公开(公告)号：US20080253515A1

公开(公告)日：2008-10-16

申请号：US11815016

申请日：2006-01-31

Applicant: Matthias Bertram ,  Jens Wiegert

Inventor： Matthias Bertram ,  Jens Wiegert

IPC: G01N23/204

CPC classification number: G01N23/04 ,  A61B6/583 ,  G06T11/005 ,  G06T2211/424

Abstract: The present invention relates to an apparatus for iterative scatter correction of a data set of x-ray projections (10) of an object (1) for generation of a reconstruction image of said object. In particular for correction of artifacts caused by scatter or a truncation of x-ray projections, an apparatus is proposed, which requires less computational effort and which thus allows a correction in real-time, comprising: a model estimation unit (41) for estimating model parameters of an object model for said object by an iterative optimization of a deviation of forward projections, calculated by use of said object model and the geometry parameters for said x-ray projections, from the corresponding x-ray projections, —a scatter estimation unit (42) for estimating the amount of scatter present in said x-ray projections by use of said object model, and a correction unit (43) for correcting said x-ray projections by subtracting the estimated amount of scatter from said x-ray projections for determining an optimized object model using said corrected x-ray projections, said optimized object model being used in another iteration of said scatter correction, said scatter correction being iteratively carried out until a predetermined stop criterion has been reached. Further, corresponding apparatus for extension of truncated projections and a reconstruction apparatus is proposed.

Abstract translation: 本发明涉及用于产生所述对象的重建图像的对象（1）的X射线投影（10）的数据集的迭代散射校正的装置。 特别是对于由X射线投影的分散或截断引起的伪像的校正，提出了一种需要较少计算量并因此允许实时校正的装置，包括：用于估计的模型估计单元（41） 通过使用所述对象模型计算的前向投影的偏差和用于所述x射线投影的几何参数从相应的x射线投影的迭代优化，对所述对象的对象模型的模型参数， - 散射估计 单元（42），用于通过使用所述对象模型来估计存在于所述x射线投影中的散射量;以及校正单元（43），用于通过从所述x射线减去估计的散射量来校正所述x射线投影 用于使用所述校正的x射线投影确定优化对象模型的投影，所述优化对象模型用于所述散射校正的另一次迭代，所述散射校正b 迭代地进行直到达到预定的停止标准。 此外，提出了用于扩展截断投影的相应装置和重建装置。

公开(公告)号：US09659365B2

公开(公告)日：2017-05-23

申请号：US13640574

申请日：2011-04-05

Applicant: Alexandra Groth ,  Qi Sun ,  Matthias Bertram

Inventor： Alexandra Groth ,  Qi Sun ,  Matthias Bertram

IPC: G06K9/00 ,  G06T7/00

CPC classification number: G06T7/0012 ,  G06T2207/10072 ,  G06T2207/10116 ,  G06T2207/20108 ,  G06T2207/30104

Abstract: A flow pattern in a tube system is calculated from acquired image data. From the flow pattern virtual image data are generated and compared with the acquired data in order to determine a quality measure for the usability of the generated flow pattern at characteristic locations.

公开(公告)号：US09014780B2

公开(公告)日：2015-04-21

申请号：US12942269

申请日：2010-11-09

Applicant: Herfried Wieczorek ,  Matthias Bertram

Inventor： Herfried Wieczorek ,  Matthias Bertram

IPC: A61B5/05 ,  A61B6/03 ,  A61B6/00 ,  A61B19/00 ,  A61B10/02 ,  G01R33/48

CPC classification number: A61B6/032 ,  A61B6/037 ,  A61B6/4233 ,  A61B6/4417 ,  A61B6/487 ,  A61B6/5235 ,  A61B6/5264 ,  A61B10/0233 ,  A61B34/10 ,  A61B2034/107 ,  A61B2034/2065 ,  A61B2090/364 ,  G01R33/481

Abstract: When performing image-guided biopsy of an anatomical structure in a patient, a target anatomical patient region containing biopsy target is imaged using both SPECT and XCT concurrently. 3D SPECT and XCT image data is fused to generate a fused 3D reference image that is overlaid on 2D patient image(s) generated during the biopsy procedure to generate an overlay image. The overlay image also includes a planned path or trajectory for a biopsy instrument. The 2D patient images are generated using SPECT and/or XCT, and are updated periodically to show biopsy instrument position and progress.

