公开(公告)号：US20090069422A1

公开(公告)日：2009-03-12

申请号：US11853277

申请日：2007-09-11

Applicant: Michele Molino ,  Joseph MacDougall

Inventor： Michele Molino ,  Joseph MacDougall

IPC: A61K31/22 ,  A61P21/06

CPC classification number: A61K31/22 ,  A61K2300/00

Abstract: A nutritional supplement comprising at least a therapeutically effective amount of ethyl pyruvate and a therapeutically effective amount of at least one α-hydroxy branched-chain amino acid metabolite is provided by the present invention. The ingredients of the present nutritional supplement substantially simultaneously act to induce a anabolically-favorable state for muscle by substantially simultaneously maintaining blood and muscle physiological pH levels as well as increasing cellular concentrations of branched-chain amino acids. Both a composition and a method are provided by the present disclosure.

Abstract translation: 本发明提供了至少包含治疗有效量的丙酮酸乙酯和治疗有效量的至少一种α-羟基支链氨基酸代谢物的营养补充剂。 本发明的营养补充剂的成分通过基本上同时维持血液和肌肉生理pH水平以及增加支链氨基酸的细胞浓度而基本上同时作用于诱导肌肉的合成代谢状态。 本公开提供了组合物和方法。

公开(公告)号：US08236952B2

公开(公告)日：2012-08-07

申请号：US11958747

申请日：2007-12-18

Applicant: Joseph MacDougall ,  Shan Chaudhuri

Inventor： Joseph MacDougall ,  Shan Chaudhuri

IPC: C07D239/557

CPC classification number: C07D239/54 ,  Y02P20/55

Abstract: The present invention describes compounds produced from an orotic acid molecule and an amino acid molecule. The compounds being in the form of amino acid orotate compounds bound by an amide linkage and produced by one of two disclosed methods; 1) reacting orotic acid or derivatives thereof with a thionyl halide, and then combining the acyl halide with an amino acid in the presence of dichloromethane and a DMAP catalyst; or 2) protecting the carboxylic acid of an amino acid and then combining the amino acid with a DCC activated orotic acid, followed by removal of the carboxylic acid protecting group. The resulting amino acid orotate amide has an enhanced stability in solution as compared to a related ester. In addition, specific benefits are conferred by the particular amino acid used to form the compounds in addition to, and separate from, the orotate substituent.

Abstract translation: 本发明描述了由乳清酸分子和氨基酸分子产生的化合物。 化合物是由酰胺键结合的氨基酸乳清酸酯化合物的形式，并通过两种公开的方法之一产生; 1）将乳清酸或其衍生物与亚硫酰卤反应，然后在二氯甲烷和DMAP催化剂的存在下将酰基卤与氨基酸组合; 或2）保护氨基酸的羧酸，然后将氨基酸与DCC活化的乳清酸结合，然后除去羧酸保护基。 所得到的氨基酸乳清酸酰胺与相关酯相比在溶液中具有增强的稳定性。 此外，特别的益处是由用于形成化合物的具体氨基酸，除了和与乳清酸酯取代基分开外，还有其独特之处。

公开(公告)号：US07645794B2

公开(公告)日：2010-01-12

申请号：US11853277

申请日：2007-09-11

Applicant: Michele Molino ,  Joseph MacDougall

Inventor： Michele Molino ,  Joseph MacDougall

IPC: A61K31/225 ,  A61K31/20

CPC classification number: A61K31/22 ,  A61K2300/00

Abstract: A nutritional supplement comprising at least a therapeutically effective amount of ethyl pyruvate and a therapeutically effective amount of at least one α-hydroxy branched-chain amino acid metabolite is provided by the present invention. The ingredients of the present nutritional supplement substantially simultaneously act to induce a anabolically-favorable state for muscle by substantially simultaneously maintaining blood and muscle physiological pH levels as well as increasing cellular concentrations of branched-chain amino acids. Both a composition and a method are provided by the present disclosure.

Abstract translation: 本发明提供了至少包含治疗有效量的丙酮酸乙酯和治疗有效量的至少一种α-羟基支链氨基酸代谢物的营养补充剂。 本发明的营养补充剂的成分通过基本上同时维持血液和肌肉生理pH水平以及增加支链氨基酸的细胞浓度而基本上同时作用于诱导肌肉的合成代谢状态。 本公开提供了组合物和方法。

公开(公告)号：US20090156648A1

公开(公告)日：2009-06-18

申请号：US11954652

申请日：2007-12-12

Applicant: Michele Molino ,  Joseph MacDougall

Inventor： Michele Molino ,  Joseph MacDougall

IPC: A61K31/4412 ,  C07D211/90

CPC classification number: C07D213/67

Abstract: The present invention relates to stable salts of pyridoxine and α-hydroxyisocaproic acid (HICA) endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral administration. A method of preparation is also provided.

Abstract translation: 本发明涉及具有与其各自作用有关的增强的营养和/或治疗功效的吡哆醇和α-羟基异己酸（HICA）的稳定盐，以及含有特别适合于口服给药的盐的固体组合物。 还提供了一种制备方法。

公开(公告)号：US07511164B2

公开(公告)日：2009-03-31

申请号：US11856374

申请日：2007-09-17

Applicant: Shan Chaudhuri ,  Joseph MacDougall ,  Jason Peters ,  James Ramsbottom

Inventor： Shan Chaudhuri ,  Joseph MacDougall ,  Jason Peters ,  James Ramsbottom

IPC: C07C51/00

CPC classification number: C07C279/10

Abstract: The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting creatine or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.

