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公开(公告)号：US20080200725A1
公开(公告)日：2008-08-21
申请号：US11747203
申请日：2007-05-10
申请人： Joseph MacDougall
发明人： Joseph MacDougall
IPC分类号： C07C257/00
CPC分类号： C07C229/08 , C07C229/26 , C07C237/06 , C07C277/08 , C07C279/10 , C07C279/14
摘要： The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
摘要翻译： 本发明描述了由氨基酸分子和脂肪酸分子产生的化合物。 化合物为氨基酸或其衍生物与预先与亚硫酰卤反应的适当脂肪酸所形成的氨基 - 脂肪酸化合物形式的酸酐键或其混合物。 这种分子的施用提供补充氨基酸，其具有增强的生物利用度和特定脂肪酸赋予的额外益处。
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公开(公告)号：US20080200705A1
公开(公告)日：2008-08-21
申请号：US11856358
申请日：2007-09-17
IPC分类号： C07C229/26
CPC分类号： C07C279/22
摘要： The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty compounds bound by an amide linkage, or mixtures thereof produced by reacting creatine or derivatives thereof with an appropriate fatty acid in the presence of dichloromethane and a pyridine catalyst, previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
摘要翻译： 本发明描述了由肌酸分子和脂肪酸分子产生的化合物。 化合物是由酰胺键结合的肌酸 - 脂肪族化合物的形式，或其混合物，其通过使肌酸或其衍生物与适当的脂肪酸在二氯甲烷和吡啶催化剂存在下反应而生成，预先与亚硫酰卤反应。 这种分子的施用提供补充肌酸，具有增强的生物利用度和特定脂肪酸赋予的额外益处。
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公开(公告)号：US20090156812A1
公开(公告)日：2009-06-18
申请号：US11958747
申请日：2007-12-18
申请人： Joseph MacDougall , Shan Chaudhuri
发明人： Joseph MacDougall , Shan Chaudhuri
IPC分类号： C07D239/10
CPC分类号： C07D239/54 , Y02P20/55
摘要： The present invention describes compounds produced from an orotic acid molecule and an amino acid molecule. The compounds being in the form of amino acid orotate compounds bound by an amide linkage and produced by one of two disclosed methods; 1) reacting orotic acid or derivatives thereof with a thionyl halide, and then combining the acyl halide with an amino acid in the presence of dichloromethane and a DMAP catalyst; or 2) protecting the carboxylic acid of an amino acid and then combining the amino acid with a DCC activated orotic acid, followed by removal of the carboxylic acid protecting group. The resulting amino acid orotate amide has an enhanced stability in solution as compared to a related ester. In addition, specific benefits are conferred by the particular amino acid used to form the compounds in addition to, and separate from, the orotate substituent.
摘要翻译： 本发明描述了由乳清酸分子和氨基酸分子产生的化合物。 化合物是由酰胺键结合的氨基酸乳清酸酯化合物的形式，并通过两种公开的方法之一产生; 1）将乳清酸或其衍生物与亚硫酰卤反应，然后在二氯甲烷和DMAP催化剂的存在下将酰基卤与氨基酸组合; 或2）保护氨基酸的羧酸，然后将氨基酸与DCC活化的乳清酸结合，然后除去羧酸保护基。 所得到的氨基酸乳清酸酰胺与相关酯相比在溶液中具有增强的稳定性。 此外，特别的益处是由用于形成化合物的具体氨基酸，除了和与乳清酸酯取代基分开外，还有其独特之处。
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公开(公告)号：US20080200723A1
公开(公告)日：2008-08-21
申请号：US11856374
申请日：2007-09-17
IPC分类号： C07C229/30
CPC分类号： C07C279/10
摘要： The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting creatine or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
摘要翻译： 本发明描述了由肌酸分子和脂肪酸分子产生的化合物。 肌酸 - 脂肪酸化合物形式的化合物通过酸酐键结合，或其混合物由肌酸或其衍生物与预先与亚硫酰卤反应的合适的脂肪酸反应制得。 这种分子的施用提供补充肌酸，具有增强的生物利用度和特定脂肪酸赋予的额外益处。
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公开(公告)号：US07319157B1
公开(公告)日：2008-01-15
申请号：US11676630
申请日：2007-02-20
IPC分类号： C07C233/00
CPC分类号： C07C279/22
摘要： The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty compounds bound by an amide linkage, or mixtures thereof produced by reacting creatine or derivatives thereof with an appropriate fatty acid in the presence of dichloromethane and a pyridine catalyst, previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
摘要翻译： 本发明描述了由肌酸分子和脂肪酸分子生成的化合物。 化合物是由酰胺键结合的肌酸 - 脂肪族化合物的形式，或其混合物，其通过使肌酸或其衍生物与适当的脂肪酸在二氯甲烷和吡啶催化剂存在下反应而生成，预先与亚硫酰卤反应。 这种分子的施用提供补充肌酸，具有增强的生物利用度和特定脂肪酸赋予的额外益处。
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公开(公告)号：US07314945B1
公开(公告)日：2008-01-01
申请号：US11676623
申请日：2007-02-20
IPC分类号： C07C101/00
CPC分类号： C07C279/10
摘要： The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting creatine or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
摘要翻译： 本发明描述了由肌酸分子和脂肪酸分子产生的化合物。 肌酸 - 脂肪酸化合物形式的化合物通过酸酐键结合，或其混合物由肌酸或其衍生物与预先与亚硫酰卤反应的合适的脂肪酸反应制得。 这种分子的施用提供补充肌酸，具有增强的生物利用度和特定脂肪酸赋予的额外益处。
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公开(公告)号：US07714154B2
公开(公告)日：2010-05-11
申请号：US12099306
申请日：2008-04-08
申请人： Joseph MacDougall
发明人： Joseph MacDougall
IPC分类号： C07C231/00
CPC分类号： C07C279/14 , C07C229/08 , C07C229/26 , C07C237/06 , C07C277/08
摘要： The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
摘要翻译： 本发明描述了由氨基酸分子和脂肪酸分子产生的化合物。 化合物为氨基酸或其衍生物与预先与亚硫酰卤反应的适当脂肪酸所形成的氨基 - 脂肪酸化合物形式的酸酐键或其混合物。 这种分子的施用提供补充氨基酸，其具有增强的生物利用度和特定脂肪酸赋予的额外益处。
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公开(公告)号：US20080281113A1
公开(公告)日：2008-11-13
申请号：US12099306
申请日：2008-04-08
申请人： Joseph MacDougall
发明人： Joseph MacDougall
IPC分类号： C07C227/14 , C07C209/14
CPC分类号： C07C279/14 , C07C229/08 , C07C229/26 , C07C237/06 , C07C277/08
摘要： The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
摘要翻译： 本发明描述了由氨基酸分子和脂肪酸分子产生的化合物。 化合物为氨基酸或其衍生物与预先与亚硫酰卤反应的适当脂肪酸所形成的氨基 - 脂肪酸化合物形式的酸酐键或其混合物。 这种分子的施用提供补充氨基酸，其具有增强的生物利用度和特定脂肪酸赋予的额外益处。
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