Abstract translation: 当在患者中进行解剖结构的图像引导活组织检查时，使用SPECT和XCT同时成像含有活组织检查靶的目标解剖学患者区域。 融合3D SPECT和XCT图像数据以产生融合的3D参考图像，其覆盖在活检过程中产生的2D患者图像上以产生覆盖图像。 覆盖图像还包括活检仪器的计划路径或轨迹。 使用SPECT和/或XCT生成2D患者图像，并且周期性地更新以显示活检仪器的位置和进展。

公开(公告)号：US08712121B2

公开(公告)日：2014-04-29

申请号：US13000030

申请日：2009-06-23

Applicant: Jens Wiegert ,  Matthias Bertram

Inventor： Jens Wiegert ,  Matthias Bertram

IPC: G06K9/00

CPC classification number: G06T11/005 ,  A61B6/032 ,  A61B6/542

Abstract: The present invention relates to an image generation device for generating an image from measured data, wherein image quality is optimized for a region of interest and to an imaging system comprising this image generation device. The image generation device comprises a noise determination unit for determining a distribution of noise in a projection domain of the region of interest, and a dose control unit (32) for determining a dose profile for a radiation source (2) of said image generation device based on said determined distribution of noise by using a noise propagation algorithm. Thereby, signal-to-noise ratio of a reconstructed volume can be improved and is not sensitively dependent on a selected region of interest.

Abstract translation: 本发明涉及一种用于根据测量数据产生图像的图像产生装置，其中对于感兴趣的区域和包括该图像生成装置的成像系统优化图像质量。 该图像生成装置包括用于确定感兴趣区域的投影域中的噪声分布的噪声确定单元，以及用于确定所述图像生成装置的辐射源（2）的剂量分布的剂量控制单元（32） 基于所述确定的噪声分布，使用噪声传播算法。 因此，可以改善重建体积的信噪比并且不敏感地依赖于所选择的感兴趣区域。

公开(公告)号：US20130208957A1

公开(公告)日：2013-08-15

申请号：US13700496

申请日：2011-05-19

Applicant: Steffen Gunther Wiesner ,  Matthias Bertram ,  Ming De Lin

Inventor： Steffen Gunther Wiesner ,  Matthias Bertram ,  Ming De Lin

IPC: A61B5/00

CPC classification number: A61B5/0033 ,  A61B6/507 ,  G06T7/0014 ,  G06T2207/10081 ,  G06T2207/10096 ,  G06T2207/30056 ,  G06T2207/30096

Abstract: The present invention relates to a device (2) for automatically quantifying intravascular embolization success, comprising a registration unit (4) adapted for registering a first image and a second image, a segmentation unit (6) adapted for segmenting a tissue of interest in the first image and in the second image and an evaluation unit (8) for evaluating a deviation of perfusion of the tissue of interest by comparing the first image and the second image. The first image is obtained before an interventional treatment, whereas the second image is obtained after such a treatment. Evaluating may comprise comparing the segments of the first and the second images and thus providing a quantitative measure for a perfusion deviation of the tissue, e.g. the perfusion deviation of a tumorous tissue before and after an embolization treatment.

Abstract translation: 本发明涉及一种用于自动量化血管内栓塞成功的装置（2），包括适用于登记第一图像和第二图像的注册单元（4），适于在所述第一图像和第二图像中分割感兴趣组织的分割单元（6） 第一图像和第二图像;以及评估单元（8），用于通过比较第一图像和第二图像来评估感兴趣组织的灌注偏差。 在介入治疗之前获得第一图像，而在这种治疗后获得第二图像。 评估可以包括比较第一和第二图像的片段，并且因此提供组织灌注偏差的定量测量，例如。 栓塞治疗前后肿瘤组织灌注偏差。

公开(公告)号：US08488902B2

公开(公告)日：2013-07-16

申请号：US12692786

申请日：2010-01-25

Applicant: Matthias Bertram

Inventor： Matthias Bertram

IPC: G06K9/40

CPC classification number: A61B6/032 ,  A61B6/4441 ,  A61B6/482 ,  G06T5/003 ,  G06T5/20 ,  G06T2207/10081

