger is sent to the camera. In response to the trigger, the camera switches to a lower frame frequency for capturing the real-time view of the subject, thereby increasing the amount of light collected in each frame, and increasing the sensitivity of the camera to faint signals. The methods and systems are particularly relevant for surgical or biopsy imaging, in which both a higher frame rate preview image of a subject for 3D visualization, and a higher sensitivity fluorescence image of the subject for tumor margin assessment, are desired.

    COMPUTER SYSTEMS AND MEDIA FOR COMPLEMENTARY COLOR FLASHING FOR MULTICHANNEL IMAGE PRESENTATION

    公开(公告)号:US20210259553A1

    公开(公告)日:2021-08-26

    申请号:US17237430

    申请日:2021-04-22

    Applicant: LI-COR, Inc.

    Inventor: Han-Wei Wang

    Abstract: Machine-readable media and computer systems are provided for the highlighting of features in composite images through the alternating of images having complementary colors. An image having a feature of interest is used to generate one or more pseudo color images. A series of a pseudo color images and one or more additional pseudo color or original color images are then alternately displayed so that the differently colored regions among the series of images are easily recognizable to an operator. The differently colored regions differ in having hues that are complementary to one another. The methods are particularly useful for the display of information using two or more imaging modalities and channels, such as is the case for some medical applications in which a natural-light image of pink or light-red tissue with deeper red or blue vasculature is overlaid with another functional image. In these cases, a feature present in the functional image can be more easily perceived when displayed in a composite overlay with an underlying image from another imaging modality or channel.

    Complementary color flashing for multichannel image presentation

    公开(公告)号:US11051696B2

    公开(公告)日:2021-07-06

    申请号:US16359852

    申请日:2019-03-20

    Applicant: LI-COR, Inc.

    Inventor: Han-Wei Wang

    Abstract: Methods are provided for the highlighting of features in composite images through the alternating of images having complementary colors. An image having a feature of interest is used to generate one or more pseudo color images. A series of a pseudo color images and one or more additional pseudo color or original color images are then alternately displayed so that the differently colored regions among the series of images are easily recognizable to an operator. The differently colored regions differ in having hues that are complementary to one another. The methods are particularly useful for the display of information using two or more imaging modalities and channels, such as is the case for some medical applications in which a natural-light image of pink or light-red tissue with deeper red or blue vasculature is overlaid with another functional image. In these cases, a feature present in the functional image can be more easily perceived when displayed in a composite overlay with an underlying image from another imaging modality or channel.

    FLUORESCENCE BIOPSY SPECIMEN IMAGER AND METHODS
    7.
    发明申请
    FLUORESCENCE BIOPSY SPECIMEN IMAGER AND METHODS 审中-公开
    荧光生物样本图像和方法

    公开(公告)号:US20160377545A1

    公开(公告)日:2016-12-29

    申请号:US15192771

    申请日:2016-06-24

    Applicant: LI-COR, Inc.

    Inventor: Han-Wei Wang

    Abstract: An imaging device is described that uses multiple cameras to image a biological sample on a turntable bathed in white light or fluorescing due to a systemically administered dye. Fluorescence farther away from an excitation light source can be compensated upon determining a 3-D position of portions of the sample. The turntable is turned and tilted in order to take enough images to prepare an animation of the sample. In a graphical user interface, the animation can be stopped, zoomed, and tilted per a user's gesture, touch, tablet-tilting, or other commands. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.

    Abstract translation: 描述了一种成像装置,其使用多个相机来将生物样品成像在由白色光沐浴的转台上或由于全身施用的染料而发荧光。 在确定样品部分的3-D位置时,可以补偿远离激发光源的荧光。 转盘转动并倾斜,以便拍摄足够的图像来准备样品的动画。 在图形用户界面中,可以根据用户的手势,触摸,平板电脑倾斜或其他命令来停止,缩放和倾斜动画。 图像处理可以是使用可消毒或一次性触摸笔输入的触摸手势。

    Motion-adaptive interactive imaging method

    公开(公告)号:US10993622B2

    公开(公告)日:2021-05-04

    申请号:US15819603

    申请日:2017-11-21

    Applicant: LI-COR, Inc.

    Abstract: Methods and systems are provided for the detecting and presenting of faint signals from a real-time interactive imager. A real-time view of a subject is controlled by a user by entering commands that move the subject or a camera used to record the real-time view. The rate of this movement is monitored, and when the rate descends below a preset value, a trigger is sent to the camera. In response to the trigger, the camera switches to a lower frame frequency for capturing the real-time view of the subject, thereby increasing the amount of light collected in each frame, and increasing the sensitivity of the camera to faint signals. The methods and systems are particularly relevant for surgical or biopsy imaging, in which both a higher frame rate preview image of a subject for 3D visualization, and a higher sensitivity fluorescence image of the subject for tumor margin assessment, are desired.

    Top-Down and Rotational Side View Biopsy Specimen Imager and Methods

    公开(公告)号:US20190323966A1

    公开(公告)日:2019-10-24

    申请号:US16456511

    申请日:2019-06-28

    Applicant: LI-COR, Inc.

    Abstract: Methods and devices are disclosed for the imaging of a biological sample with a top-down camera and a side-view camera. A biological sample is held on an imaging stage that is capable of rotation in two orthogonal axes. The top-down and side-view cameras can record a series of images of the sample using multiple imaging modalities at different rotational positions of the imaging stage. The top-down camera can be translated along its optical axis to affect the camera zoom and influence the resolution and field of view of the recorded images. Fluorescence excitation light sources can be positioned proximate to each of the top-down and side-view cameras to provide substantially uniform illumination of the sample for imaging with each camera.

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