公开(公告)号：US20240308953A1

公开(公告)日：2024-09-19

申请号：US18263637

申请日：2022-01-24

Applicant: CUBE BIOTECH GMBH

Inventor： Roland Fabis ,  Jan Kubicek ,  Maertens Barbara

IPC: C07C229/76 ,  C07C229/26 ,  C07C237/10 ,  G01N33/20

CPC classification number: C07C229/76 ,  C07C229/26 ,  C07C237/10 ,  G01N33/20

Abstract: Soluble chelator-compounds, methods for their production and their use for the modification and/or immobilization of target molecules.

公开(公告)号：US12065511B2

公开(公告)日：2024-08-20

申请号：US16818560

申请日：2020-03-13

Applicant: STEALTH BIOTHERAPEUTICS INC.

Inventor： D. Travis Wilson ,  Marc W. Andersen ,  Elizabeth Mead

IPC: C07K5/10 ,  A61K38/06 ,  A61K38/07 ,  C07C229/26 ,  C07D209/16 ,  C07K5/06 ,  C07K5/065 ,  C07K5/068 ,  C07K5/072 ,  C07K5/08 ,  C07K5/087 ,  C07K5/09 ,  C07K5/107 ,  C07K5/11 ,  G01N33/68

CPC classification number: C07K5/10 ,  A61K38/06 ,  A61K38/07 ,  C07C229/26 ,  C07D209/16 ,  C07K5/06 ,  C07K5/06078 ,  C07K5/06086 ,  C07K5/06095 ,  C07K5/08 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/0817 ,  C07K5/1016 ,  C07K5/1019 ,  G01N33/68

Abstract: The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. For example, the peptides may be administered to subjects in need of a mitochondrial-targeted antioxidant.

公开(公告)号：US20230357121A1

公开(公告)日：2023-11-09

申请号：US17922999

申请日：2021-05-04

Applicant: DOMPE' FARMACEUTICI SPA

Inventor： Andrea ARAMINI ,  Marcello ALLEGRETTI ,  Gianluca BIANCHINI ,  Samuele LILLINI ,  Mara TOMASSETTI

IPC: C07C59/84 ,  C07C229/26 ,  C07C229/28

CPC classification number: C07C59/84 ,  C07C229/26 ,  C07C229/28 ,  C07C2601/14 ,  C07B2200/13

Abstract: The present invention relates to a new co-crystal of Ketoprofen, Lysine and Gabapentin, to pharmaceutical compositions and to their use in the prevention, reduction or treatment of pain and/or inflammation.

公开(公告)号：US10015979B2

公开(公告)日：2018-07-10

申请号：US15446922

申请日：2017-03-01

Applicant: Retrotope, Inc.

Inventor： Mikhail Sergeevich Shchepinov

IPC: A23D9/00 ,  A23L33/12 ,  C07H19/16 ,  C07C255/30 ,  C07C229/26 ,  C07C279/14 ,  C07C57/03 ,  A23L33/10

CPC classification number: A23L33/12 ,  A23D9/00 ,  A23D9/007 ,  A23K10/12 ,  A23K50/80 ,  A23L33/10 ,  A23L33/105 ,  A23L33/13 ,  A23L33/135 ,  A23L33/175 ,  A23L33/18 ,  A23L33/20 ,  A23V2002/00 ,  A61K9/0019 ,  A61K31/201 ,  C07B2200/05 ,  C07C57/03 ,  C07C229/26 ,  C07C255/30 ,  C07C279/14 ,  C07H19/16 ,  A23V2200/302 ,  A23V2200/30 ,  A23V2250/1872 ,  A23V2250/063 ,  A23V2250/0606 ,  A23V2250/206

Abstract: A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is 2H and/or at least one C atom is 13C. The nutrient is thus protected from, inter alia, active oxygen species.