Abstract: The present invention relates to a detection values correction apparatus for correcting detection values of a projection image of a multi-energy imaging system. A scatter contribution providing unit provides scatter contributions for different intensities, different energies and different locations on the detection surface of the detection values. A scatter contributions combining unit combines scatter contributions for correcting a detection value, wherein the combined scatter contributions represent the contribution of the scatter, which is caused by radiation of the other detection values of the projection image, to the detection value to be corrected and wherein the scatter contributions are combined under consideration of the intensity, energy and location on the detection surface of the other detection values. A correction unit scatter corrects the detection value of the projection image by using the combined scatter contributions.

Abstract translation: 本发明涉及一种用于校正多能量成像系统的投影图像的检测值的检测值校正装置。 散射贡献提供单元为检测值的检测表面上的不同强度，不同能量和不同位置提供散射贡献。 散射贡献组合单元组合用于校正检测值的散射贡献，其中组合散射贡献表示由投影图像的其他检测值的辐射引起的散射对待校正的检测值的贡献，并且其中 在考虑其他检测值的检测表面上的强度，能量和位置的情况下组合散射贡献。 校正单位散射通过使用组合散射贡献校正投影图像的检测值。

公开(公告)号：US20110164722A1

公开(公告)日：2011-07-07

申请号：US13063486

申请日：2009-09-09

Applicant: Jens Wiegert ,  Matthias Bertram

Inventor： Jens Wiegert ,  Matthias Bertram

IPC: A61B6/03

CPC classification number: G06T11/005 ,  A61B6/027 ,  A61B6/4291

Abstract: The present invention relates to an imaging apparatus for generating an image of a region of interest of an object. The imaging apparatus comprises a radiation source (2) for emitting radiation (4) and a detector (6) for measuring the radiation (4) after having traversed the region of interest and for generating measured detection values depending on the measured radiation (4). The imaging apparatus further comprises an attenuation element for attenuating the radiation (4) before traversing the region of interest and an attenuation element scatter values providing unit (12) for providing attenuation element scatter values, which depend on scattering of the radiation (4) caused by the attenuation element. A detection values correction unit (17) corrects the measured detection values based on the provided attenuation element scatter values, and a reconstruction unit (18) reconstructs an image of the region of interest from the corrected detection values.

Abstract translation: 本发明涉及一种用于生成对象的感兴趣区域的图像的成像装置。 成像设备包括用于发射辐射的辐射源（2）和用于在穿过感兴趣区域之后测量辐射（4）的检测器（6），并且用于根据所测量的辐射（4）产生测量的检测值， 。 成像装置还包括用于在穿过感兴趣区域之前衰减辐射（4）的衰减元件和用于提供依赖于辐射（4）的散射的衰减元件散射值的衰减元件散射值提供单元（12） 通过衰减元件。 检测值校正单元（17）基于所提供的衰减元件散射值来校正测量的检测值，并且重建单元（18）从校正的检测值重建感兴趣区域的图像。

公开(公告)号：US20100208971A1

公开(公告)日：2010-08-19

申请号：US12679961

申请日：2008-09-24

Applicant: Christoph Neukirchen ,  Matthias Bertram

Inventor： Christoph Neukirchen ,  Matthias Bertram

IPC: G06K9/00

CPC classification number: A61B6/504 ,  A61B6/032 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/507

Abstract: It is provided a method for imaging a dynamic process in a part of the body, especially blood perfusion, with an x-ray system as well as corresponding apparatuses and a corresponding computer readable medium. Especially it is described a method for imaging a dynamic process in a part of the body, especially blood perfusion, with an x-ray system, comprising: acquiring rotational projections of the part of the body over an angular range (2), deriving the anatomy of the part of the body subject to the dynamic process using a tomographic reconstruction from the projections (3), determining an optimal position of the x-ray system according to the derived anatomy for acquiring projections of the dynamic process (4), administering contrast agent to the part of the body (5), acquiring projections of the dynamic process from the determined position (6); calculating the dynamic contrast enhancement over time (7); and calculating and displaying perfusion parameters (8).

