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21.发明申请AZABICYCLIC CARBAMATES AND THEIR USE AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS 有权异丁烯酸碳酸酯及其作为ALPHA-7 NICOTINIC乙酰胆碱受体激动剂公开(公告)号：US20100324085A1
公开(公告)日：2010-12-23
申请号：US12871495
申请日：2010-08-30
申请人： Timo Flessner , Frank-Gerhard Böss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Maria-Van Kampen , Franz-Josef Van der Staay
发明人： Timo Flessner , Frank-Gerhard Böss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Dieter Lang , Joachim Luithle , Maria-Van Kampen , Franz-Josef Van der Staay
IPC分类号： A61K31/4375 , C07D453/02 , A61P25/00
CPC分类号： C07D453/02
摘要： The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.
摘要翻译： 本发明涉及新的苯并噻吩 - ，苯并呋喃和吲哚脲，以及其用于制备用于治疗和/或预防疾病和改善感知，集中，学习和/或记忆的药物的用途。
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22.发明授权Aza-bicyclic N-biarylamides with affinity for the α7 nicotinic acetylcholine receptor 有权对α7烟碱乙酰胆碱受体具有亲和力的氮杂 - 双环N-二芳基酰胺公开(公告)号：US07138410B2
公开(公告)日：2006-11-21
申请号：US10508108
申请日：2003-03-03
申请人： Joachim Luithle , Frank-Gerhard Böss , Christina Erb , Katrin Schnizler , Timo Flessner , Marja van Kampen , Christoph Methfessel , Frank-Thorsten Hafner
发明人： Joachim Luithle , Frank-Gerhard Böss , Christina Erb , Katrin Schnizler , Timo Flessner , Marja van Kampen , Christoph Methfessel , Frank-Thorsten Hafner
IPC分类号： A61K31/439 , A61K31/5377 , C07D453/02 , C07D413/12
CPC分类号： C07D453/02
摘要： The invention relates to novel 1-aza-bicyclic N-biarylamides, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.
摘要翻译： 本发明涉及新的1-氮杂 - 双环N-二芳基酰胺，其生产和使用方法，用于生产用于治疗和/或预防疾病以及改善感知，浓度，学习能力和记忆力的药物。
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公开(公告)号：US20060160877A1
公开(公告)日：2006-07-20
申请号：US10516777
申请日：2003-06-02
申请人： Joachim Luithle , Frank-Gerhard Boss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Timo Flessner , Marja Kampen , Franz-Josef Staay
发明人： Joachim Luithle , Frank-Gerhard Boss , Christina Erb , Frank-Thorsten Hafner , Katrin Schnizler , Timo Flessner , Marja Kampen , Franz-Josef Staay
IPC分类号： C07D487/04 , A01N43/38
CPC分类号： C07D453/02
摘要： The invention relates to novel 2-heteroaryl carboxamides and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的2-杂芳基羧酰胺及其用于制备用于治疗和/或预防疾病和改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US07354930B2
公开(公告)日：2008-04-08
申请号：US10565181
申请日：2004-07-19
申请人： Timo Fleβner , Frank-Gerhard Böβ , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
发明人： Timo Fleβner , Frank-Gerhard Böβ , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
IPC分类号： A01N43/90 , A61K31/44 , C07D453/02
CPC分类号： A61K31/439 , A61K45/06 , C07D453/02
摘要： The invention relates to N-biarylamides useful for the prophylaxis and/or treatment of impairments of perception, concentration, learning and/or memory, and to processes for preparing them, and pharmaceutical compositions containing them.
摘要翻译： 本发明涉及用于预防和/或治疗感知，浓度，学习和/或记忆障碍的N-二芳基酰胺及其制备方法以及含有它们的药物组合物。
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公开(公告)号：US08030329B2
公开(公告)日：2011-10-04
申请号：US12099108
申请日：2008-04-07
申请人： Timo Flessner , Frank-Gerhard Böss , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
发明人： Timo Flessner , Frank-Gerhard Böss , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
CPC分类号： A61K31/439 , A61K45/06 , C07D453/02
摘要： The invention relates to N-biarylamides useful for the prophylaxis and/or treatment of impairments of perception, concentration, learning and/or memory, and to processes for preparing them, and pharmaceutical compositions containing them.
摘要翻译： 本发明涉及可用于预防和/或治疗感知，浓度，学习和/或记忆障碍的N-二芳基酰胺及其制备方法，以及含有它们的药物组合物。
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公开(公告)号：US20070112023A1
公开(公告)日：2007-05-17
申请号：US10565181
申请日：2004-07-19
申请人： Timo Flessner , Frank-Gerhard Boss , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
发明人： Timo Flessner , Frank-Gerhard Boss , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
IPC分类号： A61K31/4745 , C07D453/02
CPC分类号： A61K31/439 , A61K45/06 , C07D453/02
摘要： The invention relates to N-biarylamides, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improvement in cognition, concentration power, learning power and/or memory.