公开(公告)号：US20180118661A1

公开(公告)日：2018-05-03

申请号：US15565802

申请日：2016-04-11

Applicant: Resilio Therapeutics, LLC

Inventor： Francis Xavier Tavares ,  Michael Peter Vitek

IPC: C07C229/46 ,  A61P25/28 ,  A61P25/00 ,  A61P35/00 ,  A61K45/06 ,  C07C271/16 ,  A61K31/27 ,  C07D317/36 ,  A61K31/357 ,  C07F9/09 ,  A61K31/6615 ,  C07D211/90 ,  A61K31/4422 ,  A61K31/223 ,  C07C251/24 ,  C07C275/16 ,  C07C235/34 ,  C07F9/06 ,  A61K31/661 ,  C07D269/00 ,  A61K31/395 ,  C07D285/34 ,  A61K31/549 ,  C07C381/00 ,  C07D263/44 ,  A61K31/421

CPC classification number: C07C229/46 ,  A61K31/195 ,  A61K31/22 ,  A61K31/223 ,  A61K31/27 ,  A61K31/357 ,  A61K31/395 ,  A61K31/421 ,  A61K31/4422 ,  A61K31/549 ,  A61K31/661 ,  A61K31/6615 ,  A61K45/06 ,  A61P25/00 ,  A61P25/28 ,  A61P35/00 ,  C07C229/26 ,  C07C235/34 ,  C07C235/78 ,  C07C251/24 ,  C07C271/16 ,  C07C271/22 ,  C07C275/16 ,  C07C381/00 ,  C07C2602/08 ,  C07D211/86 ,  C07D211/90 ,  C07D263/44 ,  C07D269/00 ,  C07D285/34 ,  C07D317/36 ,  C07D317/40 ,  C07F9/06 ,  C07F9/09 ,  A61K2300/00

Abstract: Novel compounds of formula (II) are disclosed. Compounds of formula (II) comprise ornithine derivatives or compounds that may metabolize to ornithine. Also disclosed are methods for the treatment of neurodegenerative diseases such as Alzheimer's Disease using compounds of formula (II).

公开(公告)号：US20180071402A1

公开(公告)日：2018-03-15

申请号：US15654585

申请日：2017-07-19

Applicant: Innate Pharma ,  Paul Scherrer Institut

Inventor： Delphine Bregeon ,  Patrick Dennler ,  Christian Belmant ,  Eliane Fischer ,  Laurent Gauthier ,  Francois Romagné ,  Roger Schibli

IPC: G01N33/68 ,  C12N9/10 ,  C12P21/00 ,  C07K19/00 ,  C07K16/00 ,  C07F9/50 ,  C07D277/06 ,  C07D257/08 ,  C07D225/08 ,  C07C323/60 ,  C07C323/12 ,  C07C247/04 ,  C07C233/62 ,  C07C229/26 ,  C07C223/02 ,  C07C217/08

CPC classification number: A61K47/6803 ,  A61K47/60 ,  A61K47/68 ,  A61K47/6807 ,  A61K47/6813 ,  A61K47/6817 ,  A61K47/6865 ,  A61K47/6871 ,  C07C217/08 ,  C07C223/02 ,  C07C229/26 ,  C07C233/62 ,  C07C247/04 ,  C07C323/12 ,  C07C323/60 ,  C07D225/08 ,  C07D257/08 ,  C07D277/06 ,  C07F9/5022 ,  C07K16/00 ,  C07K19/00 ,  C07K2317/40 ,  C12N9/1044 ,  C12P21/005 ,  G01N33/6854

Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.

公开(公告)号：US09901642B2

公开(公告)日：2018-02-27

申请号：US14340395

申请日：2014-07-24

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Zhiwei Yang ,  Parul Angrish ,  Xavier de Mollerat du Jeu ,  Kristin Wiederholt ,  Tao Wu

IPC: C07C227/06 ,  C07D211/28 ,  C07D211/58 ,  C12N15/88 ,  A61K48/00 ,  C07C229/08 ,  C12N15/113 ,  A61K47/54 ,  A61K47/48

CPC classification number: A61K47/54 ,  A61K47/543 ,  A61K48/0008 ,  C07C227/06 ,  C07C229/08 ,  C07D211/28 ,  C07D211/58 ,  C12N15/1137 ,  C12N15/88 ,  C12N2310/11 ,  C12N2310/141 ,  C07C229/26

Abstract: There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by reacting a primary amine with an unsaturated compound. Transfection complexes made using the amine-containing transfection compounds in combination with additional compounds to encapsulate biologically active agents such as nucleic acids are also provided for herein. Methods of using the transfection complexes for the in vivo or in vitro delivery of biologically active agents are also described. The transfection complexes of the present invention are highly potent, thereby allowing effective modulation of a biological activity at relatively low doses compared to analogous transfection compounds known in the art.

