-
21.发明申请公开(公告)号：US20190300878A1
公开(公告)日：2019-10-03
申请号：US16284393
申请日：2019-02-25
Applicant: Larry J. Smith
Inventor： Larry J. Smith
IPC: C12N15/113 , C12N15/11 , C07H21/04
Abstract: Compositions and methods for down modulating expression of target nucleic acids using a single strand oligoribonucleotide siRNA compound are disclosed.
-
公开(公告)号：US08488210B2
公开(公告)日：2013-07-16
申请号：US11765345
申请日：2007-06-19
Applicant: Larry J. Smith
Inventor： Larry J. Smith
IPC: H04N1/04
CPC classification number: G06K7/10722 , G06K7/10831 , H04N1/0464 , H04N2201/0432 , H04N2201/0446
Abstract: Disclosed are embodiments of methods, systems, and apparatus for providing multiple image fields or regions on an imaging array. In certain preferred embodiments, a high density imaging array may be partitioned into two or more regions, each of which may be used to render a separate view of the scan volume. This arrangement may provide an increase in the effective scan volume beyond the volume available with a single imager having a single point of view and may allow for reading of encoded symbols at a variety of orientations that would otherwise preclude accurate imaging with a single imager.
Abstract translation: 公开了用于在成像阵列上提供多个图像场或区域的方法，系统和装置的实施例。 在某些优选实施例中，高密度成像阵列可以被划分成两个或更多个区域，每个区域可用于呈现扫描体积的单独视图。 这种布置可以提高有效扫描体积超过具有单个视点的单个成像器可用的体积，并且可以允许以各种取向读取编码的符号，否则将使用单个成像器排除精确的成像。
-
公开(公告)号：US08181876B2
公开(公告)日：2012-05-22
申请号：US12127685
申请日：2008-05-27
Applicant: Larry J. Smith
Inventor： Larry J. Smith
CPC classification number: G06K7/14 , G06K7/1491
Abstract: A method aligns a second image of an object taken at a second time with a first image taken at a first time, wherein the object experiences motion relative to an imager between the first and second times. The images are formed of sets of pixels arranged horizontally and vertically in a pattern. The method operates on the pixels of the second image by performing a series of operations to affect an affine transformation without performing matrix arithmetic, preferably by table look-up. The method shifts the pixels of the second image vertically by a constant vertical offset, shifts the pixels of the second image horizontally by a constant horizontal offset, shears the second image horizontally by a skew factor, shears the second image vertically by a skew factor, scales the second image horizontally by a horizontal scale factor; and scale the second image vertically by a vertical scale factor.
Abstract translation: 一种方法将在第二时间拍摄的对象的第二图像与在第一次拍摄的第一图像对准，其中所述对象在第一次和第二次之间经历相对于成像器的运动。 图像由图案中水平和垂直布置的像素组形成。 该方法通过执行一系列操作来对第二图像的像素进行操作，以优化地通过表查找来影响仿射变换而不执行矩阵运算。 该方法将第二图像的像素垂直移位恒定的垂直偏移，将第二图像的像素水平移动恒定的水平偏移，将第二图像水平地剪切偏斜因子，将第二图像垂直剪切偏斜因子， 水平缩放第二幅图像水平比例因子; 并垂直缩放第二个图像垂直比例因子。
-
公开(公告)号：US20080167263A1
公开(公告)日：2008-07-10
申请号：US11963242
申请日：2007-12-21
Applicant: Dayton T. Reardan , Larry J. Smith , Robert E. Klem
Inventor： Dayton T. Reardan , Larry J. Smith , Robert E. Klem
CPC classification number: C07K16/1063 , A61K31/136 , A61K31/70 , A61K31/7088 , A61K31/713 , A61K39/39558 , A61K39/39575 , A61K2039/505 , C07K16/32 , C07K2317/34 , C12N9/0002 , A61K2300/00
Abstract: Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens associated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders. Also provided are methods for modulating the efficacy of nucleic acid based therapeutics.
Abstract translation: 本文公开了共价反应性抗原类似物。 本发明的抗原可用于刺激对与特定医学病症相关的预定抗原特异性的催化抗体的产生。 抗原类似物也可用于永久灭活在某些自身免疫性疾病以及某些淋巴组织增生性疾病中产生的内源性产生的催化抗体。 还提供了用于调节基于核酸的治疗剂的功效的方法。
-
25.发明授权
公开(公告)号：US5683987A
公开(公告)日：1997-11-04
申请号：US487141
申请日：1995-06-07
Applicant: Larry J. Smith
Inventor： Larry J. Smith
IPC: C12N15/09 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K48/00 , C12N15/11 , C12N15/113 , C12N15/115 , A01N43/04 , C07H19/04 , C07H21/02 , C07H71/04
CPC classification number: C12N15/115 , C12N15/111 , C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/18 , C12N2310/315 , C12N2310/322 , C12N2320/31 , C12N2320/32
Abstract: The present invention provides novel compositions and methods useful in cancer therapy for inhibiting the multidrug resistance phenotype, which often thwarts long-term chemotherapeutic regimens. The novel compositions of matter comprise oligonucleotides targeted to the human MDR1 and MRP genes, which inhibit expression of these genes, thereby rendering tumors and other forms of cancer more susceptible to the cytotoxic effects of chemotherapeutic agents. Oligonucleotides are also provided that inhibit the multidrug resistance phenotype by exerting an aptameric effect.
