公开(公告)号：US20050209287A1

公开(公告)日：2005-09-22

申请号：US11076960

申请日：2005-03-11

Applicant: Matthew Olson ,  Martin Di Grandi

Inventor： Matthew Olson ,  Martin Di Grandi

IPC: A61K31/4196 ,  A61K31/4439 ,  C07D249/12 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D49/02

CPC classification number: C07D409/04 ,  C07D249/12 ,  C07D401/04 ,  C07D405/04

Abstract: The present invention is directed to compounds of formula (I): wherein R1, R2 and R3 are independently selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl and X1 and X2 are independently a bond or an linker group of 1 to 6 atoms and may be optional substituted or oxidized, or a prodrug, a pharmaceutically acceptable salt or a pharmaceutically active metabolite thereof. The invention is also directed to methods of using the same for treating HIV infections, or AIDs or preventing viral replication.

Abstract translation: 本发明涉及式（I）的化合物：其中R 1，R 2和R 3 3独立地选自 的烷基，烯基，炔基，环烷基，芳基和杂芳基，X 1和X 2独立地是1至6个原子的键或连接基团，并且可以是任选取代的 或氧化的，或其前药，药学上可接受的盐或其药物活性代谢物。 本发明还涉及使用该方法治疗HIV感染或AID或预防病毒复制的方法。

公开(公告)号：US20050203156A1

公开(公告)日：2005-09-15

申请号：US11076995

申请日：2005-03-11

Applicant: Matthew Olson ,  Martin Grandi ,  Amarnauth Prashad

Inventor： Matthew Olson ,  Martin Grandi ,  Amarnauth Prashad

IPC: A61K31/4166 ,  C07D233/74 ,  C07D233/76 ,  C07D471/10

CPC classification number: C07D233/76 ,  C07D471/10

Abstract: The present invention relates to hydantoin derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the hydantoin derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the hydantoin derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.

Abstract translation: 本发明涉及具有RNA酶H，聚合酶和/或HIV逆转录酶调节的乙内酰脲衍生物，特别是抑制活性。 本发明包括乙内酰脲衍生物，含有衍生物的组合物，衍生物的合成方法，鉴定衍生物的筛选方法以及使用乙内酰脲衍生物的治疗方法，包括治疗HIV，AIDS和逆转录病毒相关癌症。

公开(公告)号：US09045930B2

公开(公告)日：2015-06-02

申请号：US13090456

申请日：2011-04-20

Applicant: Matthew Olson ,  Paul Kubinski ,  Romell Alaman

Inventor： Matthew Olson ,  Paul Kubinski ,  Romell Alaman

IPC: E05F15/00

CPC classification number: E05F15/50 ,  E05F15/53 ,  E05F15/565 ,  E05Y2400/36 ,  E05Y2400/40 ,  E05Y2400/452 ,  E05Y2900/51 ,  Y10T307/76

Abstract: An electric circuit with speed control and diode separation for use with an electrically actuatable mechanism. An operator input provides a signal to a controller of the electric circuit. The controller causes a MOSFET relay to provide a voltage to the electrically actuatable mechanism. The relay is adapted to vary the voltage in response to pulse width modified signals from the controller.

Abstract translation: 具有速度控制和二极管分离的电路，可与电致动机构一起使用。 操作员输入向电路的控制器提供信号。 控制器使MOSFET继电器向电致动机构提供电压。 继电器适于响应于来自控制器的脉冲宽度修改信号来改变电压。

公开(公告)号：US20070215769A1

公开(公告)日：2007-09-20

申请号：US11376682

申请日：2006-03-15

Applicant: Michael Nebeker ,  Matthew Olson ,  Anthony Anderson ,  James Ebner

Inventor： Michael Nebeker ,  Matthew Olson ,  Anthony Anderson ,  James Ebner

IPC: A47B96/06

CPC classification number: F16B5/07 ,  B60R13/0206 ,  B60R13/0237 ,  Y10T24/45089 ,  Y10T24/45099 ,  Y10T403/60 ,  Y10T403/606

Abstract: A retaining component for securing an external structure or panel to a seat track within a mobile platform, such as an aircraft. The retaining component includes a pair of flexible flanges that are adapted to engage an external component or panel, in one example a seat track in a commercial aircraft cabin area. The retaining component also includes a base portion having a flexible portion with at least one locking tab protruding therefrom. One or more hook-shaped engaging tabs also protrude from the base portion. The engaging tabs and the locking tab enable the retaining component to be secured to a flange of a seat track having a plurality of spaced apart holes in a manner that does not require any external threaded or rivet style fastening elements, or the use of separate assembly tools. The retaining component, in one form, is a single piece, lightweight, integrally formed component that is ideally suited for use in mobile platforms such as commercial aircraft where assembly time and costs are important considerations in the manufacture of a commercial aircraft.

Abstract translation: 用于将外部结构或面板固定到诸如飞行器的移动平台内的座椅轨道的保持部件。 保持部件包括一对柔性凸缘，其适于接合外部部件或面板，在一个示例中是商用飞机机舱区域中的座椅轨道。 保持部件还包括具有柔性部分的基部部分，其中至少一个锁定突片从其突出。 一个或多个钩形接合突片也从基部突出。 接合突片和锁定突舌使得保持部件能够以不需要任何外部螺纹或铆钉式紧固元件的方式固定到具有多个间隔开的孔的座椅轨道的凸缘上，或者使用单独的组件 工具 一种形式的保持部件是单件，重量轻，整体形成的部件，其理想地适用于诸如商用飞机的移动平台，其中组装时间和成本是制造商用飞机的重要考虑因素。

公开(公告)号：US20060268280A1

公开(公告)日：2006-11-30

申请号：US11139818

申请日：2005-05-27

Applicant: Andrew Kaliszek ,  Matthew Olson ,  Clarence Laskoskie

Inventor： Andrew Kaliszek ,  Matthew Olson ,  Clarence Laskoskie

IPC: G01C19/72

CPC classification number: G01C19/722

Abstract: A sensing coil is provided for optically guiding counter-propagating light beams in a fiber optic gyroscope. The sensing coil comprises a plurality of layers of an optical fiber having a winding direction. The plurality of layers comprises inner layers, middle layers, and outer layers. The middle layers comprise first and second input ends configured to receive the counter-propagating light beams. At least one of the inner layers, middle layers, and outer layers is coupled with a different one of the inner layers, middle layers, and outer layers while maintaining the winding direction. A method is provided for winding an optical fiber, having first and second connecting ends, to form a sensing coil for a fiber optic gyroscope having a winding direction. The method comprises excluding first and second segments from a middle layer of the sensing coil to produce first and second inputs and third and fourth connecting ends respectively adjacent to the first and second inputs, and coupling each of the connecting ends with a different one of the connecting ends while maintaining the winding direction.

Abstract translation: 提供感测线圈用于在光纤陀螺仪中光学引导反向传播的光束。 感测线圈包括具有卷绕方向的多个光纤层。 多个层包括内层，中间层和外层。 中间层包括被配置为接收反向传播光束的第一和第二输入端。 内层，中层和外层中的至少一层与内层，中层和外层中的不同的一层耦合，同时保持卷绕方向。 提供一种用于卷绕具有第一和第二连接端的光纤的方法，以形成具有卷绕方向的光纤陀螺仪的感测线圈。 该方法包括从感测线圈的中间层排除第一和第二段以产生第一和第二输入以及分别与第一和第二输入相邻的第三和第四连接端，并且将每个连接端与不同的一个 同时保持卷绕方向。