公开(公告)号：US20170286451A1

公开(公告)日：2017-10-05

申请号：US15499176

申请日：2017-04-27

Applicant: John Henry Page

Inventor： John Henry Page

IPC: G06F17/30 ,  G06F3/0484 ,  G09G5/373 ,  G06F3/0482 ,  G06F3/0485 ,  G09G5/377

CPC classification number: G06F16/29 ,  C07B2200/07 ,  C07C55/10 ,  C07C57/03 ,  C07C59/68 ,  C07C69/60 ,  C07C69/63 ,  C07C69/732 ,  C07C69/84 ,  C07C215/10 ,  C07C219/08 ,  C07C229/22 ,  C07C229/24 ,  C07C229/26 ,  C07C233/38 ,  C07C235/06 ,  C07C235/12 ,  C07C279/14 ,  C07C309/08 ,  C07C309/12 ,  C07C309/14 ,  C07C313/04 ,  C07C323/25 ,  C07C323/41 ,  C07C323/43 ,  C07C327/06 ,  C07C2601/14 ,  C07D333/20 ,  C07D339/04 ,  G06F3/0482 ,  G06F3/04845 ,  G06F3/04847 ,  G06F3/0485 ,  G06F16/22 ,  G09G5/373 ,  G09G5/377

Abstract: Methods, apparatus and software allowing a plurality of users to exchange and display information in real time or near real time regarding the resources each of them is viewing. This information is mapped graphically through the positioning and appearance of tokens representing other users relative to the resources currently displayed to each user.

公开(公告)号：US20170165290A1

公开(公告)日：2017-06-15

申请号：US15340082

申请日：2016-11-01

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC: A61K31/7105 ,  A61K47/22 ,  C07D241/08 ,  A61K31/711

CPC classification number: A61K31/7105 ,  A61K31/711 ,  A61K47/22 ,  A61K2121/00 ,  C07C229/12 ,  C07C229/22 ,  C07C229/24 ,  C07C229/26 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C07C271/22 ,  C07C279/14 ,  C07C323/58 ,  C07D207/16 ,  C07D209/20 ,  C07D209/24 ,  C07D233/64 ,  C07D241/08 ,  C07D265/32 ,  C07D403/06 ,  C07D413/06 ,  C07D487/04 ,  C07D487/06 ,  C12N15/87 ,  C12N15/88 ,  C12Q1/025 ,  G01N33/15

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US20170152213A1

公开(公告)日：2017-06-01

申请号：US15264315

申请日：2016-09-13

Applicant: Massachusetts Institute of Technology

Inventor： Daniel Griffith Anderson ,  Kathryn Ann Whitehead ,  Joseph A. Dorkin ,  Arturo Jose Vegas ,  Yunlong Zhang ,  Robert S. Langer

IPC: C07C225/06 ,  C07D319/16 ,  C07D295/16 ,  C07D487/04 ,  C07D207/09 ,  C07D211/34

CPC classification number: A61K47/22 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/225 ,  A61K31/357 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61K31/4985 ,  A61K31/573 ,  A61K31/704 ,  A61K31/713 ,  A61K45/06 ,  A61K47/18 ,  A61K47/542 ,  A61K47/543 ,  A61K47/6925 ,  C07C225/06 ,  C07C229/12 ,  C07C229/14 ,  C07C229/24 ,  C07C229/26 ,  C07C229/28 ,  C07C229/34 ,  C07C2601/14 ,  C07D207/09 ,  C07D211/14 ,  C07D211/26 ,  C07D211/34 ,  C07D241/04 ,  C07D295/13 ,  C07D295/15 ,  C07D295/16 ,  C07D319/16 ,  C07D319/18 ,  C07D487/04 ,  C12N15/111 ,  C12N15/1137 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  A61K2300/00

Abstract: Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.