Abstract translation: 本发明描述了由肌酸分子和脂肪酸分子产生的化合物。 肌酸 - 脂肪酸化合物形式的化合物通过酸酐键结合，或其混合物由肌酸或其衍生物与预先与亚硫酰卤反应的合适的脂肪酸反应制得。 这种分子的施用提供补充肌酸，具有增强的生物利用度和特定脂肪酸赋予的额外益处。

公开(公告)号：US07511162B2

公开(公告)日：2009-03-31

申请号：US11747203

申请日：2007-05-10

Applicant: Joseph MacDougall

Inventor： Joseph MacDougall

IPC: C07C101/00

CPC classification number: C07C229/08 ,  C07C229/26 ,  C07C237/06 ,  C07C277/08 ,  C07C279/10 ,  C07C279/14

Abstract: The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.

Abstract translation: 本发明描述了由氨基酸分子和脂肪酸分子产生的化合物。 化合物为氨基酸或其衍生物与预先与亚硫酰卤反应的适当脂肪酸所形成的氨基 - 脂肪酸化合物形式的酸酐键或其混合物。 这种分子的施用提供补充氨基酸，其具有增强的生物利用度和特定脂肪酸赋予的额外益处。

公开(公告)号：US20080200704A1

公开(公告)日：2008-08-21

申请号：US11855360

申请日：2007-09-14

Applicant: Shan Chaudhuri ,  Joseph MacDougall ,  Jason Peters ,  James Ramsbottom

Inventor： Shan Chaudhuri ,  Joseph MacDougall ,  Jason Peters ,  James Ramsbottom

IPC: C07C233/01

CPC classification number: C07C279/22 ,  C07C233/47 ,  C07C233/48

Abstract: The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an amide linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.

Abstract translation: 本发明描述了由氨基酸分子和脂肪酸分子产生的化合物。 氨基酸脂肪酸化合物形式的化合物通过氨基酸或其衍生物与预先与亚硫酰卤反应的合适的脂肪酸反应而由酰胺键或其混合物结合。 这种分子的施用提供补充氨基酸，其具有增强的生物利用度和特定脂肪酸赋予的额外益处。

公开(公告)号：US20090163573A1

公开(公告)日：2009-06-25

申请号：US11962948

申请日：2007-12-21

Applicant: Marvin A. Heuer ,  Ken Clement ,  Michele Molino ,  Joseph MacDougall

Inventor： Marvin A. Heuer ,  Ken Clement ,  Michele Molino ,  Joseph MacDougall

IPC: A61P21/00 ,  A61K31/385 ,  A61K31/195

CPC classification number: A61K31/198 ,  A61K31/195 ,  A61K31/385 ,  A61K2300/00

Abstract: A nutritional composition comprising at least an effective amount of geranylgeranylacetone or derivative of geranygeranylacetone and an effective amount of glutamine or derivative of glutamine, wherein the ingredients act substantially simultaneously to increase protein synthesis and inhibit protein degradation in skeletal muscle, via enhanced expression of heat shock proteins in cells, particularly heat shock protein 72. A method of same is also provided.

Abstract translation: 一种营养组合物，其包含至少有效量的香叶基香叶基丙酮或前列腺素基丙酮衍生物和有效量的谷氨酰胺或谷氨酰胺衍生物，其中所述成分基本上同时作用，通过增强的热休克表达来增加蛋白质合成和抑制骨骼肌中的蛋白质降解 细胞中的蛋白质，特别是热休克蛋白72.还提供了其方法。

公开(公告)号：US20090156676A1

公开(公告)日：2009-06-18

申请号：US11954644

申请日：2007-12-12

Applicant: Michele Molino ,  Joseph MacDougall

Inventor： Michele Molino ,  Joseph MacDougall

IPC: A61K31/195 ,  C07C229/04

CPC classification number: C07C229/08

Abstract: The present invention relates to stable salts of β-alanine and an organic acid endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral administration. A method of preparation is also provided.

Abstract translation: 本发明涉及β-丙氨酸的稳定盐和赋予其对各自作用的增强的营养和/或治疗功效的有机酸，以及含有特别适合于口服给药的盐的固体组合物。 还提供了一种制备方法。

公开(公告)号：US20090156647A1

公开(公告)日：2009-06-18

申请号：US11954635

申请日：2007-12-12

Applicant: Michele Molino ,  Joseph MacDougall

Inventor： Michele Molino ,  Joseph MacDougall

IPC: A61K31/44 ,  A61P3/00

CPC classification number: A61K31/44

Abstract: A nutritional supplement comprising at least a therapeutically effective amount of pyridoxine α-hydroxyisocaproate is provided by the present invention. The ingredients of the present nutritional supplement act substantially simultaneously to maintain physiological blood and muscular pH and increase the time to muscular fatigue in a mammal during periods of repetitive forceful muscular exercise. A method of use is provided by the present disclosure.

Abstract translation: 包含至少治疗有效量的吡哆醇α-羟基异己酸的营养补充剂由本发明提供。 本发明的营养补充剂的成分基本上同时起作用以维持生理性血液和肌肉酸碱度，并且在重复强力肌肉运动期间增加哺乳动物肌肉疲劳的时间。 本公开提供了一种使用方法。