Abstract translation: 本发明提供了用于癌症治疗中用于抑制多药耐药性表型的新型组合物和方法，其经常阻碍长期化疗方案。 物质的新型组合物包含靶向人MDR1和MRP基因的寡核苷酸，其抑制这些基因的表达，从而使肿瘤和其它形式的癌症对化学治疗剂的细胞毒性作用更敏感。 还提供寡核苷酸，其通过施加适体效应来抑制多药耐药性表型。
-
Patent Agency Ranking
公开(公告)号：US4648060A
公开(公告)日：1987-03-03
申请号：US635949
申请日：1984-07-30
Applicant: Curtis M. Allen , Larry J. Smith
Inventor： Curtis M. Allen , Larry J. Smith
CPC classification number: H03B21/02
Abstract: A signal synthesizer system allowing a wide variety of signal sources for test and evaluation is provided. In one embodiment, the signal synthesizer system is a phase calibration system resulting in a wideband, variable phase two channel synthesized source with good phase accuracy over its entire frequency range.
Abstract translation: 提供信号合成器系统，允许用于测试和评估的各种信号源。 在一个实施例中，信号合成器系统是相位校准系统，其在整个频率范围内产生具有良好相位精度的宽带可变相位二通道合成源。
-
公开(公告)号：US4630217A
公开(公告)日：1986-12-16
申请号：US635312
申请日：1984-07-26
Applicant: Larry J. Smith , William M. Spaulding, Sr.
Inventor： Larry J. Smith , William M. Spaulding, Sr.
CPC classification number: H03B21/02
Abstract: A signal synthesizer system allowing a wide variety of signal sources for test and evaluation is provided. In one embodiment, the signal synthesizer system is a precision two channel synthesizer having a variety of capabilities which are made possible by having two independently controlled sources with a common controller residing in one instrument.
Abstract translation: 提供信号合成器系统，允许用于测试和评估的各种信号源。 在一个实施例中，信号合成器系统是具有各种能力的精密双通道合成器，其通过具有驻留在一个仪器中的公共控制器的两个独立控制的源来实现。
-
公开(公告)号：US11359201B2
公开(公告)日：2022-06-14
申请号：US16552478
申请日：2019-08-27
Applicant: Larry J. Smith
Inventor： Larry J. Smith
IPC: C12N15/113 , A61K31/713 , A61K31/7125 , A61K31/712
Abstract: Compositions and methods for down modulating target gene expression are disclosed.
-
公开(公告)号：US10392619B2
公开(公告)日：2019-08-27
申请号：US15010837
申请日：2016-01-29
Applicant: Larry J. Smith
Inventor： Larry J. Smith
IPC: A61K31/712 , A61K31/7125 , C12N15/113 , A61K31/713
Abstract: Compositions and method for down modulating target gene expression which RNA interference, as well as methods for administering said compositions are disclosed. The method comprises administering a first oligonucleotide strand to a cell, incubating the cells for a time period suitable for uptake of the first oligo nucleotide strand prior to administration of a second oligonucleotide strand, wherein the first strand and the second strand form an intracellular duplex which is effective to catalyze degradation of gene target mRNA or inhibit translation of said mRNA.
-
30.发明申请METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION USING COMPONENTS THAT SELF ASSEMBLE IN CELLS AND PRODUCE RNAI ACTIVITY 审中-公开使用自身在细胞中组装并产生RNAI活性的组分调节基因表达的方法和组合物公开(公告)号：US20160272972A1
公开(公告)日：2016-09-22
申请号：US15093711
申请日：2016-04-07
Applicant: Larry J. Smith
Inventor： Larry J. Smith
IPC: C12N15/113 , A61K31/7105
CPC classification number: C12N15/113 , A61K31/7105 , C12N15/111 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2310/141 , C12N2310/322 , C12N2310/50 , C12N2320/30 , C12N2320/51 , C12N2320/52
Abstract: Compositions and methods for downmodulating expression of target nucleic acids are disclosed.
Abstract translation: 公开了用于下调靶核酸表达的组合物和方法。
-
-
-
-
-
-
-
-
-
Search Results
35
records
(took 0.038 seconds)