摘要翻译： 本发明涉及N-二芳基酰胺，其生产和使用方法，用于生产用于治疗和/或预防疾病和改善认知，集中力，学习能力和/或记忆力的药物。
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公开(公告)号：US20080214602A1
公开(公告)日：2008-09-04
申请号：US12099108
申请日：2008-04-07
申请人： Timo Flessner , Frank-Gerhard Boss , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
发明人： Timo Flessner , Frank-Gerhard Boss , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
IPC分类号： A61K31/439 , A61P25/00 , A61P29/00
CPC分类号： A61K31/439 , A61K45/06 , C07D453/02
摘要： The invention relates to N-biarylamides useful for the prophylaxis and/or treatment of impairments of perception, concentration, learning and/or memory, and to processes for preparing them, and pharmaceutical compositions containing them.
摘要翻译： 本发明涉及可用于预防和/或治疗感知，浓度，学习和/或记忆障碍的N-二芳基酰胺及其制备方法，以及含有它们的药物组合物。
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公开(公告)号：US08691840B2
公开(公告)日：2014-04-08
申请号：US13235743
申请日：2011-09-19
申请人： Timo Flessner , Frank-Gerhard Böss , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
发明人： Timo Flessner , Frank-Gerhard Böss , Frank-Thorsten Hafner , Joachim Luithle , Christoph Methfessel , Leila Telan
CPC分类号： A61K31/439 , A61K45/06 , C07D453/02
摘要： The invention relates to N-biarylamides useful for the prophylaxis and/or treatment of impairments of perception, concentration, learning and/or memory, and to processes for preparing them, and pharmaceutical compositions containing them.
摘要翻译： 本发明涉及可用于预防和/或治疗感知，浓度，学习和/或记忆障碍的N-二芳基酰胺及其制备方法，以及含有它们的药物组合物。
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29.发明申请BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM 审中-公开用于治疗中枢神经系统癌症的苯唑呋喃和苯并噻吩衍生物公开(公告)号：US20100125073A1
公开(公告)日：2010-05-20
申请号：US12439062
申请日：2007-08-28
申请人： Olaf Weber , Verena Voehringer , Hans-Georg Lerchen , Frank-Thorsten Hafner , Joerg Keldenich , Karl-Heinz Schlemmer , Ursula Krenz , Bernd Riedl
发明人： Olaf Weber , Verena Voehringer , Hans-Georg Lerchen , Frank-Thorsten Hafner , Joerg Keldenich , Karl-Heinz Schlemmer , Ursula Krenz , Bernd Riedl
IPC分类号： A61K31/5377 , C07D307/82 , A61K31/343 , C07D413/10 , A61K31/422 , A61K31/427 , C07D417/10 , C07D405/10 , A61K31/443 , C07D413/12 , A61P35/00
CPC分类号： A61K31/343 , C07D307/82
摘要： The present invention relates to benzofuran and benzothiophene derivatives and compositions containing such compounds for the production of medicaments for the treatment of cancers of the central nervous system as monotherapy or combination with other agents.
摘要翻译： 本发明涉及苯并呋喃和苯并噻吩衍生物和含有这些化合物的组合物，用于制备用于治疗中枢神经系统癌症的药物作为单一疗法或与其它药剂组合。
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![7H-dibenzo[b,g][1,5]dioxocin-5-one derivatives and use thereof](/abs-image/US/2006/11/02/US20060247303A1/abs.jpg.150x150.jpg)
30.发明申请7H-dibenzo[b,g][1,5]dioxocin-5-one derivatives and use thereof 审中-公开7H-二苯并[b，g] [1,5]二氧杂环己烯-5-酮衍生物及其用途公开(公告)号：US20060247303A1
公开(公告)日：2006-11-02
申请号：US10531881
申请日：2003-10-21
申请人： Hilmar Bischoff , Frank-Thorsten Hafner , Carsten Schmeck , Joachim Telser , Alexandros Vakalopoulos , Gabriele Wirtz , Marcus Bauser , David Bruckner , Martina Wuttke
发明人： Hilmar Bischoff , Frank-Thorsten Hafner , Carsten Schmeck , Joachim Telser , Alexandros Vakalopoulos , Gabriele Wirtz , Marcus Bauser , David Bruckner , Martina Wuttke
IPC分类号： A61K31/365 , C07D321/02
CPC分类号： A61K31/365 , C07D321/12
摘要： The present invention relates to substituted 7H-dibenzo[b,g][1,5]dioxocin-5-one-derivatives, to processes for their preparation and to their use in medicaments, in particular as inhibitors of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemia, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias and arteriosclerosis.
摘要翻译： 本发明涉及取代的7H-二苯并[b，g] [1,5]二氧环辛-5-酮衍生物，其制备方法及其在药物中的用途，特别是胆固醇酯转移蛋白的抑制剂 CETP）用于治疗和/或预防心血管疾病，特别是低脂蛋白血症，血脂异常，高甘油三酯血症，高脂血症和动脉硬化。
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