公开(公告)号：US4814485A

公开(公告)日：1989-03-21

申请号：US936777

申请日：1986-12-02

申请人： Marcel Descamps ,  Dino Nisato ,  Walter Verstraeten

发明人： Marcel Descamps ,  Dino Nisato ,  Walter Verstraeten

IPC分类号： C07C67/00 ,  C07C229/28 ,  C07C229/34 ,  C07C231/00 ,  C07C231/12 ,  C07C233/47 ,  C07C233/81 ,  C07C239/00 ,  C07C271/22 ,  C07C301/00 ,  C07C303/40 ,  C07C311/19 ,  C07K1/113 ,  C07K5/06 ,  C07K14/81 ,  C07C101/02

CPC分类号： C07C271/22 ,  Y02P20/55

摘要： The invention relates to new (4S)-4-aminobutanoic acid derivatives of general formula: ##STR1## in which: R represents an N-protective group,R.sub.1 represents hydrogen, an alkali metal atom such as lithium, sodium or potassium or a liabile group,R.sub.2 represents a group of formula: ##STR2## in which W represents hydrogen, a hydroxy group or an alkyl radical containing from 1 to 4 carbon atoms or an alkoxy radical containing from 1 to 4 carbon atoms, and to a process for the preparation of the said derivatives.The 4-aminobutanoic acid derivatives according to the invention are useful as synthesis intermediates for the preparation of peptides derived from statin analogues.

摘要翻译： 本发明涉及以下通式的新的（4S）-4-氨基丁酸衍生物：其中：R表示N-保护基，R 1表示氢，碱金属原子如锂，钠或钾或Liabile 基团，R 2表示下式的基团：其中W表示氢，羟基或含有1至4个碳原子的烷基或含有1至4个碳原子的烷氧基的式：＆lt; IMAGE＆gt; 所述衍生物的制备。 根据本发明的4-氨基丁酸衍生物可用作制备衍生自他汀类似物的肽的合成中间体。

公开(公告)号：US4661514A

公开(公告)日：1987-04-28

申请号：US807733

申请日：1985-12-11

申请人： Marcel Descamps ,  Yves Berger

发明人： Marcel Descamps ,  Yves Berger

IPC分类号： A61K31/34 ,  A61K31/343 ,  A61P9/08 ,  A61P9/10 ,  C07D307/80

CPC分类号： C07D307/80 ,  Y10S514/821

摘要： Pharmaceutical and veterinary compositions having as essential active ingredient at least one benzofuran derivative of the general formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof in which R represents an amino, monoethylamino or diethylamino radical and X.sub.1 and X.sub.2 represent hydrogen or iodine with the proviso that when R represents diethylamino X.sub.1 and X.sub.2 are different.These compositions are useful for the treatment of ischemic cardiac disorders.

公开(公告)号：US4575513A

公开(公告)日：1986-03-11

申请号：US628210

申请日：1984-07-05

申请人： Marcel Descamps ,  Yves Berger

发明人： Marcel Descamps ,  Yves Berger

IPC分类号： A61K31/34 ,  A61K31/343 ,  A61P9/08 ,  A61P9/10 ,  C07D307/80

CPC分类号： C07D307/80 ,  Y10S514/821

摘要： Pharmaceutical and veterinary compositions having as essential active ingredient at least one benzofuran derivative of the general formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof in which R represents an amino, monoethylamino or diethylamino radical and X.sub.1 and X.sub.2 represent hydrogen or iodine with the proviso that when R represents diethylamino X.sub.1 and X.sub.2 are different.These compositions are useful for the treatment of ischemic cardiac disorders.

公开(公告)号：US4012394A

公开(公告)日：1977-03-15

申请号：US601919

申请日：1975-08-04

申请人： Marcel Descamps ,  Henri Inion

发明人： Marcel Descamps ,  Henri Inion

IPC分类号： C07D401/06

CPC分类号： C07D401/06

摘要： 3-Indolyl pyridyl ketones of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein R.sub.1 representsA straight- or branched-chain saturated or unsaturated alkyl group having not more than 6 carbon atoms, a benzyl group optionally substituted in the aromatic portion by a chlorine atom or a methoxy groupOr ##STR2## wherein A represents an alkylene chain of from 2 to 6 carbon atoms and R.sub.4 and R.sub.5, which may be the same or different, are each an alkyl group having from 1 to 5 carbon atoms, or R.sub.4 and R.sub.5 are joined together to form with the nitrogen atom a piperidino, pyrrolidino or morpholino group,R.sub.2 representsA branched-or straight-chain alkyl group having from 1 to 4 carbon atoms, a phenyl group optionally substituted by a fluorine, chlorine, or bromine atom or a methoxy or cyclohexyl group; andR.sub.3 representsA 2-pyridyl, 3-pyridyl or 4-pyridyl group.They are effective as fibrinolytic and anti-inflammatory agents.

摘要翻译： 具有以下通式的3-吲哚基吡啶酮：其中R1代表具有不超过6个碳原子的直链或支链链饱和或不饱和的烷基，其中R 1表示在其中可选择的苄基 其中A表示2至6个碳原子的亚烷基链，R 4和R 5可以相同或不同，各自为具有1至5个碳原子的烷基 碳原子或R4和R5连接在一起，与氮原子一起形成哌啶子基，吡咯烷子基或吗啉基，R2代表具有1至4个碳原子的分支链或直链烷基，由A选择性取代的苯基 氟，氯或溴甲烷或甲氧基或环烯基; 且R3代表2-吡啶基，3-吡啶基或4-吡啶基。