Abstract translation: 提供了一种用于利用x射线系统以及对应的装置和相应的计算机可读介质对身体的一部分，特别是血液灌注中的动态过程进行成像的方法。 特别地，描述了一种利用x射线系统对身体的一部分，特别是血液灌注中的动态过程进行成像的方法，包括：在角度范围（2）上获取身体部分的旋转突起，导出 使用来自投影（3）的断层摄影重建的动态过程的身体部分的解剖结构，根据导出的解剖结构确定x射线系统的最佳位置以获取动态过程（4）的投影，管理 造影剂到身体的一部分（5），从确定的位置（6）获取动态过程的投影; 随着时间的推移计算动态对比度增强（7）; 并计算和显示灌注参数（8）。

公开(公告)号：US20090202127A1

公开(公告)日：2009-08-13

申请号：US12305983

申请日：2007-06-13

Applicant: Matthias Bertram ,  Jens Wiegert ,  Jan Timmer ,  Nicolaas Jan Noordhoek

Inventor： Matthias Bertram ,  Jens Wiegert ,  Jan Timmer ,  Nicolaas Jan Noordhoek

IPC: G06K9/00

CPC classification number: G06T11/005 ,  G06T5/003 ,  G06T2207/10081 ,  G06T2207/30004

Abstract: A method for generating a set of kernels for convolution error compensation of a projection image of a physical object recorded by an imaging system comprises calculating the set of kernels in such a way that for each pixel of the projection image an asymmetric scatter distribution for error compensation is calculated representing a X-ray scatter originating along a ray from an X-ray source to the pixel.

Abstract translation: 用于生成用于由成像系统记录的物理物体的投影图像的卷积误差补偿的一组内核的方法包括以对投影图像的每个像素进行误差补偿的不对称散布分布的方式来计算该组内核 表示沿着从X射线源到像素的射线发生的X射线散射。

公开(公告)号：US20090154787A1

公开(公告)日：2009-06-18

申请号：US11719554

申请日：2005-11-22

Applicant: Matthias Bertram ,  Til Aach ,  Georg Hans Rose ,  Dirk Schaefer

Inventor： Matthias Bertram ,  Til Aach ,  Georg Hans Rose ,  Dirk Schaefer

IPC: G06K9/00

CPC classification number: G06T11/005

Abstract: The present invention relates to an image reconstruction device and a corresponding method for reconstructing a 3D image of an object (7) from projection data of said object (7). In order to obtain 3D images having sharp high-contrast structures and almost no image blur, and in which streak artifacts (and noise in tissue-like regions) are strongly reduced, an image reconstruction device is proposed comprising: a first reconstruction unit (30) for reconstructing a first 3D image of said object (7) using the original projection data, an interpolation unit (31) for calculating interpolated projection data from said original projection data, —a second reconstruction unit (32) for reconstructing a second 3D image of said object (7) using at least the interpolated projection data, a segmentation unit (33) for segmentation of the first or second 3D image into high-contrast and low-contrast areas, a third reconstruction unit (34) for reconstructing a third 3D image from selected areas of said first and said second 3D image, wherein said segmented 3D image is used to select image values from said first 3D image for high-contrast areas and image values from said second 3D image for low-contrast areas.

Abstract translation: 本发明涉及一种从所述物体（7）的投影数据重建物体（7）的3D图像的图像重建装置和相应的方法。 为了获得具有锐利的高对比度结构并且几乎没有图像模糊的3D图像，并且其中强烈减少了条纹伪影（和组织样区域中的噪声），提出了一种图像重建装置，包括：第一重建单元（30 ），用于使用原始投影数据重建所述对象（7）的第一3D图像;内插单元（31），用于从所述原始投影数据计算内插投影数据;第二重建单元（32），用于重建第二3D图像 使用至少内插投影数据的分割单元（33），用于将第一或第二3D图像分割为高对比度和低对比度区域的分割单元（33），用于重建第三或第二3D图像的第三重建单元 所述第一和第二3D图像的所选区域的3D图像，其中所述分割的3D图像用于从所述第一3D图像中选择用于高对比度区域的图像值，并且来自所述第二3D图像的图像值 D图像用于低对比度区域。